| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Security, LLC | 2,690,570 | 8,637,000 | 36.91% | ||
| 2 | PERCEPTIVE ADVISORS LLC | 1,777,777 | 5,706,000 | 24.38% | ||
| 3 | FMR LLC | 1,729,620 | 5,466,000 | 23.36% | ||
| 4 | Palo Alto Investors LP | 454,545 | 1,459,000 | 6.24% | ||
| 5 | ARMISTICE CAPITAL, LLC | 265,355 | 852,000 | 3.64% | ||
| 6 | Abingworth LLP | 176,904 | 543,000 | 2.32% | ||
| 7 | RENAISSANCE TECHNOLOGIES LLC | 65,500 | 210,000 | 0.90% | ||
| 8 | SABBY MANAGEMENT, LLC | 47,823 | 151,000 | 0.65% | ||
| 9 | PURA VIDA INVESTMENTS, LLC | 44,226 | 142,000 | 0.61% | ||
| 10 | CARL DOMINO INC | 34,011 | 110,000 | 0.47% | ||
| 11 | BANK OF AMERICA CORP /DE/ | 12,515 | 40,000 | 0.17% | ||
| 12 | Mount Lucas Management LP | 8,000 | 26,000 | 0.11% | ||
| 13 | PANAGORA ASSET MANAGEMENT INC | 6,434 | 20,000 | 0.09% | ||
| 14 | DEUTSCHE BANK AG\ | 5,600 | 17,000 | 0.07% | ||
| 15 | BlackRock Fund Advisors | 1,949 | 6,000 | 0.03% | ||
| 16 | BLACKROCK ADVISORS LLC | 1,354 | 4,000 | 0.02% | ||
| 17 | BlackRock Japan Co. Ltd | 1,210 | 4,000 | 0.02% | ||
| 18 | CITIGROUP INC | 1,200 | 4,000 | 0.02% | ||
| 19 | Tower Research Capital LLC (TRC) | 470 | 2,000 | 0.01% | ||
| 20 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 179 | 1,000 | 0.00% | ||
| 21 | ROYAL BANK OF CANADA | 61 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
