| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 3,334,249 | 76,655,000 | 16.11% | ||
| 2 | JENNISON ASSOCIATES LLC | 2,342,861 | 53,862,000 | 11.32% | ||
| 3 | ORBIMED ADVISORS LLC | 2,256,398 | 51,875,000 | 10.90% | ||
| 4 | TPG Group Holdings (SBS) Advisors, Inc. | 2,159,335 | 49,643,000 | 10.44% | ||
| 5 | FEDERATED HERMES, INC. | 1,513,601 | 34,798,000 | 7.31% | ||
| 6 | STATE STREET CORP | 1,244,916 | 28,620,000 | 6.02% | ||
| 7 | Novo Holdings A/S | 875,025 | 20,117,000 | 4.23% | ||
| 8 | FMR LLC | 701,117 | 16,119,000 | 3.39% | ||
| 9 | HIGHLAND CAPITAL MANAGEMENT LP | 665,007 | 15,288,000 | 3.21% | ||
| 10 | ALLIANCEBERNSTEIN L.P. | 551,416 | 12,677,000 | 2.66% | ||
| 11 | GOLDMAN SACHS GROUP INC | 496,672 | 11,418,000 | 2.40% | ||
| 12 | VANGUARD GROUP INC | 479,042 | 11,014,000 | 2.32% | ||
| 13 | BlackRock Fund Advisors | 389,944 | 8,965,000 | 1.88% | ||
| 14 | PERCEPTIVE ADVISORS LLC | 367,386 | 8,446,000 | 1.78% | ||
| 15 | Rock Springs Capital Management LP | 320,800 | 7,375,000 | 1.55% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 286,573 | 6,588,000 | 1.38% | ||
| 17 | TIVERTON ASSET MANAGEMENT LLC | 255,713 | 5,879,000 | 1.24% | ||
| 18 | CITADEL ADVISORS LLC | 228,505 | 5,253,000 | 1.10% | ||
| 19 | CLOUGH CAPITAL PARTNERS L P | 165,903 | 3,814,000 | 0.80% | ||
| 20 | D. E. Shaw & Co., Inc. | 130,963 | 3,011,000 | 0.63% | ||
| 21 | HARVEY CAPITAL MANAGEMENT INC | 120,375 | 2,659,000 | 0.56% | ||
| 22 | SPHERA FUNDS MANAGEMENT LTD. | 113,000 | 2,598,000 | 0.55% | ||
| 23 | DAFNA Capital Management LLC | 111,466 | 2,563,000 | 0.54% | ||
| 24 | NORTHERN TRUST CORP | 111,294 | 2,558,000 | 0.54% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 103,139 | 2,371,000 | 0.50% | ||
| 26 | Bank of New York Mellon Corp | 79,470 | 1,827,000 | 0.38% | ||
| 27 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 78,530 | 1,805,000 | 0.38% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 70,694 | 1,625,000 | 0.34% | ||
| 29 | Advisors Asset Management, Inc. | 67,527 | 1,552,000 | 0.33% | ||
| 30 | FIL Ltd | 66,541 | 1,530,000 | 0.32% | ||
| 31 | RENAISSANCE TECHNOLOGIES LLC | 63,046 | 1,449,000 | 0.30% | ||
| 32 | MARSHALL WACE, LLP | 60,930 | 1,401,000 | 0.29% | ||
| 33 | DEUTSCHE BANK AG\ | 56,518 | 1,298,000 | 0.27% | ||
| 34 | Artisan Partners Limited Partnership | 55,879 | 1,285,000 | 0.27% | ||
| 35 | ACUTA CAPITAL PARTNERS, LLC | 53,400 | 1,228,000 | 0.26% | ||
| 36 | BlackRock Investment Management, LLC | 52,108 | 1,198,000 | 0.25% | ||
| 37 | CREDIT SUISSE AG/ | 51,987 | 1,195,000 | 0.25% | ||
| 38 | MACQUARIE GROUP LTD | 43,079 | 990,000 | 0.21% | ||
| 39 | Amici Capital, LLC | 32,000 | 736,000 | 0.15% | ||
| 40 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 27,106 | 623,000 | 0.13% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 26,979 | 620,000 | 0.13% | ||
| 42 | PDT Partners, LLC | 26,038 | 599,000 | 0.13% | ||
| 43 | JPMORGAN CHASE & CO | 25,677 | 590,000 | 0.12% | ||
| 44 | ALPS ADVISORS INC | 23,919 | 550,000 | 0.12% | ||
| 45 | BANK OF AMERICA CORP /DE/ | 23,625 | 543,000 | 0.11% | ||
| 46 | FRED ALGER MANAGEMENT, LLC | 23,600 | 543,000 | 0.11% | ||
| 47 | Nationwide Fund Advisors | 22,147 | 509,000 | 0.11% | ||
| 48 | Virtu KCG Holdings LLC | 21,830 | 502,000 | 0.11% | ||
| 49 | TEACHERS ADVISORS, LLC | 21,599 | 497,000 | 0.10% | ||
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 21,039 | 484,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
