| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 2,256,398 | 54,154,000 | 17.47% | ||
| 2 | Novo Holdings A/S | 2,175,025 | 52,201,000 | 16.84% | ||
| 3 | TPG Group Holdings (SBS) Advisors, Inc. | 2,159,335 | 51,824,000 | 16.72% | ||
| 4 | JENNISON ASSOCIATES LLC | 1,204,100 | 28,898,000 | 9.32% | ||
| 5 | PERCEPTIVE ADVISORS LLC | 837,400 | 20,098,000 | 6.48% | ||
| 6 | ALLIANCEBERNSTEIN L.P. | 667,356 | 16,017,000 | 5.17% | ||
| 7 | FEDERATED HERMES, INC. | 668,255 | 15,090,000 | 4.87% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 521,100 | 12,506,000 | 4.04% | ||
| 9 | WELLINGTON MANAGEMENT GROUP LLP | 375,095 | 9,003,000 | 2.90% | ||
| 10 | CLOUGH CAPITAL PARTNERS L P | 334,603 | 8,030,000 | 2.59% | ||
| 11 | FMR LLC | 204,013 | 4,896,000 | 1.58% | ||
| 12 | BlackRock Fund Advisors | 177,034 | 4,249,000 | 1.37% | ||
| 13 | TIVERTON ASSET MANAGEMENT LLC | 136,822 | 3,284,000 | 1.06% | ||
| 14 | GOLDMAN SACHS GROUP INC | 133,052 | 3,193,000 | 1.03% | ||
| 15 | BLACKROCK ADVISORS LLC | 112,328 | 2,695,000 | 0.87% | ||
| 16 | SPHERA FUNDS MANAGEMENT LTD. | 111,085 | 2,666,000 | 0.86% | ||
| 17 | D. E. Shaw & Co., Inc. | 103,459 | 2,483,000 | 0.80% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 64,041 | 1,537,000 | 0.50% | ||
| 19 | VANGUARD GROUP INC | 58,255 | 1,398,000 | 0.45% | ||
| 20 | STATE STREET CORP | 60,000 | 1,396,000 | 0.45% | ||
| 21 | PANAGORA ASSET MANAGEMENT INC | 55,261 | 1,326,000 | 0.43% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 55,190 | 1,324,000 | 0.43% | ||
| 23 | TURNER INVESTMENTS LLC | 55,040 | 1,321,000 | 0.43% | ||
| 24 | HIGHLAND CAPITAL MANAGEMENT LP | 36,091 | 866,000 | 0.28% | ||
| 25 | MILLENNIUM MANAGEMENT LLC | 35,123 | 843,000 | 0.27% | ||
| 26 | MARSHALL WACE, LLP | 32,500 | 780,000 | 0.25% | ||
| 27 | NORTHERN TRUST CORP | 30,668 | 736,000 | 0.24% | ||
| 28 | ROYAL BANK OF CANADA | 28,600 | 687,000 | 0.22% | ||
| 29 | Bank of New York Mellon Corp | 27,607 | 663,000 | 0.21% | ||
| 30 | BlackRock Investment Management, LLC | 26,708 | 641,000 | 0.21% | ||
| 31 | BlackRock Group LTD | 25,785 | 619,000 | 0.20% | ||
| 32 | JPMORGAN CHASE & CO | 25,000 | 600,000 | 0.19% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 22,412 | 538,000 | 0.17% | ||
| 34 | BANK OF AMERICA CORP /DE/ | 22,202 | 533,000 | 0.17% | ||
| 35 | MORGAN STANLEY | 21,400 | 513,000 | 0.17% | ||
| 36 | GILDER GAGNON HOWE & CO LLC | 19,203 | 461,000 | 0.15% | ||
| 37 | Redmile Group, LLC | 18,400 | 442,000 | 0.14% | ||
| 38 | Laurion Capital Management LP | 13,400 | 322,000 | 0.10% | ||
| 39 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 13,300 | 319,000 | 0.10% | ||
| 40 | TD ASSET MANAGEMENT INC | 10,400 | 250,000 | 0.08% | ||
| 41 | JANE STREET GROUP, LLC | 10,076 | 242,000 | 0.08% | ||
| 42 | TEACHERS ADVISORS, LLC | 6,700 | 161,000 | 0.05% | ||
| 43 | STRS OHIO | 2,500 | 60,000 | 0.02% | ||
| 44 | Nationwide Fund Advisors | 2,138 | 51,000 | 0.02% | ||
| 45 | CITIGROUP INC | 271 | 7,000 | 0.00% | ||
| 46 | UBS AG | 194 | 5,000 | 0.00% | ||
| 47 | Creative Planning | 100 | 2,000 | 0.00% | ||
| 48 | Tower Research Capital LLC (TRC) | 38 | 1,000 | 0.00% | ||
| 49 | DEUTSCHE BANK AG\ | 2 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
