| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 3,374,376 | 60,096,000 | 15.53% | ||
| 2 | JENNISON ASSOCIATES LLC | 2,483,917 | 44,239,000 | 11.44% | ||
| 3 | ORBIMED ADVISORS LLC | 2,256,398 | 40,186,000 | 10.39% | ||
| 4 | TPG Group Holdings (SBS) Advisors, Inc. | 2,159,335 | 38,458,000 | 9.94% | ||
| 5 | FEDERATED HERMES, INC. | 1,566,722 | 27,903,000 | 7.21% | ||
| 6 | STATE STREET CORP | 1,205,059 | 21,464,000 | 5.55% | ||
| 7 | Novo Holdings A/S | 875,025 | 15,584,000 | 4.03% | ||
| 8 | ALLIANCEBERNSTEIN L.P. | 617,744 | 11,002,000 | 2.84% | ||
| 9 | FMR LLC | 603,645 | 10,751,000 | 2.78% | ||
| 10 | VANGUARD GROUP INC | 528,540 | 9,413,000 | 2.43% | ||
| 11 | HIGHLAND CAPITAL MANAGEMENT LP | 493,114 | 8,783,000 | 2.27% | ||
| 12 | GOLDMAN SACHS GROUP INC | 434,901 | 7,746,000 | 2.00% | ||
| 13 | BlackRock Fund Advisors | 385,469 | 6,865,000 | 1.77% | ||
| 14 | ALPS ADVISORS INC | 37,774 | 6,728,000 | 1.74% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 374,415 | 6,668,000 | 1.72% | ||
| 16 | EverPoint Asset Management, LLC | 340,000 | 6,055,000 | 1.57% | ||
| 17 | Rock Springs Capital Management LP | 320,800 | 5,713,000 | 1.48% | ||
| 18 | Bank of New York Mellon Corp | 284,196 | 5,062,000 | 1.31% | ||
| 19 | CLOUGH CAPITAL PARTNERS L P | 269,503 | 4,800,000 | 1.24% | ||
| 20 | TIVERTON ASSET MANAGEMENT LLC | 255,713 | 4,555,000 | 1.18% | ||
| 21 | CITADEL ADVISORS LLC | 245,173 | 4,367,000 | 1.13% | ||
| 22 | BLACKROCK ADVISORS LLC | 228,080 | 4,063,000 | 1.05% | ||
| 23 | NORTHERN TRUST CORP | 200,639 | 3,573,000 | 0.92% | ||
| 24 | HARVEY CAPITAL MANAGEMENT INC | 157,925 | 2,812,000 | 0.73% | ||
| 25 | ASCEND CAPITAL, LLC | 118,600 | 2,112,000 | 0.55% | ||
| 26 | DAFNA Capital Management LLC | 111,466 | 1,985,000 | 0.51% | ||
| 27 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 110,000 | 1,959,000 | 0.51% | ||
| 28 | Advisors Asset Management, Inc. | 108,907 | 1,940,000 | 0.50% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 105,998 | 1,887,000 | 0.49% | ||
| 30 | TFS CAPITAL LLC | 86,303 | 1,537,000 | 0.40% | ||
| 31 | D. E. Shaw & Co., Inc. | 85,118 | 1,516,000 | 0.39% | ||
| 32 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 78,530 | 1,399,000 | 0.36% | ||
| 33 | Amici Capital, LLC | 75,940 | 1,352,000 | 0.35% | ||
| 34 | FIL Ltd | 66,541 | 1,185,000 | 0.31% | ||
| 35 | BlackRock Investment Management, LLC | 63,192 | 1,125,000 | 0.29% | ||
| 36 | Artisan Partners Limited Partnership | 55,879 | 995,000 | 0.26% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 49,094 | 874,000 | 0.23% | ||
| 38 | PANAGORA ASSET MANAGEMENT INC | 44,208 | 787,000 | 0.20% | ||
| 39 | MACQUARIE GROUP LTD | 44,079 | 785,000 | 0.20% | ||
| 40 | COLUMBUS CIRCLE INVESTORS | 32,055 | 571,000 | 0.15% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 26,879 | 479,000 | 0.12% | ||
| 42 | Nationwide Fund Advisors | 25,899 | 461,000 | 0.12% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 25,287 | 450,000 | 0.12% | ||
| 44 | MILLENNIUM MANAGEMENT LLC | 24,236 | 432,000 | 0.11% | ||
| 45 | MORGAN STANLEY | 24,005 | 428,000 | 0.11% | ||
| 46 | FRED ALGER MANAGEMENT, LLC | 23,600 | 420,000 | 0.11% | ||
| 47 | TEACHERS ADVISORS, LLC | 21,599 | 385,000 | 0.10% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 21,039 | 375,000 | 0.10% | ||
| 49 | PERCEPTIVE ADVISORS LLC | 185,368 | 364,000 | 0.09% | ||
| 50 | AMERICAN INTERNATIONAL GROUP, INC. | 19,907 | 354,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
