| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,561,436 | 752,136,000 | 15.65% | ||
| 2 | VANGUARD GROUP INC | 1,658,226 | 273,425,000 | 5.69% | ||
| 3 | Capital International Investors | 1,032,200 | 170,199,000 | 3.54% | ||
| 4 | BlackRock Fund Advisors | 1,020,103 | 168,205,000 | 3.50% | ||
| 5 | VIKING GLOBAL INVESTORS LP | 951,078 | 156,823,000 | 3.26% | ||
| 6 | Callan Capital, LLC | 846,029 | 139,502,000 | 2.90% | ||
| 7 | ING GROEP NV | 820,450 | 135,341,000 | 2.82% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 799,611 | 131,848,000 | 2.74% | ||
| 9 | JPMORGAN CHASE & CO | 784,614 | 129,375,000 | 2.69% | ||
| 10 | BB BIOTECH AG | 635,272 | 104,750,000 | 2.18% | ||
| 11 | CAPITAL GUARDIAN TRUST CO | 635,000 | 104,705,000 | 2.18% | ||
| 12 | PRICE T ROWE ASSOCIATES INC /MD/ | 621,294 | 102,445,000 | 2.13% | ||
| 13 | BLACKROCK ADVISORS LLC | 532,138 | 87,745,000 | 1.83% | ||
| 14 | STATE STREET CORP | 523,432 | 86,304,000 | 1.80% | ||
| 15 | EAGLE ASSET MANAGEMENT INC | 500,420 | 82,514,000 | 1.72% | ||
| 16 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 482,979 | 79,638,000 | 1.66% | ||
| 17 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 459,126 | 75,705,286 | 1.57% | ||
| 18 | JENNISON ASSOCIATES LLC | 440,435 | 72,623,000 | 1.51% | ||
| 19 | FRANKLIN RESOURCES INC | 430,086 | 70,917,000 | 1.48% | ||
| 20 | MILLENNIUM MANAGEMENT LLC | 419,719 | 69,207,000 | 1.44% | ||
| 21 | JANUS HENDERSON INVESTORS US LLC | 418,750 | 69,048,000 | 1.44% | ||
| 22 | ALLIANCEBERNSTEIN L.P. | 394,718 | 65,085,000 | 1.35% | ||
| 23 | Bank of New York Mellon Corp | 391,707 | 64,588,000 | 1.34% | ||
| 24 | Cormorant Asset Management, LP | 390,312 | 64,359,000 | 1.34% | ||
| 25 | Visium Asset Management, LP | 380,207 | 62,692,000 | 1.30% | ||
| 26 | CITADEL ADVISORS LLC | 372,137 | 61,362,000 | 1.28% | ||
| 27 | LORD, ABBETT & CO. LLC | 361,893 | 59,673,000 | 1.24% | ||
| 28 | AMERIPRISE FINANCIAL INC | 340,634 | 56,166,000 | 1.17% | ||
| 29 | NORTHERN TRUST CORP | 262,578 | 43,296,000 | 0.90% | ||
| 30 | GOLDMAN SACHS GROUP INC | 240,881 | 39,719,000 | 0.83% | ||
| 31 | PUTNAM INVESTMENTS LLC | 235,803 | 38,882,000 | 0.81% | ||
| 32 | BlackRock Group LTD | 219,977 | 36,272,000 | 0.75% | ||
| 33 | WELLINGTON MANAGEMENT GROUP LLP | 192,410 | 31,726,000 | 0.66% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 191,231 | 31,532,000 | 0.66% | ||
| 35 | RS INVESTMENT MANAGEMENT CO LLC | 183,891 | 30,322,000 | 0.63% | ||
| 36 | CAPITAL INTERNATIONAL LTD /CA/ | 175,300 | 28,905,000 | 0.60% | ||
| 37 | Redmile Group, LLC | 159,413 | 26,286,000 | 0.55% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 157,238 | 25,927,000 | 0.54% | ||
| 39 | ORBIMED ADVISORS LLC | 156,100 | 25,739,000 | 0.54% | ||
| 40 | EcoR1 Capital, LLC | 151,301 | 24,948,000 | 0.52% | ||
| 41 | Invesco Ltd. | 143,404 | 23,646,000 | 0.49% | ||
| 42 | DEUTSCHE BANK AG\ | 142,099 | 23,429,000 | 0.49% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 134,300 | 22,145,000 | 0.46% | Put | |
| 44 | BARCLAYS PLC | 134,726 | 22,096,000 | 0.46% | ||
| 45 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 129,876 | 21,415,000 | 0.45% | ||
| 46 | COLUMBUS CIRCLE INVESTORS | 128,854 | 21,247,000 | 0.44% | ||
| 47 | Nicholas Investment Partners, LP | 126,804 | 20,909,000 | 0.43% | ||
| 48 | Tekla Capital Management LLC | 124,800 | 20,578,000 | 0.43% | ||
| 49 | Allianz Asset Management GmbH | 123,875 | 20,426,000 | 0.42% | ||
| 50 | PERCEPTIVE ADVISORS LLC | 118,794 | 19,588,000 | 0.41% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
