| 1 |
BVF INC/IL |
1,368,500 |
3,134,000 |
14.53% |
|
|
| 2 |
Allianz Asset Management GmbH |
1,045,672 |
2,394,000 |
11.10% |
|
|
| 3 |
BlackRock Institutional Trust Company, N.A. |
839,589 |
1,923,000 |
8.91% |
|
|
| 4 |
Abingworth LLP |
603,740 |
1,352,000 |
6.27% |
|
|
| 5 |
FMR LLC |
577,934 |
1,323,000 |
6.13% |
|
|
| 6 |
First Eagle Investment Management, LLC |
515,512 |
1,181,000 |
5.47% |
|
|
| 7 |
SABBY MANAGEMENT, LLC |
461,957 |
1,058,000 |
4.90% |
|
|
| 8 |
VANGUARD GROUP INC |
419,357 |
960,000 |
4.45% |
|
|
| 9 |
BlackRock Group LTD |
413,606 |
947,000 |
4.39% |
|
|
| 10 |
RENAISSANCE TECHNOLOGIES LLC |
385,483 |
883,000 |
4.09% |
|
|
| 11 |
TANG CAPITAL MANAGEMENT LLC |
365,000 |
836,000 |
3.87% |
|
|
| 12 |
BLACKROCK ADVISORS LLC |
203,017 |
465,000 |
2.16% |
|
|
| 13 |
Connor, Clark & Lunn Investment Management Ltd. |
194,122 |
445,000 |
2.06% |
|
|
| 14 |
Cheyne Capital Management (UK) LLP |
150,000 |
338,000 |
1.57% |
|
|
| 15 |
D. E. Shaw & Co., Inc. |
142,119 |
325,000 |
1.51% |
|
|
| 16 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
132,774 |
304,000 |
1.41% |
|
|
| 17 |
Nine Chapters Capital Management LLC |
113,700 |
260,000 |
1.21% |
|
|
| 18 |
Tekla Capital Management LLC |
113,100 |
259,000 |
1.20% |
|
|
| 19 |
TWO SIGMA INVESTMENTS, LP |
109,395 |
251,000 |
1.16% |
|
|
| 20 |
MORGAN STANLEY |
104,942 |
240,000 |
1.11% |
|
|
| 21 |
WASATCH ADVISORS LP |
89,815 |
206,000 |
0.95% |
|
|
| 22 |
BOGLE INVESTMENT MANAGEMENT L P /DE/ |
87,388 |
200,000 |
0.93% |
|
|
| 23 |
GOLDMAN SACHS GROUP INC |
75,997 |
174,000 |
0.81% |
|
|
| 24 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
69,500 |
159,000 |
0.74% |
Put |
|
| 25 |
GEODE CAPITAL MANAGEMENT, LLC |
64,641 |
148,000 |
0.69% |
|
|
| 26 |
BlackRock Fund Advisors |
59,145 |
135,000 |
0.63% |
|
|
| 27 |
PUTNAM INVESTMENTS LLC |
50,200 |
115,000 |
0.53% |
|
|
| 28 |
Telemetry Investments, L.L.C. |
50,000 |
114,000 |
0.53% |
|
|
| 29 |
STONERIDGE INVESTMENT PARTNERS LLC |
49,471 |
113,000 |
0.52% |
|
|
| 30 |
NORTHERN TRUST CORP |
47,721 |
110,000 |
0.51% |
|
|
| 31 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
48,944 |
102,000 |
0.47% |
|
|
| 32 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
43,214 |
99,000 |
0.46% |
|
|
| 33 |
DEUTSCHE BANK AG\ |
38,618 |
88,000 |
0.41% |
|
|
| 34 |
DIMENSIONAL FUND ADVISORS LP |
37,214 |
85,000 |
0.39% |
|
|
| 35 |
TWO SIGMA ADVISERS, LP |
36,684 |
84,000 |
0.39% |
|
|
| 36 |
RUSSELL FRANK CO/ |
31,661 |
71,000 |
0.33% |
|
|
| 37 |
ClariVest Asset Management LLC |
27,686 |
63,000 |
0.29% |
|
|
| 38 |
PRICE T ROWE ASSOCIATES INC /MD/ |
24,500 |
56,000 |
0.26% |
|
|
| 39 |
MILLENNIUM MANAGEMENT LLC |
21,622 |
50,000 |
0.23% |
|
|
| 40 |
BANK OF AMERICA CORP /DE/ |
21,449 |
49,000 |
0.23% |
|
|
| 41 |
Virtu KCG Holdings LLC |
20,740 |
47,000 |
0.22% |
|
|
| 42 |
Rotella Capital Management, Inc. |
19,473 |
45,000 |
0.21% |
|
|
| 43 |
KEYBANK NATIONAL ASSOCIATION/OH |
18,531 |
42,000 |
0.19% |
|
|
| 44 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
17,000 |
39,000 |
0.18% |
Call |
|
| 45 |
Bank of New York Mellon Corp |
17,133 |
39,000 |
0.18% |
|
|
| 46 |
GROUP ONE TRADING LLC |
16,242 |
37,000 |
0.17% |
|
|
| 47 |
CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. |
13,600 |
31,000 |
0.14% |
|
|
| 48 |
STATE STREET CORP |
13,029 |
30,000 |
0.14% |
|
|
| 49 |
STIFEL FINANCIAL CORP |
10,455 |
24,000 |
0.11% |
|
|
| 50 |
CITIGROUP INC |
10,719 |
24,000 |
0.11% |
|
|
