| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JANUS HENDERSON INVESTORS US LLC | 571,203 | 3,227,000 | 21.59% | ||
| 2 | BAKER BROS. ADVISORS LP | 413,697 | 2,337,000 | 15.63% | ||
| 3 | FRANKLIN RESOURCES INC | 395,000 | 2,232,000 | 14.93% | ||
| 4 | Avoro Capital Advisors LLC | 227,399 | 1,285,000 | 8.60% | ||
| 5 | INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 221,847 | 1,253,000 | 8.38% | ||
| 6 | Candriam S.C.A. | 110,000 | 624,000 | 4.17% | ||
| 7 | Opaleye Management Inc. | 110,000 | 622,000 | 4.16% | ||
| 8 | SECTORAL ASSET MANAGEMENT INC | 100,000 | 565,000 | 3.78% | ||
| 9 | New Leaf Venture Partners, L.L.C. | 96,759 | 547,000 | 3.66% | ||
| 10 | PUTNAM INVESTMENTS LLC | 83,111 | 470,000 | 3.14% | ||
| 11 | VICTORY CAPITAL MANAGEMENT INC | 55,430 | 313,000 | 2.09% | ||
| 12 | Creative Planning | 26,100 | 147,000 | 0.98% | ||
| 13 | CREDIT SUISSE AG/ | 25,382 | 143,000 | 0.96% | ||
| 14 | OXFORD ASSET MANAGEMENT LLP | 24,660 | 139,000 | 0.93% | ||
| 15 | PRELUDE CAPITAL MANAGEMENT, LLC | 23,500 | 133,000 | 0.89% | ||
| 16 | Virtu KCG Holdings LLC | 22,470 | 127,000 | 0.85% | ||
| 17 | SCHONFELD STRATEGIC ADVISORS LLC | 22,047 | 125,000 | 0.84% | ||
| 18 | JANE STREET GROUP, LLC | 19,230 | 109,000 | 0.73% | ||
| 19 | K2 PRINCIPAL FUND, L.P. | 16,239 | 92,000 | 0.62% | ||
| 20 | BANK OF AMERICA CORP /DE/ | 15,800 | 89,000 | 0.60% | ||
| 21 | Trexquant Investment LP | 14,902 | 84,000 | 0.56% | ||
| 22 | MILLENNIUM MANAGEMENT LLC | 14,300 | 81,000 | 0.54% | ||
| 23 | WELLS FARGO & COMPANY/MN | 13,200 | 75,000 | 0.50% | ||
| 24 | TFS CAPITAL LLC | 10,247 | 58,000 | 0.39% | ||
| 25 | DEUTSCHE BANK AG\ | 6,100 | 34,000 | 0.23% | ||
| 26 | JPMORGAN CHASE & CO | 4,800 | 27,000 | 0.18% | ||
| 27 | UBS Group AG | 1,277 | 7,000 | 0.05% | ||
| 28 | ROYAL BANK OF CANADA | 577 | 3,000 | 0.02% | ||
| 29 | Tower Research Capital LLC (TRC) | 300 | 2,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
