| 1 |
BAUPOST GROUP LLC/MA |
4,763,265 |
192,802,000 |
41.78% |
|
|
| 2 |
EcoR1 Capital, LLC |
1,063,189 |
44,197,000 |
9.58% |
|
|
| 3 |
Visium Asset Management, LP |
910,000 |
37,828,000 |
8.20% |
|
|
| 4 |
FMR LLC |
693,833 |
28,843,000 |
6.25% |
|
|
| 5 |
JENNISON ASSOCIATES LLC |
594,758 |
24,724,000 |
5.36% |
|
|
| 6 |
BRIDGER MANAGEMENT, LLC |
474,835 |
19,739,000 |
4.28% |
|
|
| 7 |
Neuberger Berman Group LLC |
446,777 |
18,573,000 |
4.02% |
|
|
| 8 |
Redmile Group, LLC |
265,205 |
11,025,000 |
2.39% |
|
|
| 9 |
EverPoint Asset Management, LLC |
252,349 |
10,490,000 |
2.27% |
|
|
| 10 |
VANGUARD GROUP INC |
216,488 |
8,999,000 |
1.95% |
|
|
| 11 |
BlackRock Fund Advisors |
193,726 |
8,053,000 |
1.74% |
|
|
| 12 |
TIVERTON ASSET MANAGEMENT LLC |
190,000 |
7,898,000 |
1.71% |
|
|
| 13 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
154,124 |
6,407,000 |
1.39% |
|
|
| 14 |
JPMORGAN CHASE & CO |
144,150 |
5,993,000 |
1.30% |
|
|
| 15 |
ArrowMark Colorado Holdings LLC |
122,134 |
5,077,000 |
1.10% |
|
|
| 16 |
BAMCO INC /NY/ |
120,844 |
5,023,000 |
1.09% |
|
|
| 17 |
BlackRock Institutional Trust Company, N.A. |
72,857 |
3,029,000 |
0.66% |
|
|
| 18 |
STATE STREET CORP |
71,612 |
2,974,000 |
0.64% |
|
|
| 19 |
NORTHERN TRUST CORP |
69,912 |
2,906,000 |
0.63% |
|
|
| 20 |
SPHERA FUNDS MANAGEMENT LTD. |
63,579 |
2,643,000 |
0.57% |
|
|
| 21 |
GEODE CAPITAL MANAGEMENT, LLC |
57,002 |
2,369,000 |
0.51% |
|
|
| 22 |
Bank of New York Mellon Corp |
29,978 |
1,246,000 |
0.27% |
|
|
| 23 |
CITIGROUP INC |
26,151 |
1,087,000 |
0.24% |
|
|
| 24 |
Point72 Asset Management, L.P. |
25,100 |
1,043,000 |
0.23% |
|
|
| 25 |
NORGES BANK |
25,010 |
1,040,000 |
0.23% |
|
|
| 26 |
Absolute Return Capital, LLC |
23,986 |
997,000 |
0.22% |
|
|
| 27 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
21,015 |
874,000 |
0.19% |
|
|
| 28 |
BlackRock Investment Management, LLC |
20,353 |
846,000 |
0.18% |
|
|
| 29 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
19,121 |
795,000 |
0.17% |
|
|
| 30 |
BOGLE INVESTMENT MANAGEMENT L P /DE/ |
13,643 |
567,000 |
0.12% |
|
|
| 31 |
A.R.T. Advisors, LLC |
12,624 |
524,000 |
0.11% |
|
|
| 32 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
12,600 |
524,000 |
0.11% |
|
|
| 33 |
CADENCE CAPITAL MANAGEMENT LLC |
10,265 |
427,000 |
0.09% |
|
|
| 34 |
TEACHERS ADVISORS, LLC |
9,803 |
408,000 |
0.09% |
|
|
| 35 |
ALLIANCEBERNSTEIN L.P. |
6,100 |
254,000 |
0.06% |
|
|
| 36 |
FRED ALGER MANAGEMENT, LLC |
5,400 |
224,000 |
0.05% |
|
|
| 37 |
BLACKROCK ADVISORS LLC |
4,857 |
202,000 |
0.04% |
|
|
| 38 |
Nationwide Fund Advisors |
4,531 |
188,000 |
0.04% |
|
|
| 39 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,615 |
150,276 |
0.03% |
|
|
| 40 |
B. Riley Wealth Management, Inc. |
3,000 |
124,000 |
0.03% |
|
|
| 41 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
2,741 |
114,000 |
0.02% |
|
|
| 42 |
STRS OHIO |
2,300 |
95,000 |
0.02% |
|
|
| 43 |
Cubist Systematic Strategies, LLC |
1,717 |
71,000 |
0.02% |
|
|
| 44 |
UBS Group AG |
1,000 |
42,000 |
0.01% |
|
|
| 45 |
WELLS FARGO & COMPANY/MN |
1,015 |
42,000 |
0.01% |
|
|
| 46 |
BARCLAYS PLC |
209 |
8,000 |
0.00% |
|
|
| 47 |
Tower Research Capital LLC (TRC) |
183 |
8,000 |
0.00% |
|
|
| 48 |
BNP PARIBAS FINANCIAL MARKETS |
161 |
6,693 |
0.00% |
|
|
| 49 |
BlackRock Finance, Inc. |
148 |
6,000 |
0.00% |
|
|
| 50 |
MORGAN STANLEY |
90 |
4,000 |
0.00% |
|
|
