| 1 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
3,135,069 |
24,015,000 |
27.65% |
|
|
| 2 |
FMR LLC |
2,691,958 |
20,620,000 |
23.74% |
|
|
| 3 |
MORGENTHALER MANAGEMENT PARTNERS IX, LLC |
2,161,915 |
16,560,000 |
19.07% |
|
|
| 4 |
VANGUARD GROUP INC |
433,195 |
3,318,000 |
3.82% |
|
|
| 5 |
EcoR1 Capital, LLC |
415,480 |
3,183,000 |
3.67% |
|
|
| 6 |
BlackRock Institutional Trust Company, N.A. |
314,249 |
2,407,000 |
2.77% |
|
|
| 7 |
BlackRock Fund Advisors |
285,313 |
2,185,000 |
2.52% |
|
|
| 8 |
JPMORGAN CHASE & CO |
274,500 |
2,103,000 |
2.42% |
|
|
| 9 |
First Eagle Investment Management, LLC |
205,369 |
1,573,000 |
1.81% |
|
|
| 10 |
Candriam S.C.A. |
194,999 |
1,494,000 |
1.72% |
|
|
| 11 |
BVF INC/IL |
167,900 |
1,286,000 |
1.48% |
|
|
| 12 |
NORTHERN TRUST CORP |
103,411 |
792,000 |
0.91% |
|
|
| 13 |
STATE STREET CORP |
93,556 |
717,000 |
0.83% |
|
|
| 14 |
FRED ALGER MANAGEMENT, LLC |
83,990 |
643,000 |
0.74% |
|
|
| 15 |
Nationwide Fund Advisors |
79,169 |
606,000 |
0.70% |
|
|
| 16 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
77,850 |
596,000 |
0.69% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
61,964 |
474,000 |
0.55% |
|
|
| 18 |
Bank of New York Mellon Corp |
51,414 |
394,000 |
0.45% |
|
|
| 19 |
BlackRock Investment Management, LLC |
42,534 |
326,000 |
0.38% |
|
|
| 20 |
PANAGORA ASSET MANAGEMENT INC |
41,590 |
319,000 |
0.37% |
|
|
| 21 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
39,055 |
299,000 |
0.34% |
|
|
| 22 |
LANDSCAPE CAPITAL MANAGEMENT, L.L.C. |
37,434 |
287,000 |
0.33% |
|
|
| 23 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
29,200 |
224,000 |
0.26% |
Call |
|
| 24 |
MILLENNIUM MANAGEMENT LLC |
24,747 |
190,000 |
0.22% |
|
|
| 25 |
AQR CAPITAL MANAGEMENT LLC |
24,353 |
187,000 |
0.22% |
|
|
| 26 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
21,300 |
163,000 |
0.19% |
Put |
|
| 27 |
CITADEL ADVISORS LLC |
20,877 |
160,000 |
0.18% |
|
|
| 28 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
20,500 |
157,000 |
0.18% |
|
|
| 29 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
19,000 |
146,000 |
0.17% |
|
|
| 30 |
Connor, Clark & Lunn Investment Management Ltd. |
15,900 |
122,000 |
0.14% |
|
|
| 31 |
TEACHERS ADVISORS, LLC |
15,800 |
121,000 |
0.14% |
|
|
| 32 |
RHUMBLINE ADVISERS |
14,551 |
111,000 |
0.13% |
|
|
| 33 |
WELLS FARGO & COMPANY/MN |
13,599 |
104,000 |
0.12% |
|
|
| 34 |
HOWLAND CAPITAL MANAGEMENT LLC |
13,456 |
103,000 |
0.12% |
|
|
| 35 |
LPL Financial LLC |
12,820 |
100,000 |
0.12% |
|
|
| 36 |
BlackRock Group LTD |
12,617 |
97,000 |
0.11% |
|
|
| 37 |
Squarepoint Ops LLC |
11,700 |
90,000 |
0.10% |
|
|
| 38 |
DEUTSCHE BANK AG\ |
10,335 |
78,000 |
0.09% |
|
|
| 39 |
NEW YORK STATE COMMON RETIREMENT FUND |
10,100 |
77,000 |
0.09% |
|
|
| 40 |
Spot Trading L.L.C |
10,000 |
77,000 |
0.09% |
Call |
|
| 41 |
MORGAN STANLEY |
9,604 |
74,000 |
0.09% |
|
|
| 42 |
ADVANTAGE INVESTMENT MANAGEMENT, LLC |
6,800 |
52,000 |
0.06% |
|
|
| 43 |
AMERICAN INTERNATIONAL GROUP, INC. |
6,485 |
50,000 |
0.06% |
|
|
| 44 |
BLACKROCK ADVISORS LLC |
5,543 |
42,000 |
0.05% |
|
|
| 45 |
MAZAMA CAPITAL MANAGEMENT INC |
3,676 |
28,000 |
0.03% |
|
|
| 46 |
UBS Group AG |
2,412 |
19,000 |
0.02% |
|
|
| 47 |
CUTLER GROUP LLC / CA |
2,300 |
17,000 |
0.02% |
|
|
| 48 |
Tower Research Capital LLC (TRC) |
2,007 |
15,000 |
0.02% |
|
|
| 49 |
SIMPLEX TRADING, LLC |
1,982 |
15,000 |
0.02% |
|
|
| 50 |
BNP PARIBAS FINANCIAL MARKETS |
1,659 |
12,708 |
0.01% |
|
|
