| 1 |
BVF INC/IL |
1,020,108 |
2,377,000 |
13.02% |
|
|
| 2 |
BlackRock Institutional Trust Company, N.A. |
952,292 |
2,219,000 |
12.15% |
|
|
| 3 |
RENAISSANCE TECHNOLOGIES LLC |
837,023 |
1,950,000 |
10.68% |
|
|
| 4 |
Allianz Asset Management GmbH |
692,836 |
1,614,000 |
8.84% |
|
|
| 5 |
Abingworth LLP |
603,740 |
1,407,000 |
7.71% |
|
|
| 6 |
VANGUARD GROUP INC |
493,469 |
1,149,000 |
6.29% |
|
|
| 7 |
Connor, Clark & Lunn Investment Management Ltd. |
418,322 |
975,000 |
5.34% |
|
|
| 8 |
FMR LLC |
405,302 |
944,000 |
5.17% |
|
|
| 9 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
215,500 |
502,000 |
2.75% |
|
|
| 10 |
BlackRock Group LTD |
202,466 |
472,000 |
2.58% |
|
|
| 11 |
TFS CAPITAL LLC |
197,961 |
461,000 |
2.52% |
|
|
| 12 |
BLACKROCK ADVISORS LLC |
196,952 |
459,000 |
2.51% |
|
|
| 13 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
152,023 |
354,000 |
1.94% |
|
|
| 14 |
Cheyne Capital Management (UK) LLP |
125,892 |
295,000 |
1.62% |
|
|
| 15 |
DEUTSCHE BANK AG\ |
114,434 |
266,000 |
1.46% |
|
|
| 16 |
Tekla Capital Management LLC |
113,100 |
264,000 |
1.45% |
|
|
| 17 |
Virtu KCG Holdings LLC |
104,608 |
244,000 |
1.34% |
|
|
| 18 |
GEODE CAPITAL MANAGEMENT, LLC |
101,522 |
236,000 |
1.29% |
|
|
| 19 |
Nine Chapters Capital Management LLC |
70,900 |
165,000 |
0.90% |
|
|
| 20 |
STONERIDGE INVESTMENT PARTNERS LLC |
70,702 |
165,000 |
0.90% |
|
|
| 21 |
BlackRock Fund Advisors |
62,975 |
147,000 |
0.81% |
|
|
| 22 |
PUTNAM INVESTMENTS LLC |
50,200 |
117,000 |
0.64% |
|
|
| 23 |
Telemetry Investments, L.L.C. |
50,000 |
116,000 |
0.64% |
|
|
| 24 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
48,944 |
114,000 |
0.62% |
|
|
| 25 |
DIMENSIONAL FUND ADVISORS LP |
41,716 |
97,000 |
0.53% |
|
|
| 26 |
NORTHERN TRUST CORP |
41,292 |
96,000 |
0.53% |
|
|
| 27 |
MORGAN STANLEY |
39,177 |
91,000 |
0.50% |
|
|
| 28 |
D. E. Shaw & Co., Inc. |
36,374 |
85,000 |
0.47% |
|
|
| 29 |
PRICE T ROWE ASSOCIATES INC /MD/ |
36,100 |
84,000 |
0.46% |
|
|
| 30 |
MILLENNIUM MANAGEMENT LLC |
34,629 |
81,000 |
0.44% |
|
|
| 31 |
GOLDMAN SACHS GROUP INC |
34,116 |
79,000 |
0.43% |
|
|
| 32 |
ROYAL BANK OF CANADA |
29,740 |
69,000 |
0.38% |
|
|
| 33 |
ClariVest Asset Management LLC |
27,686 |
64,000 |
0.35% |
|
|
| 34 |
TWO SIGMA ADVISERS, LP |
25,184 |
59,000 |
0.32% |
|
|
| 35 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
25,000 |
58,000 |
0.32% |
Call |
|
| 36 |
NEW YORK STATE COMMON RETIREMENT FUND |
23,957 |
56,000 |
0.31% |
|
|
| 37 |
BANK OF AMERICA CORP /DE/ |
21,449 |
50,000 |
0.27% |
|
|
| 38 |
Bank of New York Mellon Corp |
18,846 |
44,000 |
0.24% |
|
|
| 39 |
OPPENHEIMER & CO INC |
15,000 |
35,000 |
0.19% |
|
|
| 40 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
13,873 |
32,000 |
0.18% |
|
|
| 41 |
Rotella Capital Management, Inc. |
11,673 |
27,000 |
0.15% |
|
|
| 42 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
10,700 |
25,000 |
0.14% |
Put |
|
| 43 |
CITIGROUP INC |
10,424 |
24,000 |
0.13% |
|
|
| 44 |
STATE STREET CORP |
10,229 |
24,000 |
0.13% |
|
|
| 45 |
Timber Hill LLC |
10,036 |
23,000 |
0.13% |
|
|
| 46 |
BlackRock Japan Co. Ltd |
5,267 |
12,000 |
0.07% |
|
|
| 47 |
TCI Wealth Advisors, Inc. |
4,000 |
9,000 |
0.05% |
|
|
| 48 |
BlackRock Investment Management, LLC |
3,936 |
9,000 |
0.05% |
|
|
| 49 |
UBS Group AG |
1,301 |
3,000 |
0.02% |
|
|
| 50 |
BANK OF MONTREAL /CAN/ |
1,500 |
3,000 |
0.02% |
|
|
