| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 2,256,398 | 75,206,000 | 16.22% | ||
| 2 | Novo Holdings A/S | 2,175,025 | 72,494,000 | 15.64% | ||
| 3 | TPG Group Holdings (SBS) Advisors, Inc. | 2,159,335 | 71,971,000 | 15.53% | ||
| 4 | JENNISON ASSOCIATES LLC | 1,243,282 | 41,439,000 | 8.94% | ||
| 5 | FMR LLC | 854,338 | 28,475,000 | 6.14% | ||
| 6 | FEDERATED HERMES, INC. | 829,225 | 26,244,000 | 5.66% | ||
| 7 | ALLIANCEBERNSTEIN L.P. | 550,775 | 18,357,000 | 3.96% | ||
| 8 | PERCEPTIVE ADVISORS LLC | 454,306 | 15,142,000 | 3.27% | ||
| 9 | WELLINGTON MANAGEMENT GROUP LLP | 438,531 | 14,616,000 | 3.15% | ||
| 10 | GOLDMAN SACHS GROUP INC | 348,874 | 11,628,000 | 2.51% | ||
| 11 | CLOUGH CAPITAL PARTNERS L P | 334,705 | 11,156,000 | 2.41% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 320,915 | 10,696,000 | 2.31% | ||
| 13 | PRICE T ROWE ASSOCIATES INC /MD/ | 275,412 | 9,179,000 | 1.98% | ||
| 14 | VANGUARD GROUP INC | 243,540 | 8,118,000 | 1.75% | ||
| 15 | BlackRock Fund Advisors | 200,528 | 6,684,000 | 1.44% | ||
| 16 | TIVERTON ASSET MANAGEMENT LLC | 136,822 | 4,560,000 | 0.98% | ||
| 17 | BLACKROCK ADVISORS LLC | 127,572 | 4,252,000 | 0.92% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 125,531 | 4,184,000 | 0.90% | ||
| 19 | D. E. Shaw & Co., Inc. | 113,350 | 3,778,000 | 0.82% | ||
| 20 | JPMORGAN CHASE & CO | 88,314 | 2,944,000 | 0.64% | ||
| 21 | NORTHERN TRUST CORP | 86,677 | 2,889,000 | 0.62% | ||
| 22 | STATE STREET CORP | 85,508 | 2,850,000 | 0.61% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 82,138 | 2,737,000 | 0.59% | ||
| 24 | PANAGORA ASSET MANAGEMENT INC | 63,641 | 2,121,000 | 0.46% | ||
| 25 | Bank of New York Mellon Corp | 41,589 | 1,386,000 | 0.30% | ||
| 26 | HIGHLAND CAPITAL MANAGEMENT LP | 35,491 | 1,183,000 | 0.26% | ||
| 27 | RUSSELL FRANK CO/ | 33,043 | 1,100,000 | 0.24% | ||
| 28 | Informed Momentum Co LLC | 30,667 | 1,022,000 | 0.22% | ||
| 29 | BlackRock Investment Management, LLC | 27,362 | 912,000 | 0.20% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 24,711 | 824,000 | 0.18% | ||
| 31 | CITIGROUP INC | 19,615 | 654,000 | 0.14% | ||
| 32 | A.R.T. Advisors, LLC | 18,713 | 623,000 | 0.13% | ||
| 33 | Spark Investment Management LLC | 18,000 | 599,000 | 0.13% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 13,357 | 445,000 | 0.10% | ||
| 35 | ROYAL BANK OF CANADA | 13,331 | 445,000 | 0.10% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10,500 | 350,000 | 0.08% | ||
| 37 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 10,220 | 341,000 | 0.07% | ||
| 38 | TEACHERS ADVISORS, LLC | 9,747 | 325,000 | 0.07% | ||
| 39 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 8,157 | 272,000 | 0.06% | ||
| 40 | METROPOLITAN LIFE INSURANCE CO/NY | 6,060 | 202,000 | 0.04% | ||
| 41 | Nationwide Fund Advisors | 5,584 | 186,000 | 0.04% | ||
| 42 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 5,310 | 177,000 | 0.04% | ||
| 43 | Swiss National Bank | 5,200 | 173,000 | 0.04% | ||
| 44 | BANK OF AMERICA CORP /DE/ | 4,564 | 152,000 | 0.03% | ||
| 45 | AMERICAN INTERNATIONAL GROUP, INC. | 4,520 | 150,652 | 0.03% | ||
| 46 | BlackRock Group LTD | 2,749 | 92,000 | 0.02% | ||
| 47 | STRS OHIO | 2,500 | 83,000 | 0.02% | ||
| 48 | MORGAN STANLEY | 1,327 | 44,000 | 0.01% | ||
| 49 | UBS Group AG | 792 | 26,000 | 0.01% | ||
| 50 | Creative Planning | 400 | 13,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
