| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | GREAT POINT PARTNERS LLC | 2,111,590 | 7,876,000 | 17.52% | ||
| 2 | SABBY MANAGEMENT, LLC | 922,562 | 3,441,000 | 7.65% | ||
| 3 | BVF INC/IL | 862,069 | 3,216,000 | 7.15% | ||
| 4 | BlackRock Institutional Trust Company, N.A. | 683,312 | 2,549,000 | 5.67% | ||
| 5 | Abingworth LLP | 603,740 | 2,234,000 | 4.97% | ||
| 6 | Visium Asset Management, LP | 598,443 | 2,232,000 | 4.96% | ||
| 7 | First Eagle Investment Management, LLC | 574,712 | 2,144,000 | 4.77% | ||
| 8 | Allianz Asset Management GmbH | 522,836 | 1,950,000 | 4.34% | ||
| 9 | FMR LLC | 424,213 | 1,582,000 | 3.52% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 363,947 | 1,358,000 | 3.02% | ||
| 11 | TFS CAPITAL LLC | 360,260 | 1,344,000 | 2.99% | ||
| 12 | VANGUARD GROUP INC | 340,393 | 1,270,000 | 2.82% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 300,000 | 1,119,000 | 2.49% | Put | |
| 14 | RENAISSANCE TECHNOLOGIES LLC | 279,922 | 1,044,000 | 2.32% | ||
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 247,400 | 923,000 | 2.05% | Put | |
| 16 | BLACKROCK ADVISORS LLC | 209,100 | 780,000 | 1.73% | ||
| 17 | MORGAN STANLEY | 185,116 | 690,000 | 1.53% | ||
| 18 | DEUTSCHE BANK AG\ | 184,550 | 688,000 | 1.53% | ||
| 19 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 175,980 | 656,000 | 1.46% | ||
| 20 | NORTHERN TRUST CORP | 167,988 | 627,000 | 1.39% | ||
| 21 | TEACHERS ADVISORS, LLC | 165,887 | 619,000 | 1.38% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 165,645 | 618,000 | 1.37% | ||
| 23 | BlackRock Group LTD | 113,556 | 424,000 | 0.94% | ||
| 24 | Tekla Capital Management LLC | 113,100 | 422,000 | 0.94% | ||
| 25 | A.R.T. Advisors, LLC | 101,905 | 380,000 | 0.85% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 96,200 | 359,000 | 0.80% | Call | |
| 27 | WASATCH ADVISORS LP | 92,908 | 347,000 | 0.77% | ||
| 28 | BANK OF AMERICA CORP /DE/ | 69,884 | 260,000 | 0.58% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 65,332 | 243,000 | 0.54% | ||
| 30 | Paloma Partners Management Co | 62,851 | 234,000 | 0.52% | ||
| 31 | GROUP ONE TRADING LLC | 59,212 | 221,000 | 0.49% | ||
| 32 | PUTNAM INVESTMENTS LLC | 50,200 | 187,000 | 0.42% | ||
| 33 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 48,944 | 183,000 | 0.41% | ||
| 34 | D. E. Shaw & Co., Inc. | 48,251 | 180,000 | 0.40% | ||
| 35 | BlackRock Fund Advisors | 48,063 | 179,000 | 0.40% | ||
| 36 | COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 41,988 | 157,000 | 0.35% | ||
| 37 | CREDIT SUISSE AG/ | 40,142 | 150,000 | 0.33% | ||
| 38 | DIMENSIONAL FUND ADVISORS LP | 38,114 | 142,000 | 0.32% | ||
| 39 | BARCLAYS PLC | 41,654 | 125,000 | 0.28% | ||
| 40 | LMR Partners LLP | 31,754 | 119,000 | 0.26% | ||
| 41 | SOROS FUND MANAGEMENT LLC | 30,800 | 115,000 | 0.26% | ||
| 42 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 30,000 | 112,000 | 0.25% | ||
| 43 | GOLDMAN SACHS GROUP INC | 27,700 | 103,000 | 0.23% | Call | |
| 44 | Virtu KCG Holdings LLC | 22,747 | 84,000 | 0.19% | ||
| 45 | Spark Investment Management LLC | 22,300 | 82,000 | 0.18% | ||
| 46 | KEYBANK NATIONAL ASSOCIATION/OH | 21,624 | 81,000 | 0.18% | ||
| 47 | TWO SIGMA INVESTMENTS, LP | 19,869 | 74,000 | 0.16% | ||
| 48 | STONERIDGE INVESTMENT PARTNERS LLC | 19,163 | 71,000 | 0.16% | ||
| 49 | UBS AG | 19,100 | 71,000 | 0.16% | Put | |
| 50 | UBS AG | 19,087 | 71,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
