| 1 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
3,135,069 |
17,023,000 |
34.40% |
|
|
| 2 |
FMR LLC |
2,691,958 |
14,618,000 |
29.54% |
|
|
| 3 |
BVF INC/IL |
456,500 |
2,479,000 |
5.01% |
|
|
| 4 |
VANGUARD GROUP INC |
428,059 |
2,324,000 |
4.70% |
|
|
| 5 |
EcoR1 Capital, LLC |
415,480 |
2,256,000 |
4.56% |
|
|
| 6 |
BlackRock Institutional Trust Company, N.A. |
311,557 |
1,692,000 |
3.42% |
|
|
| 7 |
New Leaf Venture Partners, L.L.C. |
299,583 |
1,627,000 |
3.29% |
|
|
| 8 |
BlackRock Fund Advisors |
275,678 |
1,497,000 |
3.03% |
|
|
| 9 |
Candriam S.C.A. |
194,999 |
1,059,000 |
2.14% |
|
|
| 10 |
FRED ALGER MANAGEMENT, LLC |
118,990 |
646,000 |
1.31% |
|
|
| 11 |
NORTHERN TRUST CORP |
99,274 |
539,000 |
1.09% |
|
|
| 12 |
STATE STREET CORP |
93,664 |
510,000 |
1.03% |
|
|
| 13 |
GEODE CAPITAL MANAGEMENT, LLC |
60,722 |
329,000 |
0.66% |
|
|
| 14 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
42,600 |
231,000 |
0.47% |
Put |
|
| 15 |
BlackRock Investment Management, LLC |
42,393 |
230,000 |
0.46% |
|
|
| 16 |
DEUTSCHE BANK AG\ |
40,694 |
219,000 |
0.44% |
|
|
| 17 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
39,055 |
212,000 |
0.43% |
|
|
| 18 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
33,400 |
181,000 |
0.37% |
Call |
|
| 19 |
Bank of New York Mellon Corp |
33,436 |
181,000 |
0.37% |
|
|
| 20 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
30,500 |
166,000 |
0.34% |
|
|
| 21 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
25,185 |
137,000 |
0.28% |
|
|
| 22 |
Trexquant Investment LP |
24,476 |
132,000 |
0.27% |
|
|
| 23 |
Virtu KCG Holdings LLC |
22,069 |
120,000 |
0.24% |
|
|
| 24 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
20,127 |
109,000 |
0.22% |
|
|
| 25 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
19,000 |
104,000 |
0.21% |
|
|
| 26 |
Airain ltd |
17,764 |
96,000 |
0.19% |
|
|
| 27 |
PRICE T ROWE ASSOCIATES INC /MD/ |
17,250 |
94,000 |
0.19% |
|
|
| 28 |
TEACHERS ADVISORS, LLC |
15,800 |
86,000 |
0.17% |
|
|
| 29 |
RHUMBLINE ADVISERS |
13,876 |
75,000 |
0.15% |
|
|
| 30 |
HOWLAND CAPITAL MANAGEMENT LLC |
13,456 |
73,000 |
0.15% |
|
|
| 31 |
BlackRock Group LTD |
12,617 |
69,000 |
0.14% |
|
|
| 32 |
NEW YORK STATE COMMON RETIREMENT FUND |
10,100 |
55,000 |
0.11% |
|
|
| 33 |
BLACKROCK ADVISORS LLC |
8,155 |
44,000 |
0.09% |
|
|
| 34 |
Nationwide Fund Advisors |
7,169 |
39,000 |
0.08% |
|
|
| 35 |
Amici Capital, LLC |
6,360 |
35,000 |
0.07% |
|
|
| 36 |
AMERICAN INTERNATIONAL GROUP, INC. |
6,497 |
35,000 |
0.07% |
|
|
| 37 |
ADVANTAGE INVESTMENT MANAGEMENT, LLC |
6,300 |
34,000 |
0.07% |
|
|
| 38 |
CITADEL ADVISORS LLC |
4,381 |
24,000 |
0.05% |
|
|
| 39 |
WELLS FARGO & COMPANY/MN |
3,796 |
20,000 |
0.04% |
|
|
| 40 |
MAZAMA CAPITAL MANAGEMENT INC |
3,676 |
20,000 |
0.04% |
|
|
| 41 |
Tower Research Capital LLC (TRC) |
2,959 |
16,000 |
0.03% |
|
|
| 42 |
BNP PARIBAS FINANCIAL MARKETS |
2,682 |
14,563 |
0.03% |
|
|
| 43 |
MORGAN STANLEY |
2,512 |
14,000 |
0.03% |
|
|
| 44 |
SIMPLEX TRADING, LLC |
1,851 |
10,000 |
0.02% |
|
|
| 45 |
ROYAL BANK OF CANADA |
412 |
2,000 |
0.00% |
|
|
| 46 |
BlackRock Finance, Inc. |
227 |
1,000 |
0.00% |
|
|
| 47 |
CITIGROUP INC |
125 |
1,000 |
0.00% |
|
|
| 48 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
108 |
1,000 |
0.00% |
|
|
| 49 |
BANK OF AMERICA CORP /DE/ |
28 |
0 |
0.00% |
|
|
| 50 |
BARCLAYS PLC |
58 |
0 |
0.00% |
|
|
