| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,561,436 | 558,821,000 | 15.17% | ||
| 2 | VANGUARD GROUP INC | 1,218,878 | 149,325,000 | 4.05% | ||
| 3 | JENNISON ASSOCIATES LLC | 1,214,795 | 148,825,000 | 4.04% | ||
| 4 | JPMORGAN CHASE & CO | 1,110,551 | 136,054,000 | 3.69% | ||
| 5 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,006,659 | 123,326,000 | 3.35% | ||
| 6 | BlackRock Fund Advisors | 996,634 | 122,098,000 | 3.32% | ||
| 7 | Callan Capital, LLC | 819,656 | 100,416,000 | 2.73% | ||
| 8 | EAGLE ASSET MANAGEMENT INC | 797,047 | 97,646,000 | 2.65% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 687,159 | 84,184,000 | 2.29% | ||
| 10 | BB BIOTECH AG | 651,181 | 79,776,000 | 2.17% | ||
| 11 | Capital International Investors | 647,400 | 79,313,000 | 2.15% | ||
| 12 | CAPITAL GUARDIAN TRUST CO | 716,900 | 78,981,000 | 2.14% | ||
| 13 | Cormorant Asset Management, LP | 641,800 | 78,627,000 | 2.13% | ||
| 14 | Visium Asset Management, LP | 634,582 | 77,744,000 | 2.11% | ||
| 15 | BLACKROCK ADVISORS LLC | 596,141 | 73,033,000 | 1.98% | ||
| 16 | MILLENNIUM MANAGEMENT LLC | 591,755 | 72,496,000 | 1.97% | ||
| 17 | PRICE T ROWE ASSOCIATES INC /MD/ | 515,173 | 63,114,000 | 1.71% | ||
| 18 | VIKING GLOBAL INVESTORS LP | 511,981 | 62,723,000 | 1.70% | ||
| 19 | FRANKLIN RESOURCES INC | 508,976 | 62,355,000 | 1.69% | ||
| 20 | STATE STREET CORP | 491,770 | 60,251,000 | 1.64% | ||
| 21 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 414,511 | 50,781,742 | 1.38% | ||
| 22 | ALLIANCEBERNSTEIN L.P. | 396,506 | 48,576,000 | 1.32% | ||
| 23 | Tourbillon Capital Partners, L.P. | 385,000 | 47,166,000 | 1.28% | ||
| 24 | PointState Capital LP | 385,000 | 47,166,000 | 1.28% | ||
| 25 | PFM Health Sciences, LP | 363,010 | 44,472,000 | 1.21% | ||
| 26 | LORD, ABBETT & CO. LLC | 342,461 | 41,955,000 | 1.14% | ||
| 27 | BlackRock Group LTD | 316,216 | 38,741,000 | 1.05% | ||
| 28 | Redmile Group, LLC | 312,736 | 38,313,000 | 1.04% | ||
| 29 | PERCEPTIVE ADVISORS LLC | 291,394 | 35,699,000 | 0.97% | ||
| 30 | AMERIPRISE FINANCIAL INC | 266,828 | 32,689,000 | 0.89% | ||
| 31 | PUTNAM INVESTMENTS LLC | 261,351 | 32,018,000 | 0.87% | ||
| 32 | NORTHERN TRUST CORP | 259,471 | 31,788,000 | 0.86% | ||
| 33 | JANUS HENDERSON INVESTORS US LLC | 250,972 | 30,747,000 | 0.83% | ||
| 34 | CADIAN CAPITAL MANAGEMENT, LP | 225,687 | 27,649,000 | 0.75% | ||
| 35 | FEDERATED HERMES, INC. | 212,932 | 26,086,000 | 0.71% | ||
| 36 | RS INVESTMENT MANAGEMENT CO LLC | 211,956 | 25,967,000 | 0.71% | ||
| 37 | DEUTSCHE BANK AG\ | 210,467 | 25,784,000 | 0.70% | ||
| 38 | Polar Capital LLP | 192,623 | 23,598,000 | 0.64% | ||
| 39 | GEODE CAPITAL MANAGEMENT, LLC | 179,783 | 22,025,000 | 0.60% | ||
| 40 | APEX CAPITAL, LLC | 175,200 | 21,464,000 | 0.58% | ||
| 41 | CAPITAL INTERNATIONAL LTD /CA/ | 168,200 | 20,606,000 | 0.56% | ||
| 42 | FARALLON CAPITAL MANAGEMENT LLC | 165,000 | 20,214,000 | 0.55% | ||
| 43 | CITADEL ADVISORS LLC | 159,555 | 19,547,000 | 0.53% | ||
| 44 | ORBIMED ADVISORS LLC | 156,100 | 19,124,000 | 0.52% | ||
| 45 | Bank of New York Mellon Corp | 150,733 | 18,466,000 | 0.50% | ||
| 46 | EcoR1 Capital, LLC | 145,801 | 17,862,000 | 0.48% | ||
| 47 | Capital International Sarl | 139,000 | 17,029,000 | 0.46% | ||
| 48 | Invesco Ltd. | 131,889 | 16,158,000 | 0.44% | ||
| 49 | WELLINGTON MANAGEMENT GROUP LLP | 124,264 | 15,224,000 | 0.41% | ||
| 50 | LOOMIS SAYLES & CO L P | 120,872 | 14,808,000 | 0.40% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
