| 1 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
2,765,675 |
19,747,000 |
34.05% |
|
|
| 2 |
FMR LLC |
2,691,958 |
19,220,000 |
33.14% |
|
|
| 3 |
EcoR1 Capital, LLC |
415,480 |
2,967,000 |
5.12% |
|
|
| 4 |
Numeric Investors LLC |
335,343 |
2,394,000 |
4.13% |
|
|
| 5 |
VANGUARD GROUP INC |
279,224 |
1,994,000 |
3.44% |
|
|
| 6 |
BlackRock Fund Advisors |
273,874 |
1,955,000 |
3.37% |
|
|
| 7 |
Candriam S.C.A. |
230,000 |
1,642,000 |
2.83% |
|
|
| 8 |
BlackRock Institutional Trust Company, N.A. |
153,632 |
1,097,000 |
1.89% |
|
|
| 9 |
New Leaf Venture Partners, L.L.C. |
135,890 |
970,000 |
1.67% |
|
|
| 10 |
STATE STREET CORP |
83,182 |
595,000 |
1.03% |
|
|
| 11 |
NORTHERN TRUST CORP |
81,222 |
580,000 |
1.00% |
|
|
| 12 |
ELLINGTON MANAGEMENT GROUP LLC |
79,884 |
570,000 |
0.98% |
|
|
| 13 |
GEODE CAPITAL MANAGEMENT, LLC |
53,790 |
384,000 |
0.66% |
|
|
| 14 |
FRED ALGER MANAGEMENT, LLC |
52,250 |
373,000 |
0.64% |
|
|
| 15 |
BlackRock Investment Management, LLC |
42,393 |
303,000 |
0.52% |
|
|
| 16 |
Bank of New York Mellon Corp |
41,185 |
294,000 |
0.51% |
|
|
| 17 |
DEUTSCHE BANK AG\ |
40,779 |
289,000 |
0.50% |
|
|
| 18 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
39,055 |
279,000 |
0.48% |
|
|
| 19 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
28,300 |
202,000 |
0.35% |
Put |
|
| 20 |
GOLDMAN SACHS GROUP INC |
23,576 |
168,000 |
0.29% |
|
|
| 21 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
20,227 |
144,000 |
0.25% |
|
|
| 22 |
Birchview Capital, LP |
19,700 |
141,000 |
0.24% |
|
|
| 23 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
19,000 |
136,000 |
0.23% |
|
|
| 24 |
TFS CAPITAL LLC |
17,145 |
122,000 |
0.21% |
|
|
| 25 |
PRICE T ROWE ASSOCIATES INC /MD/ |
16,700 |
119,000 |
0.21% |
|
|
| 26 |
TEACHERS ADVISORS, LLC |
15,800 |
113,000 |
0.19% |
|
|
| 27 |
Verition Fund Management LLC |
15,155 |
108,000 |
0.19% |
|
|
| 28 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
14,805 |
106,000 |
0.18% |
|
|
| 29 |
HOWLAND CAPITAL MANAGEMENT LLC |
13,456 |
96,000 |
0.17% |
|
|
| 30 |
RHUMBLINE ADVISERS |
13,140 |
94,000 |
0.16% |
|
|
| 31 |
CREDIT SUISSE AG/ |
13,153 |
94,000 |
0.16% |
|
|
| 32 |
BlackRock Group LTD |
12,617 |
90,000 |
0.16% |
|
|
| 33 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC |
12,558 |
90,000 |
0.16% |
|
|
| 34 |
NEW YORK STATE COMMON RETIREMENT FUND |
10,100 |
72,000 |
0.12% |
|
|
| 35 |
PNC FINANCIAL SERVICES GROUP, INC. |
10,005 |
71,000 |
0.12% |
|
|
| 36 |
HAMILTON LANE ADVISORS LLC |
10,000 |
71,000 |
0.12% |
|
|
| 37 |
BLACKROCK ADVISORS LLC |
8,155 |
58,000 |
0.10% |
|
|
| 38 |
Nationwide Fund Advisors |
7,169 |
51,000 |
0.09% |
|
|
| 39 |
WELLS FARGO & COMPANY/MN |
6,554 |
47,000 |
0.08% |
|
|
| 40 |
AMERICAN INTERNATIONAL GROUP, INC. |
6,490 |
46,339 |
0.08% |
|
|
| 41 |
Amici Capital, LLC |
6,360 |
45,000 |
0.08% |
|
|
| 42 |
STRS OHIO |
2,700 |
19,000 |
0.03% |
|
|
| 43 |
SIMPLEX TRADING, LLC |
1,237 |
8,000 |
0.01% |
|
|
| 44 |
MORGAN STANLEY |
1,027 |
7,000 |
0.01% |
|
|
| 45 |
BNP PARIBAS FINANCIAL MARKETS |
921 |
6,576 |
0.01% |
|
|
| 46 |
ROYAL BANK OF CANADA |
648 |
5,000 |
0.01% |
|
|
| 47 |
Invesco Ltd. |
624 |
4,000 |
0.01% |
|
|
| 48 |
BlackRock Finance, Inc. |
227 |
2,000 |
0.00% |
|
|
| 49 |
BARCLAYS PLC |
214 |
1,000 |
0.00% |
|
|
| 50 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
108 |
1,000 |
0.00% |
|
|
