| 1 |
NEA Management Company, LLC |
1,050,000 |
4,619,000 |
19.87% |
|
|
| 2 |
AWM Investment Company, Inc. |
1,003,522 |
4,415,000 |
18.99% |
|
|
| 3 |
Cormorant Asset Management, LP |
600,000 |
2,640,000 |
11.36% |
|
SH |
| 4 |
JANUS HENDERSON GROUP PLC |
544,293 |
2,395,000 |
10.30% |
|
|
| 5 |
Tekla Capital Management LLC |
500,000 |
1,980,000 |
8.52% |
|
|
| 6 |
BAKER BROS. ADVISORS LP |
413,697 |
1,820,000 |
7.83% |
|
|
| 7 |
New Leaf Venture Partners, L.L.C. |
404,159 |
1,778,000 |
7.65% |
|
|
| 8 |
SECTORAL ASSET MANAGEMENT INC |
183,272 |
806,000 |
3.47% |
|
|
| 9 |
INTERNATIONAL BIOTECHNOLOGY TRUST PLC |
161,069 |
693,000 |
2.98% |
|
|
| 10 |
VICTORY CAPITAL MANAGEMENT INC |
146,571 |
645,000 |
2.77% |
|
|
| 11 |
Candriam S.C.A. |
110,000 |
476,000 |
2.05% |
|
|
| 12 |
K2 PRINCIPAL FUND, L.P. |
60,013 |
264,000 |
1.14% |
|
|
| 13 |
PRELUDE CAPITAL MANAGEMENT, LLC |
29,700 |
131,000 |
0.56% |
|
|
| 14 |
Virtu KCG Holdings LLC |
29,081 |
128,000 |
0.55% |
|
|
| 15 |
Creative Planning |
26,400 |
116,000 |
0.50% |
|
|
| 16 |
FRANKLIN RESOURCES INC |
20,200 |
89,000 |
0.38% |
|
|
| 17 |
DAFNA Capital Management LLC |
20,000 |
88,000 |
0.38% |
|
|
| 18 |
WELLS FARGO & COMPANY/MN |
15,550 |
69,000 |
0.30% |
|
|
| 19 |
DEUTSCHE BANK AG\ |
9,100 |
40,000 |
0.17% |
|
|
| 20 |
MORGAN STANLEY |
6,770 |
29,000 |
0.12% |
|
|
| 21 |
FEDERATION DES CAISSES DESJARDINS DU QUEBEC |
2,732 |
11,826 |
0.05% |
|
|
| 22 |
1832 Asset Management L.P. |
2,500 |
11,000 |
0.05% |
|
|
| 23 |
ROYAL BANK OF CANADA |
610 |
3,000 |
0.01% |
|
|
| 24 |
Tower Research Capital LLC (TRC) |
100 |
1,000 |
0.00% |
|
|
| 25 |
V WEALTH MANAGEMENT,LLC |
100 |
0 |
0.00% |
|
|
| 26 |
TORONTO DOMINION BANK |
12 |
0 |
0.00% |
|
|
