| 1 |
BAUPOST GROUP LLC/MA |
4,809,632 |
253,756,000 |
37.34% |
|
|
| 2 |
EcoR1 Capital, LLC |
1,063,189 |
56,094,000 |
8.25% |
|
|
| 3 |
FMR LLC |
997,959 |
52,652,000 |
7.75% |
|
|
| 4 |
Visium Asset Management, LP |
904,514 |
47,722,000 |
7.02% |
|
|
| 5 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
619,509 |
32,685,000 |
4.81% |
|
|
| 6 |
JENNISON ASSOCIATES LLC |
599,485 |
31,629,000 |
4.65% |
|
|
| 7 |
BRIDGER MANAGEMENT, LLC |
501,297 |
26,448,000 |
3.89% |
|
|
| 8 |
Neuberger Berman Group LLC |
446,020 |
23,532,000 |
3.46% |
|
|
| 9 |
Redmile Group, LLC |
372,642 |
19,661,000 |
2.89% |
|
|
| 10 |
VANGUARD GROUP INC |
352,709 |
18,609,000 |
2.74% |
|
|
| 11 |
BlackRock Fund Advisors |
346,203 |
18,266,000 |
2.69% |
|
|
| 12 |
TIVERTON ASSET MANAGEMENT LLC |
225,113 |
11,877,000 |
1.75% |
|
|
| 13 |
JPMORGAN CHASE & CO |
200,700 |
10,589,000 |
1.56% |
|
|
| 14 |
BlackRock Institutional Trust Company, N.A. |
183,679 |
9,691,000 |
1.43% |
|
|
| 15 |
ArrowMark Colorado Holdings LLC |
123,668 |
6,525,000 |
0.96% |
|
|
| 16 |
Ghost Tree Capital, LLC |
100,000 |
5,276,000 |
0.78% |
|
|
| 17 |
TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY |
85,700 |
4,522,000 |
0.67% |
|
|
| 18 |
NORTHERN TRUST CORP |
84,384 |
4,452,000 |
0.66% |
|
|
| 19 |
Cupps Capital Management, LLC |
78,660 |
4,150,000 |
0.61% |
|
|
| 20 |
Bank of New York Mellon Corp |
76,044 |
4,012,000 |
0.59% |
|
|
| 21 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
65,245 |
3,442,000 |
0.51% |
|
|
| 22 |
GEODE CAPITAL MANAGEMENT, LLC |
64,431 |
3,399,000 |
0.50% |
|
|
| 23 |
Cormorant Asset Management, LP |
50,000 |
2,638,000 |
0.39% |
|
|
| 24 |
BlackRock Investment Management, LLC |
48,860 |
2,578,000 |
0.38% |
|
|
| 25 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
30,796 |
1,625,000 |
0.24% |
|
|
| 26 |
RUSSELL FRANK CO/ |
30,457 |
1,607,000 |
0.24% |
|
|
| 27 |
Absolute Return Capital, LLC |
29,945 |
1,580,000 |
0.23% |
|
|
| 28 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
26,464 |
1,396,000 |
0.21% |
|
|
| 29 |
NORGES BANK |
25,010 |
1,320,000 |
0.19% |
|
|
| 30 |
ALPS ADVISORS INC |
24,142 |
1,274,000 |
0.19% |
|
|
| 31 |
ALLIANCEBERNSTEIN L.P. |
21,500 |
1,134,000 |
0.17% |
|
|
| 32 |
TEACHERS ADVISORS, LLC |
21,108 |
1,114,000 |
0.16% |
|
|
| 33 |
CADENCE CAPITAL MANAGEMENT LLC |
18,160 |
958,000 |
0.14% |
|
|
| 34 |
Informed Momentum Co LLC |
17,932 |
946,000 |
0.14% |
|
|
| 35 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
15,700 |
828,000 |
0.12% |
Put |
|
| 36 |
TWO SIGMA INVESTMENTS, LP |
15,473 |
816,000 |
0.12% |
|
|
| 37 |
Candriam S.C.A. |
15,000 |
791,000 |
0.12% |
|
|
| 38 |
Swiss National Bank |
14,000 |
739,000 |
0.11% |
|
|
| 39 |
SCHRODER INVESTMENT MANAGEMENT GROUP |
13,789 |
711,000 |
0.10% |
|
|
| 40 |
RHUMBLINE ADVISERS |
12,400 |
654,000 |
0.10% |
|
|
| 41 |
NEW YORK STATE COMMON RETIREMENT FUND |
12,078 |
637,000 |
0.09% |
|
|
| 42 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
10,300 |
543,000 |
0.08% |
Call |
|
| 43 |
METROPOLITAN LIFE INSURANCE CO/NY |
10,256 |
541,000 |
0.08% |
|
|
| 44 |
D. E. Shaw & Co., Inc. |
10,000 |
528,000 |
0.08% |
Put |
|
| 45 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
9,583 |
505,000 |
0.07% |
|
|
| 46 |
M&T BANK CORP |
9,380 |
495,000 |
0.07% |
|
|
| 47 |
Nationwide Fund Advisors |
9,368 |
494,000 |
0.07% |
|
|
| 48 |
AMERICAN INTERNATIONAL GROUP, INC. |
8,992 |
474,418 |
0.07% |
|
|
| 49 |
BLACKROCK ADVISORS LLC |
8,747 |
461,000 |
0.07% |
|
|
| 50 |
VOYA INVESTMENT MANAGEMENT LLC |
7,035 |
371,000 |
0.05% |
|
|
