| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | GREAT POINT PARTNERS LLC | 1,793,942 | 4,790,000 | 17.98% | ||
| 2 | BlackRock Institutional Trust Company, N.A. | 812,625 | 2,170,000 | 8.14% | ||
| 3 | SABBY MANAGEMENT, LLC | 787,088 | 2,102,000 | 7.89% | ||
| 4 | BVF INC/IL | 662,069 | 1,768,000 | 6.64% | ||
| 5 | Abingworth LLP | 603,740 | 1,600,000 | 6.00% | ||
| 6 | Visium Asset Management, LP | 598,443 | 1,598,000 | 6.00% | ||
| 7 | Allianz Asset Management GmbH | 522,836 | 1,396,000 | 5.24% | ||
| 8 | First Eagle Investment Management, LLC | 515,512 | 1,376,000 | 5.16% | ||
| 9 | FMR LLC | 435,441 | 1,163,000 | 4.36% | ||
| 10 | VANGUARD GROUP INC | 404,585 | 1,080,000 | 4.05% | ||
| 11 | BlackRock Group LTD | 349,180 | 932,000 | 3.50% | ||
| 12 | RENAISSANCE TECHNOLOGIES LLC | 236,415 | 631,000 | 2.37% | ||
| 13 | BLACKROCK ADVISORS LLC | 203,017 | 542,000 | 2.03% | ||
| 14 | TEACHERS ADVISORS, LLC | 165,767 | 443,000 | 1.66% | ||
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 132,300 | 353,000 | 1.32% | Put | |
| 16 | TFS CAPITAL LLC | 127,615 | 341,000 | 1.28% | ||
| 17 | GOLDMAN SACHS GROUP INC | 119,601 | 319,000 | 1.20% | ||
| 18 | JACOBS LEVY EQUITY MANAGEMENT, INC | 116,124 | 310,000 | 1.16% | ||
| 19 | Tekla Capital Management LLC | 113,100 | 302,000 | 1.13% | ||
| 20 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 100,370 | 267,000 | 1.00% | ||
| 21 | MORGAN STANLEY | 98,044 | 262,000 | 0.98% | ||
| 22 | WASATCH ADVISORS LP | 89,815 | 240,000 | 0.90% | ||
| 23 | Connor, Clark & Lunn Investment Management Ltd. | 83,000 | 222,000 | 0.83% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 74,037 | 198,000 | 0.74% | ||
| 25 | D. E. Shaw & Co., Inc. | 70,371 | 188,000 | 0.71% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 64,584 | 172,000 | 0.65% | ||
| 27 | RUSSELL FRANK CO/ | 56,784 | 152,000 | 0.57% | ||
| 28 | BlackRock Fund Advisors | 54,915 | 147,000 | 0.55% | ||
| 29 | A.R.T. Advisors, LLC | 50,845 | 135,000 | 0.51% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 50,400 | 135,000 | 0.51% | Call | |
| 31 | PUTNAM INVESTMENTS LLC | 50,200 | 134,000 | 0.50% | ||
| 32 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 48,944 | 131,000 | 0.49% | ||
| 33 | NORTHERN TRUST CORP | 47,691 | 128,000 | 0.48% | ||
| 34 | STONERIDGE INVESTMENT PARTNERS LLC | 39,710 | 106,000 | 0.40% | ||
| 35 | DIMENSIONAL FUND ADVISORS LP | 37,214 | 99,000 | 0.37% | ||
| 36 | MILLENNIUM MANAGEMENT LLC | 34,717 | 93,000 | 0.35% | ||
| 37 | CREDIT SUISSE AG/ | 31,032 | 83,000 | 0.31% | ||
| 38 | BANK OF AMERICA CORP /DE/ | 21,449 | 57,000 | 0.21% | ||
| 39 | KEYBANK NATIONAL ASSOCIATION/OH | 18,531 | 49,000 | 0.18% | ||
| 40 | PRICE T ROWE ASSOCIATES INC /MD/ | 17,500 | 47,000 | 0.18% | ||
| 41 | Bank of New York Mellon Corp | 17,132 | 46,000 | 0.17% | ||
| 42 | STIFEL FINANCIAL CORP | 14,455 | 39,000 | 0.15% | ||
| 43 | STATE STREET CORP | 14,129 | 37,000 | 0.14% | ||
| 44 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 13,600 | 36,000 | 0.14% | ||
| 45 | Virtu KCG Holdings LLC | 12,634 | 33,000 | 0.12% | ||
| 46 | GROUP ONE TRADING LLC | 12,412 | 33,000 | 0.12% | ||
| 47 | CITIGROUP INC | 11,370 | 31,000 | 0.12% | ||
| 48 | BlackRock Japan Co. Ltd | 10,754 | 29,000 | 0.11% | ||
| 49 | Timber Hill LLC | 10,236 | 27,000 | 0.10% | ||
| 50 | ROYAL BANK OF CANADA | 7,448 | 21,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
