| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 1,839,969 | 78,383,000 | 8.22% | ||
| 2 | LORD, ABBETT & CO. LLC | 1,413,893 | 60,232,000 | 6.31% | ||
| 3 | FRANKLIN RESOURCES INC | 1,380,086 | 58,792,000 | 6.16% | ||
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,200,000 | 51,120,000 | 5.36% | ||
| 5 | JENNISON ASSOCIATES LLC | 1,167,968 | 49,755,000 | 5.21% | ||
| 6 | EAGLE ASSET MANAGEMENT INC | 1,157,991 | 49,330,000 | 5.17% | ||
| 7 | Callan Capital, LLC | 1,062,313 | 45,255,000 | 4.74% | ||
| 8 | JPMORGAN CHASE & CO | 1,012,355 | 43,125,000 | 4.52% | ||
| 9 | BVF INC/IL | 910,600 | 38,792,000 | 4.07% | ||
| 10 | Tourbillon Capital Partners, L.P. | 875,300 | 37,288,000 | 3.91% | ||
| 11 | Redmile Group, LLC | 753,660 | 32,106,000 | 3.37% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 674,551 | 28,736,000 | 3.01% | ||
| 13 | STATE STREET CORP | 545,672 | 23,247,000 | 2.44% | ||
| 14 | VANGUARD GROUP INC | 495,958 | 21,128,000 | 2.21% | ||
| 15 | Cormorant Asset Management, LP | 478,800 | 20,397,000 | 2.14% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 462,547 | 19,705,000 | 2.07% | ||
| 17 | APEX CAPITAL, LLC | 450,000 | 19,170,000 | 2.01% | ||
| 18 | BlackRock Fund Advisors | 381,096 | 16,235,000 | 1.70% | ||
| 19 | CITADEL ADVISORS LLC | 377,109 | 16,065,000 | 1.68% | ||
| 20 | RS INVESTMENT MANAGEMENT CO LLC | 373,011 | 15,890,000 | 1.67% | ||
| 21 | Polar Capital LLP | 367,411 | 15,652,000 | 1.64% | ||
| 22 | PUTNAM INVESTMENTS LLC | 357,992 | 15,251,000 | 1.60% | ||
| 23 | FARALLON CAPITAL MANAGEMENT LLC | 290,000 | 12,354,000 | 1.29% | ||
| 24 | TUDOR INVESTMENT CORP ET AL | 288,500 | 12,290,000 | 1.29% | ||
| 25 | Visium Asset Management, LP | 276,030 | 11,759,000 | 1.23% | ||
| 26 | MARSHALL WACE, LLP | 219,700 | 9,359,000 | 0.98% | ||
| 27 | BALYASNY ASSET MANAGEMENT L.P. | 216,575 | 9,226,000 | 0.97% | ||
| 28 | PERCEPTIVE ADVISORS LLC | 205,000 | 8,733,000 | 0.92% | ||
| 29 | VOYA INVESTMENT MANAGEMENT LLC | 197,756 | 8,425,000 | 0.88% | ||
| 30 | DRIEHAUS CAPITAL MANAGEMENT LLC | 192,456 | 8,199,000 | 0.86% | ||
| 31 | HIGHLAND CAPITAL MANAGEMENT LP | 137,261 | 5,847,000 | 0.61% | ||
| 32 | BLACKROCK ADVISORS LLC | 125,069 | 5,328,000 | 0.56% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 121,867 | 5,192,000 | 0.54% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 116,558 | 4,965,000 | 0.52% | ||
| 35 | NORTHERN TRUST CORP | 112,859 | 4,808,000 | 0.50% | ||
| 36 | Numeric Investors LLC | 109,694 | 4,673,000 | 0.49% | ||
| 37 | WEXFORD CAPITAL LP | 105,705 | 4,503,000 | 0.47% | ||
| 38 | EverPoint Asset Management, LLC | 105,000 | 4,473,000 | 0.47% | ||
| 39 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 100,433 | 4,279,000 | 0.45% | ||
| 40 | Bank of New York Mellon Corp | 96,315 | 4,103,000 | 0.43% | ||
| 41 | TURNER INVESTMENTS LLC | 85,630 | 3,648,000 | 0.38% | ||
| 42 | Nicholas Investment Partners, LP | 83,993 | 3,578,000 | 0.38% | ||
| 43 | MORGAN STANLEY | 81,565 | 3,475,000 | 0.36% | ||
| 44 | BROWN ADVISORY INC | 78,000 | 3,323,000 | 0.35% | ||
| 45 | Calamos Advisors LLC | 76,122 | 3,243,000 | 0.34% | ||
| 46 | D. E. Shaw & Co., Inc. | 74,840 | 3,188,000 | 0.33% | ||
| 47 | PFM Health Sciences, LP | 72,283 | 3,079,000 | 0.32% | ||
| 48 | MANAGED ACCOUNT ADVISORS LLC | 60,336 | 2,571,000 | 0.27% | ||
| 49 | SPHERA FUNDS MANAGEMENT LTD. | 60,000 | 2,556,000 | 0.27% | ||
| 50 | BlackRock Group LTD | 56,922 | 2,425,000 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
