| 1 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
2,765,675 |
45,412,000 |
31.67% |
|
|
| 2 |
FMR LLC |
2,132,700 |
35,019,000 |
24.42% |
|
|
| 3 |
PRICE T ROWE ASSOCIATES INC /MD/ |
1,241,266 |
20,382,000 |
14.22% |
|
|
| 4 |
WELLINGTON MANAGEMENT GROUP LLP |
594,455 |
9,761,000 |
6.81% |
|
|
| 5 |
New Leaf Venture Partners, L.L.C. |
556,036 |
5,225,000 |
3.64% |
|
|
| 6 |
EcoR1 Capital, LLC |
295,480 |
4,852,000 |
3.38% |
|
|
| 7 |
VANGUARD GROUP INC |
262,880 |
4,317,000 |
3.01% |
|
|
| 8 |
EverPoint Asset Management, LLC |
203,718 |
3,345,000 |
2.33% |
|
|
| 9 |
Candriam S.C.A. |
190,000 |
3,121,000 |
2.18% |
|
|
| 10 |
JENNISON ASSOCIATES LLC |
164,834 |
2,707,000 |
1.89% |
|
|
| 11 |
JPMORGAN CHASE & CO |
127,475 |
2,093,000 |
1.46% |
|
|
| 12 |
NORTHERN TRUST CORP |
81,087 |
1,331,000 |
0.93% |
|
|
| 13 |
STATE STREET CORP |
79,918 |
1,311,000 |
0.91% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
50,981 |
837,000 |
0.58% |
|
|
| 15 |
Bank of New York Mellon Corp |
31,339 |
515,000 |
0.36% |
|
|
| 16 |
Spark Investment Management LLC |
29,300 |
480,000 |
0.33% |
|
|
| 17 |
MILLENNIUM MANAGEMENT LLC |
25,230 |
414,000 |
0.29% |
|
|
| 18 |
FRED ALGER MANAGEMENT, LLC |
21,250 |
349,000 |
0.24% |
|
|
| 19 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
15,018 |
247,000 |
0.17% |
|
|
| 20 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
14,500 |
238,000 |
0.17% |
|
|
| 21 |
CITIGROUP INC |
12,961 |
212,000 |
0.15% |
|
|
| 22 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
11,300 |
186,000 |
0.13% |
|
|
| 23 |
TEACHERS ADVISORS, LLC |
10,595 |
174,000 |
0.12% |
|
|
| 24 |
TD ASSET MANAGEMENT INC |
10,100 |
166,000 |
0.12% |
|
|
| 25 |
BANK OF MONTREAL /CAN/ |
7,000 |
115,000 |
0.08% |
|
|
| 26 |
Amici Capital, LLC |
6,360 |
104,000 |
0.07% |
|
|
| 27 |
Nationwide Fund Advisors |
5,938 |
98,000 |
0.07% |
|
|
| 28 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
5,500 |
90,000 |
0.06% |
|
|
| 29 |
AMERICAN INTERNATIONAL GROUP, INC. |
5,030 |
82,593 |
0.06% |
|
|
| 30 |
ALLIANCEBERNSTEIN L.P. |
4,100 |
67,000 |
0.05% |
|
|
| 31 |
STRS OHIO |
2,700 |
44,000 |
0.03% |
|
|
| 32 |
Cubist Systematic Strategies, LLC |
2,024 |
33,000 |
0.02% |
|
|
| 33 |
WELLS FARGO & COMPANY/MN |
1,557 |
26,000 |
0.02% |
|
|
| 34 |
Tower Research Capital LLC (TRC) |
525 |
9,000 |
0.01% |
|
|
| 35 |
MORGAN STANLEY |
300 |
5,000 |
0.00% |
|
|
| 36 |
BARCLAYS PLC |
243 |
4,000 |
0.00% |
|
|
| 37 |
BNP PARIBAS FINANCIAL MARKETS |
182 |
2,988 |
0.00% |
|
|
| 38 |
PNC FINANCIAL SERVICES GROUP, INC. |
3 |
0 |
0.00% |
|
|
| 39 |
BANK OF AMERICA CORP /DE/ |
19 |
0 |
0.00% |
|
|
| 40 |
SUMMIT SECURITIES GROUP LLC |
3 |
0 |
0.00% |
|
|
| 41 |
DEUTSCHE BANK AG\ |
20 |
0 |
0.00% |
|
|
