| 1 |
JANUS HENDERSON INVESTORS US LLC |
569,584 |
8,418,000 |
16.42% |
|
|
| 2 |
BAKER BROS. ADVISORS LP |
413,697 |
6,120,000 |
11.94% |
|
|
| 3 |
FRANKLIN RESOURCES INC |
395,000 |
5,838,000 |
11.39% |
|
|
| 4 |
Point72 Asset Management, L.P. |
369,300 |
5,458,000 |
10.65% |
|
|
| 5 |
Avoro Capital Advisors LLC |
316,020 |
4,671,000 |
9.11% |
|
|
| 6 |
EverPoint Asset Management, LLC |
300,000 |
4,434,000 |
8.65% |
|
|
| 7 |
Opaleye Management Inc. |
175,000 |
2,587,000 |
5.05% |
|
|
| 8 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
172,307 |
2,547,000 |
4.97% |
|
|
| 9 |
Private Capital Advisors, Inc. |
146,633 |
2,167,000 |
4.23% |
|
|
| 10 |
SPHERA FUNDS MANAGEMENT LTD. |
132,300 |
1,955,000 |
3.81% |
|
|
| 11 |
Candriam S.C.A. |
110,000 |
1,626,000 |
3.17% |
|
|
| 12 |
PUTNAM INVESTMENTS LLC |
100,000 |
1,478,000 |
2.88% |
|
|
| 13 |
New Leaf Venture Partners, L.L.C. |
80,759 |
1,193,000 |
2.33% |
|
|
| 14 |
Polar Capital LLP |
33,000 |
488,000 |
0.95% |
|
|
| 15 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
25,170 |
372,000 |
0.73% |
|
|
| 16 |
Endurant Capital Management LP |
24,400 |
361,000 |
0.70% |
|
|
| 17 |
FRED ALGER MANAGEMENT, LLC |
23,000 |
340,000 |
0.66% |
|
|
| 18 |
SCHONFELD STRATEGIC ADVISORS LLC |
20,000 |
296,000 |
0.58% |
|
|
| 19 |
MILLENNIUM MANAGEMENT LLC |
17,210 |
254,000 |
0.50% |
|
|
| 20 |
OXFORD ASSET MANAGEMENT LLP |
16,693 |
247,000 |
0.48% |
|
|
| 21 |
WELLS FARGO & COMPANY/MN |
11,800 |
175,000 |
0.34% |
|
|
| 22 |
Creative Planning |
8,100 |
120,000 |
0.23% |
|
|
| 23 |
DEUTSCHE BANK AG\ |
4,577 |
66,000 |
0.13% |
|
|
| 24 |
Tower Research Capital LLC (TRC) |
1,044 |
21,000 |
0.04% |
|
|
| 25 |
SEI INVESTMENTS CO |
500 |
7,000 |
0.01% |
|
|
| 26 |
PRELUDE CAPITAL MANAGEMENT, LLC |
400 |
6,000 |
0.01% |
|
|
| 27 |
MORGAN STANLEY |
400 |
6,000 |
0.01% |
|
|
| 28 |
BANK OF AMERICA CORP /DE/ |
400 |
6,000 |
0.01% |
|
|
| 29 |
ROYAL BANK OF CANADA |
260 |
4,000 |
0.01% |
|
|
| 30 |
UBS Group AG |
200 |
3,000 |
0.01% |
|
|
| 31 |
BANK OF MONTREAL /CAN/ |
49 |
1,000 |
0.00% |
|
|
| 32 |
TORONTO DOMINION BANK |
63 |
1,000 |
0.00% |
|
|
