| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAUPOST GROUP LLC/MA | 5,359,632 | 110,140,000 | 22.32% | ||
| 2 | Redmile Group, LLC | 2,734,118 | 56,186,000 | 11.39% | ||
| 3 | FMR LLC | 1,965,768 | 40,397,000 | 8.19% | ||
| 4 | ArrowMark Colorado Holdings LLC | 1,931,522 | 39,693,000 | 8.05% | ||
| 5 | BlackRock Finance, Inc. | 1,726,197 | 35,474,000 | 7.19% | ||
| 6 | BRIDGER MANAGEMENT, LLC | 1,408,905 | 28,953,000 | 5.87% | ||
| 7 | EAGLE ASSET MANAGEMENT INC | 1,267,609 | 26,049,000 | 5.28% | ||
| 8 | RTW INVESTMENTS, LP | 908,733 | 18,674,000 | 3.79% | ||
| 9 | Neuberger Berman Group LLC | 836,515 | 17,190,000 | 3.48% | ||
| 10 | VANGUARD GROUP INC | 831,925 | 17,095,000 | 3.47% | ||
| 11 | STATE STREET CORP | 614,785 | 12,634,000 | 2.56% | ||
| 12 | Artal Group S.A. | 500,000 | 10,275,000 | 2.08% | ||
| 13 | EcoR1 Capital, LLC | 434,812 | 8,935,000 | 1.81% | ||
| 14 | 12 West Capital Management LP | 398,700 | 8,193,000 | 1.66% | ||
| 15 | Alyeska Investment Group, L.P. | 332,925 | 6,842,000 | 1.39% | ||
| 16 | NORGES BANK | 283,882 | 5,834,000 | 1.18% | ||
| 17 | NORTHERN TRUST CORP | 266,674 | 5,480,000 | 1.11% | ||
| 18 | GOLDMAN SACHS GROUP INC | 201,214 | 4,135,000 | 0.84% | ||
| 19 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 179,000 | 3,678,000 | 0.75% | ||
| 20 | MORGAN STANLEY | 175,058 | 3,597,000 | 0.73% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 173,639 | 3,568,000 | 0.72% | ||
| 22 | BANK OF AMERICA CORP /DE/ | 130,645 | 2,684,000 | 0.54% | ||
| 23 | Camber Capital Management LP | 125,000 | 2,569,000 | 0.52% | ||
| 24 | Bank of New York Mellon Corp | 120,097 | 2,468,000 | 0.50% | ||
| 25 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 79,580 | 1,636,000 | 0.33% | ||
| 26 | CITADEL ADVISORS LLC | 63,570 | 1,306,000 | 0.26% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 63,231 | 1,299,000 | 0.26% | ||
| 28 | WELLS FARGO & COMPANY/MN | 58,252 | 1,197,000 | 0.24% | ||
| 29 | Vident Investment Advisory, LLC | 55,665 | 1,144,000 | 0.23% | ||
| 30 | TEACHERS ADVISORS, LLC | 46,046 | 946,000 | 0.19% | ||
| 31 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 45,704 | 939,000 | 0.19% | ||
| 32 | TIVERTON ASSET MANAGEMENT LLC | 42,298 | 869,000 | 0.18% | ||
| 33 | JENNISON ASSOCIATES LLC | 40,359 | 829,000 | 0.17% | ||
| 34 | FRANKLIN STREET ADVISORS INC /NC | 30,790 | 633,000 | 0.13% | ||
| 35 | CREDIT SUISSE AG/ | 28,739 | 591,000 | 0.12% | ||
| 36 | Swiss National Bank | 28,600 | 588,000 | 0.12% | ||
| 37 | RHUMBLINE ADVISERS | 28,198 | 579,000 | 0.12% | ||
| 38 | TOKIO MARINE ASSET MANAGEMENT CO LTD | 27,000 | 555,000 | 0.11% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 25,700 | 528,000 | 0.11% | Call | |
| 40 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 25,389 | 522,000 | 0.11% | ||
| 41 | Old West Investment Management, LLC | 24,924 | 512,000 | 0.10% | ||
| 42 | ALPS ADVISORS INC | 24,829 | 510,000 | 0.10% | ||
| 43 | NEW YORK STATE COMMON RETIREMENT FUND | 24,701 | 508,000 | 0.10% | ||
| 44 | DIMENSIONAL FUND ADVISORS LP | 21,108 | 434,000 | 0.09% | ||
| 45 | RAYMOND JAMES & ASSOCIATES | 20,303 | 417,000 | 0.08% | ||
| 46 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 19,008 | 391,000 | 0.08% | ||
| 47 | ALLIANCEBERNSTEIN L.P. | 18,540 | 381,000 | 0.08% | ||
| 48 | ProShare Advisors LLC | 18,079 | 372,000 | 0.08% | ||
| 49 | Invesco Ltd. | 17,834 | 366,000 | 0.07% | ||
| 50 | METROPOLITAN LIFE INSURANCE CO/NY | 17,716 | 364,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
