| 1 |
JANUS HENDERSON INVESTORS US LLC |
566,607 |
5,088,000 |
18.46% |
|
|
| 2 |
FRANKLIN RESOURCES INC |
395,000 |
3,547,000 |
12.87% |
|
|
| 3 |
Point72 Asset Management, L.P. |
369,300 |
3,316,000 |
12.03% |
|
|
| 4 |
Avoro Capital Advisors LLC |
228,697 |
2,054,000 |
7.45% |
|
|
| 5 |
EverPoint Asset Management, LLC |
216,000 |
1,940,000 |
7.04% |
|
|
| 6 |
BAKER BROS. ADVISORS LP |
211,792 |
1,902,000 |
6.90% |
|
|
| 7 |
Opaleye Management Inc. |
195,000 |
1,751,000 |
6.35% |
|
|
| 8 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
172,307 |
1,547,000 |
5.61% |
|
|
| 9 |
SPHERA FUNDS MANAGEMENT LTD. |
132,300 |
1,188,000 |
4.31% |
|
|
| 10 |
MILLENNIUM MANAGEMENT LLC |
114,496 |
1,028,000 |
3.73% |
|
|
| 11 |
Candriam S.C.A. |
110,000 |
969,000 |
3.51% |
|
|
| 12 |
PUTNAM INVESTMENTS LLC |
100,000 |
898,000 |
3.26% |
|
|
| 13 |
OXFORD ASSET MANAGEMENT LLP |
95,267 |
855,000 |
3.10% |
|
|
| 14 |
New Leaf Venture Partners, L.L.C. |
80,759 |
725,000 |
2.63% |
|
|
| 15 |
Endurant Capital Management LP |
27,300 |
245,000 |
0.89% |
|
|
| 16 |
SCHONFELD STRATEGIC ADVISORS LLC |
20,000 |
180,000 |
0.65% |
|
|
| 17 |
K2 PRINCIPAL FUND, L.P. |
14,614 |
131,000 |
0.48% |
|
|
| 18 |
TFS CAPITAL LLC |
11,903 |
107,000 |
0.39% |
|
|
| 19 |
Creative Planning |
5,900 |
53,000 |
0.19% |
|
|
| 20 |
DEUTSCHE BANK AG\ |
2,600 |
22,000 |
0.08% |
|
|
| 21 |
WELLS FARGO & COMPANY/MN |
1,000 |
9,000 |
0.03% |
|
|
| 22 |
SEI INVESTMENTS CO |
500 |
4,000 |
0.01% |
|
|
| 23 |
Tower Research Capital LLC (TRC) |
300 |
3,000 |
0.01% |
|
|
| 24 |
BANK OF MONTREAL /CAN/ |
200 |
2,000 |
0.01% |
|
|
| 25 |
PRELUDE CAPITAL MANAGEMENT, LLC |
200 |
2,000 |
0.01% |
|
|
| 26 |
UBS Group AG |
166 |
1,000 |
0.00% |
|
|
| 27 |
ROYAL BANK OF CANADA |
106 |
1,000 |
0.00% |
|
|
| 28 |
TORONTO DOMINION BANK |
50 |
0 |
0.00% |
|
|
| 29 |
BANK OF AMERICA CORP /DE/ |
2 |
0 |
0.00% |
|
|
