| 1 |
BVF INC/IL |
1,368,500 |
2,942,000 |
15.93% |
|
|
| 2 |
Allianz Asset Management GmbH |
1,045,672 |
2,248,000 |
12.17% |
|
|
| 3 |
BlackRock Institutional Trust Company, N.A. |
882,319 |
1,897,000 |
10.27% |
|
|
| 4 |
RENAISSANCE TECHNOLOGIES LLC |
630,391 |
1,355,000 |
7.33% |
|
|
| 5 |
TANG CAPITAL MANAGEMENT LLC |
628,400 |
1,351,000 |
7.31% |
|
|
| 6 |
Abingworth LLP |
603,740 |
1,274,000 |
6.90% |
|
|
| 7 |
FMR LLC |
492,454 |
1,059,000 |
5.73% |
|
|
| 8 |
VANGUARD GROUP INC |
465,498 |
1,001,000 |
5.42% |
|
|
| 9 |
Connor, Clark & Lunn Investment Management Ltd. |
391,322 |
841,000 |
4.55% |
|
|
| 10 |
BlackRock Group LTD |
219,333 |
472,000 |
2.55% |
|
|
| 11 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
215,500 |
463,000 |
2.51% |
|
|
| 12 |
BLACKROCK ADVISORS LLC |
203,017 |
436,000 |
2.36% |
|
|
| 13 |
Cheyne Capital Management (UK) LLP |
150,000 |
321,000 |
1.74% |
|
|
| 14 |
Tekla Capital Management LLC |
113,100 |
243,000 |
1.32% |
|
|
| 15 |
Nine Chapters Capital Management LLC |
96,400 |
207,000 |
1.12% |
|
|
| 16 |
BOGLE INVESTMENT MANAGEMENT L P /DE/ |
87,388 |
187,000 |
1.01% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
64,698 |
139,000 |
0.75% |
|
|
| 18 |
Virtu KCG Holdings LLC |
56,485 |
121,000 |
0.65% |
|
|
| 19 |
BlackRock Fund Advisors |
55,385 |
119,000 |
0.64% |
|
|
| 20 |
STONERIDGE INVESTMENT PARTNERS LLC |
51,512 |
111,000 |
0.60% |
|
|
| 21 |
Telemetry Investments, L.L.C. |
50,000 |
108,000 |
0.58% |
|
|
| 22 |
PUTNAM INVESTMENTS LLC |
50,200 |
108,000 |
0.58% |
|
|
| 23 |
D. E. Shaw & Co., Inc. |
47,860 |
103,000 |
0.56% |
|
|
| 24 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
48,944 |
102,000 |
0.55% |
|
|
| 25 |
NORTHERN TRUST CORP |
47,020 |
101,000 |
0.55% |
|
|
| 26 |
MORGAN STANLEY |
44,713 |
95,000 |
0.51% |
|
|
| 27 |
TWO SIGMA ADVISERS, LP |
41,484 |
89,000 |
0.48% |
|
|
| 28 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
38,200 |
82,000 |
0.44% |
|
|
| 29 |
DIMENSIONAL FUND ADVISORS LP |
37,214 |
80,000 |
0.43% |
|
|
| 30 |
CITADEL ADVISORS LLC |
35,064 |
75,000 |
0.41% |
|
|
| 31 |
PRICE T ROWE ASSOCIATES INC /MD/ |
32,500 |
70,000 |
0.38% |
|
|
| 32 |
GOLDMAN SACHS GROUP INC |
30,900 |
66,000 |
0.36% |
|
|
| 33 |
ROYAL BANK OF CANADA |
29,840 |
64,000 |
0.35% |
|
|
| 34 |
ClariVest Asset Management LLC |
27,686 |
59,000 |
0.32% |
|
|
| 35 |
THOMPSON DAVIS & CO., INC. |
26,488 |
57,000 |
0.31% |
|
|
| 36 |
NEW YORK STATE COMMON RETIREMENT FUND |
23,957 |
52,000 |
0.28% |
|
|
| 37 |
TWO SIGMA INVESTMENTS, LP |
24,000 |
52,000 |
0.28% |
|
|
| 38 |
Numeric Investors LLC |
22,600 |
49,000 |
0.27% |
|
|
| 39 |
BANK OF AMERICA CORP /DE/ |
21,465 |
46,000 |
0.25% |
|
|
| 40 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
17,600 |
38,000 |
0.21% |
Call |
|
| 41 |
Bank of New York Mellon Corp |
17,133 |
37,000 |
0.20% |
|
|
| 42 |
STATE STREET CORP |
13,029 |
27,000 |
0.15% |
|
|
| 43 |
STIFEL FINANCIAL CORP |
10,955 |
24,000 |
0.13% |
|
|
| 44 |
CITIGROUP INC |
10,376 |
22,000 |
0.12% |
|
|
| 45 |
Timber Hill LLC |
10,236 |
22,000 |
0.12% |
|
|
| 46 |
BlackRock Japan Co. Ltd |
9,869 |
21,000 |
0.11% |
|
|
| 47 |
ACADIAN ASSET MANAGEMENT LLC |
5,998 |
13,000 |
0.07% |
|
|
| 48 |
B. Riley Wealth Management, Inc. |
5,000 |
10,000 |
0.05% |
|
|
| 49 |
BlackRock Investment Management, LLC |
3,353 |
7,000 |
0.04% |
|
|
| 50 |
DEUTSCHE BANK AG\ |
2,167 |
4,000 |
0.02% |
|
|
