| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JENNISON ASSOCIATES LLC | 2,287,877 | 80,899,000 | 12.08% | ||
| 2 | ORBIMED ADVISORS LLC | 2,256,398 | 79,786,000 | 11.91% | ||
| 3 | Novo Holdings A/S | 2,175,025 | 76,909,000 | 11.48% | ||
| 4 | TPG Group Holdings (SBS) Advisors, Inc. | 2,159,335 | 76,354,000 | 11.40% | ||
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 1,841,116 | 65,102,000 | 9.72% | ||
| 6 | FEDERATED HERMES, INC. | 1,616,082 | 57,145,000 | 8.53% | ||
| 7 | FMR LLC | 916,338 | 32,402,000 | 4.84% | ||
| 8 | STATE STREET CORP | 660,096 | 23,340,000 | 3.49% | ||
| 9 | HIGHLAND CAPITAL MANAGEMENT LP | 642,341 | 22,713,000 | 3.39% | ||
| 10 | ALLIANCEBERNSTEIN L.P. | 509,052 | 18,000,000 | 2.69% | ||
| 11 | PERCEPTIVE ADVISORS LLC | 480,387 | 16,986,000 | 2.54% | ||
| 12 | GOLDMAN SACHS GROUP INC | 422,645 | 14,945,000 | 2.23% | ||
| 13 | VANGUARD GROUP INC | 422,297 | 14,932,000 | 2.23% | ||
| 14 | CLOUGH CAPITAL PARTNERS L P | 251,605 | 8,897,000 | 1.33% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 225,758 | 7,983,000 | 1.19% | ||
| 16 | BlackRock Fund Advisors | 224,841 | 7,950,000 | 1.19% | ||
| 17 | TIVERTON ASSET MANAGEMENT LLC | 211,822 | 7,490,000 | 1.12% | ||
| 18 | MILLENNIUM MANAGEMENT LLC | 199,460 | 7,053,000 | 1.05% | ||
| 19 | D. E. Shaw & Co., Inc. | 158,877 | 5,618,000 | 0.84% | ||
| 20 | PRICE T ROWE ASSOCIATES INC /MD/ | 131,638 | 4,655,000 | 0.70% | ||
| 21 | NORTHERN TRUST CORP | 118,028 | 4,173,000 | 0.62% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 93,659 | 3,311,000 | 0.49% | ||
| 23 | Redmile Group, LLC | 78,972 | 2,792,000 | 0.42% | ||
| 24 | SPHERA FUNDS MANAGEMENT LTD. | 70,000 | 2,475,000 | 0.37% | ||
| 25 | Spark Investment Management LLC | 63,900 | 2,258,000 | 0.34% | ||
| 26 | Artisan Partners Limited Partnership | 55,879 | 1,976,000 | 0.30% | ||
| 27 | FIL Ltd | 52,018 | 1,839,000 | 0.27% | ||
| 28 | DAFNA Capital Management LLC | 50,000 | 1,768,000 | 0.26% | ||
| 29 | Bank of New York Mellon Corp | 49,827 | 1,762,000 | 0.26% | ||
| 30 | PICTON MAHONEY ASSET MANAGEMENT | 43,689 | 1,545,000 | 0.23% | SH | |
| 31 | Advisors Asset Management, Inc. | 34,737 | 1,228,000 | 0.18% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 33,890 | 1,198,000 | 0.18% | ||
| 33 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 33,150 | 1,172,000 | 0.18% | ||
| 34 | MACQUARIE GROUP LTD | 30,495 | 1,078,000 | 0.16% | ||
| 35 | RUSSELL FRANK CO/ | 27,541 | 974,000 | 0.15% | ||
| 36 | BlackRock Investment Management, LLC | 23,717 | 839,000 | 0.13% | ||
| 37 | FRED ALGER MANAGEMENT, LLC | 23,600 | 834,000 | 0.12% | ||
| 38 | Sterling Capital Management LLC | 23,144 | 818,000 | 0.12% | ||
| 39 | PANAGORA ASSET MANAGEMENT INC | 20,322 | 719,000 | 0.11% | ||
| 40 | ACUTA CAPITAL PARTNERS, LLC | 20,000 | 707,000 | 0.11% | ||
| 41 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 20,000 | 707,000 | 0.11% | ||
| 42 | Nationwide Fund Advisors | 19,472 | 689,000 | 0.10% | ||
| 43 | TFS CAPITAL LLC | 18,554 | 656,000 | 0.10% | ||
| 44 | MORGAN STANLEY | 17,942 | 634,000 | 0.09% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,657 | 518,000 | 0.08% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 12,739 | 450,000 | 0.07% | ||
| 47 | Swiss National Bank | 12,100 | 428,000 | 0.06% | ||
| 48 | Opus Point Partners Management, LLC | 12,000 | 424,000 | 0.06% | ||
| 49 | TEACHERS ADVISORS, LLC | 11,635 | 411,000 | 0.06% | ||
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10,500 | 372,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
