| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAUPOST GROUP LLC/MA | 5,359,632 | 76,107,000 | 23.07% | ||
| 2 | FMR LLC | 2,782,447 | 39,512,000 | 11.98% | ||
| 3 | Redmile Group, LLC | 2,670,942 | 37,927,000 | 11.50% | ||
| 4 | ArrowMark Colorado Holdings LLC | 1,560,612 | 22,161,000 | 6.72% | ||
| 5 | BlackRock Fund Advisors | 1,111,507 | 15,783,000 | 4.78% | ||
| 6 | EAGLE ASSET MANAGEMENT INC | 1,110,698 | 15,771,000 | 4.78% | ||
| 7 | BRIDGER MANAGEMENT, LLC | 798,321 | 11,336,000 | 3.44% | ||
| 8 | VANGUARD GROUP INC | 750,291 | 10,653,000 | 3.23% | ||
| 9 | Neuberger Berman Group LLC | 750,140 | 10,652,000 | 3.23% | ||
| 10 | STATE STREET CORP | 600,521 | 8,526,000 | 2.58% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 506,378 | 7,191,000 | 2.18% | ||
| 12 | Artal Group S.A. | 500,000 | 7,100,000 | 2.15% | ||
| 13 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 475,172 | 6,747,000 | 2.05% | ||
| 14 | Slate Path Capital LP | 475,000 | 6,745,000 | 2.04% | ||
| 15 | Alyeska Investment Group, L.P. | 408,200 | 5,796,000 | 1.76% | ||
| 16 | 12 West Capital Management LP | 398,700 | 5,662,000 | 1.72% | ||
| 17 | RTW INVESTMENTS, LP | 372,624 | 5,291,000 | 1.60% | ||
| 18 | NORGES BANK | 283,882 | 4,031,000 | 1.22% | ||
| 19 | NORTHERN TRUST CORP | 259,895 | 3,690,000 | 1.12% | ||
| 20 | EcoR1 Capital, LLC | 215,812 | 3,065,000 | 0.93% | ||
| 21 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 179,000 | 2,542,000 | 0.77% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 166,408 | 2,362,000 | 0.72% | ||
| 23 | TEACHERS ADVISORS, LLC | 137,416 | 1,951,000 | 0.59% | ||
| 24 | BANK OF AMERICA CORP /DE/ | 117,973 | 1,675,000 | 0.51% | ||
| 25 | Bank of New York Mellon Corp | 114,028 | 1,620,000 | 0.49% | ||
| 26 | BlackRock Investment Management, LLC | 92,922 | 1,319,000 | 0.40% | ||
| 27 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 75,134 | 1,067,000 | 0.32% | ||
| 28 | MORGAN STANLEY | 70,689 | 1,004,000 | 0.30% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 68,179 | 968,000 | 0.29% | ||
| 30 | WELLS FARGO & COMPANY/MN | 53,461 | 759,000 | 0.23% | ||
| 31 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 47,904 | 680,000 | 0.21% | ||
| 32 | Vident Investment Advisory, LLC | 46,389 | 659,000 | 0.20% | ||
| 33 | CITIGROUP INC | 44,153 | 627,000 | 0.19% | ||
| 34 | TIVERTON ASSET MANAGEMENT LLC | 42,298 | 600,000 | 0.18% | ||
| 35 | CREDIT SUISSE AG/ | 38,350 | 544,000 | 0.16% | ||
| 36 | GOLDMAN SACHS GROUP INC | 28,030 | 398,000 | 0.12% | ||
| 37 | ALPS ADVISORS INC | 27,736 | 394,000 | 0.12% | ||
| 38 | RHUMBLINE ADVISERS | 27,350 | 388,000 | 0.12% | ||
| 39 | MILLENNIUM MANAGEMENT LLC | 26,335 | 374,000 | 0.11% | ||
| 40 | Swiss National Bank | 26,100 | 371,000 | 0.11% | ||
| 41 | NEW YORK STATE COMMON RETIREMENT FUND | 24,700 | 351,000 | 0.11% | ||
| 42 | ProShare Advisors LLC | 22,796 | 324,000 | 0.10% | ||
| 43 | DIMENSIONAL FUND ADVISORS LP | 21,797 | 310,000 | 0.09% | ||
| 44 | ALLIANCEBERNSTEIN L.P. | 21,040 | 299,000 | 0.09% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 18,415 | 261,000 | 0.08% | ||
| 46 | RAYMOND JAMES & ASSOCIATES | 18,021 | 256,000 | 0.08% | ||
| 47 | METROPOLITAN LIFE INSURANCE CO/NY | 17,716 | 252,000 | 0.08% | ||
| 48 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,456 | 234,000 | 0.07% | ||
| 49 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 15,615 | 222,000 | 0.07% | ||
| 50 | Nationwide Fund Advisors | 14,285 | 203,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
