| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Security, LLC | 2,690,570 | 4,655,000 | 24.30% | ||
| 2 | SOFINNOVA MANAGEMENT VIII, L.L.C. | 2,077,040 | 3,593,000 | 18.76% | ||
| 3 | PERCEPTIVE ADVISORS LLC | 1,777,777 | 3,075,000 | 16.05% | ||
| 4 | FMR LLC | 1,729,620 | 2,992,000 | 15.62% | ||
| 5 | SABBY MANAGEMENT, LLC | 1,095,422 | 1,895,000 | 9.89% | ||
| 6 | Abingworth LLP | 888,889 | 1,476,000 | 7.71% | ||
| 7 | Palo Alto Investors LP | 302,922 | 524,000 | 2.74% | ||
| 8 | VANGUARD GROUP INC | 277,734 | 481,000 | 2.51% | ||
| 9 | CARL DOMINO INC | 89,400 | 155,000 | 0.81% | ||
| 10 | RENAISSANCE TECHNOLOGIES LLC | 70,700 | 122,000 | 0.64% | ||
| 11 | Virtu KCG Holdings LLC | 15,969 | 28,000 | 0.15% | ||
| 12 | Mount Lucas Management LP | 14,000 | 24,000 | 0.13% | ||
| 13 | PURA VIDA INVESTMENTS, LLC | 13,526 | 23,000 | 0.12% | ||
| 14 | CITADEL ADVISORS LLC | 11,568 | 20,000 | 0.10% | ||
| 15 | PANAGORA ASSET MANAGEMENT INC | 11,608 | 20,000 | 0.10% | ||
| 16 | BANK OF AMERICA CORP /DE/ | 11,266 | 19,000 | 0.10% | ||
| 17 | UBS Group AG | 10,798 | 19,000 | 0.10% | ||
| 18 | Creative Planning | 5,000 | 9,000 | 0.05% | ||
| 19 | THOMPSON DAVIS & CO., INC. | 4,500 | 8,000 | 0.04% | ||
| 20 | BlackRock Finance, Inc. | 4,367 | 7,000 | 0.04% | ||
| 21 | ADVISOR GROUP, INC. | 1,300 | 2,000 | 0.01% | ||
| 22 | JBF Capital, Inc. | 1,000 | 2,000 | 0.01% | ||
| 23 | CITIGROUP INC | 1,300 | 2,000 | 0.01% | ||
| 24 | WELLS FARGO & COMPANY/MN | 1,000 | 2,000 | 0.01% | ||
| 25 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 179 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
