| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,722,276 | 897,468,000 | 15.82% | ||
| 2 | VANGUARD GROUP INC | 1,722,242 | 327,312,000 | 5.77% | ||
| 3 | VIKING GLOBAL INVESTORS LP | 1,156,900 | 219,869,000 | 3.88% | ||
| 4 | Capital International Investors | 1,032,629 | 196,251,000 | 3.46% | ||
| 5 | Callan Capital, LLC | 841,101 | 159,851,000 | 2.82% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 771,224 | 146,571,000 | 2.58% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 714,226 | 135,739,000 | 2.39% | ||
| 8 | JPMORGAN CHASE & CO | 696,877 | 132,441,000 | 2.34% | ||
| 9 | BB BIOTECH AG | 665,272 | 126,435,000 | 2.23% | ||
| 10 | BlackRock Fund Advisors | 658,811 | 125,207,000 | 2.21% | ||
| 11 | ORBIMED ADVISORS LLC | 628,100 | 119,370,000 | 2.10% | ||
| 12 | CAPITAL GUARDIAN TRUST CO | 608,100 | 115,569,000 | 2.04% | ||
| 13 | CITADEL ADVISORS LLC | 586,003 | 111,370,000 | 1.96% | ||
| 14 | BLACKROCK ADVISORS LLC | 568,873 | 108,114,000 | 1.91% | ||
| 15 | ALLIANCEBERNSTEIN L.P. | 507,539 | 96,458,000 | 1.70% | ||
| 16 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 477,412 | 90,732,151 | 1.60% | ||
| 17 | EAGLE ASSET MANAGEMENT INC | 477,394 | 90,728,000 | 1.60% | ||
| 18 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 467,000 | 88,753,000 | 1.56% | ||
| 19 | STATE STREET CORP | 461,837 | 87,769,000 | 1.55% | ||
| 20 | JANUS HENDERSON INVESTORS US LLC | 460,133 | 87,448,000 | 1.54% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 432,700 | 82,235,000 | 1.45% | Put | |
| 22 | LORD, ABBETT & CO. LLC | 355,562 | 67,575,000 | 1.19% | ||
| 23 | JENNISON ASSOCIATES LLC | 349,997 | 66,517,000 | 1.17% | ||
| 24 | GOLDMAN SACHS GROUP INC | 336,895 | 64,027,000 | 1.13% | ||
| 25 | Bank of New York Mellon Corp | 315,536 | 59,967,000 | 1.06% | ||
| 26 | WELLS FARGO & COMPANY/MN | 311,215 | 59,495,000 | 1.05% | ||
| 27 | Visium Asset Management, LP | 260,090 | 49,430,000 | 0.87% | ||
| 28 | WELLINGTON MANAGEMENT GROUP LLP | 251,370 | 47,772,000 | 0.84% | ||
| 29 | NORTHERN TRUST CORP | 235,788 | 44,811,000 | 0.79% | ||
| 30 | PUTNAM INVESTMENTS LLC | 235,650 | 44,785,000 | 0.79% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 234,500 | 44,567,000 | 0.79% | Call | |
| 32 | Cormorant Asset Management, LP | 220,000 | 41,811,000 | 0.74% | ||
| 33 | NORGES BANK | 211,167 | 40,133,000 | 0.71% | ||
| 34 | BlackRock Group LTD | 187,795 | 35,690,000 | 0.63% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 187,297 | 35,595,000 | 0.63% | ||
| 36 | AMERIPRISE FINANCIAL INC | 184,271 | 35,023,000 | 0.62% | ||
| 37 | Apex Capital Management | 175,802 | 33,411,000 | 0.59% | ||
| 38 | FRANKLIN RESOURCES INC | 174,284 | 33,123,000 | 0.58% | ||
| 39 | RS INVESTMENT MANAGEMENT CO LLC | 170,091 | 32,326,000 | 0.57% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 165,434 | 31,441,000 | 0.55% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 161,834 | 30,756,000 | 0.54% | ||
| 42 | BANK OF MONTREAL /CAN/ | 154,226 | 29,311,000 | 0.52% | ||
| 43 | CAPITAL INTERNATIONAL LTD /CA/ | 152,300 | 28,945,000 | 0.51% | ||
| 44 | BARCLAYS PLC | 151,723 | 28,827,000 | 0.51% | ||
| 45 | BNP Paribas Asset Management Holding S.A. | 150,194 | 28,544,000 | 0.50% | ||
| 46 | Redmile Group, LLC | 144,205 | 27,406,000 | 0.48% | ||
| 47 | DEUTSCHE BANK AG\ | 143,561 | 27,282,000 | 0.48% | ||
| 48 | Invesco Ltd. | 139,372 | 26,487,000 | 0.47% | ||
| 49 | COLUMBUS CIRCLE INVESTORS | 129,653 | 24,641,000 | 0.43% | ||
| 50 | FRED ALGER MANAGEMENT, LLC | 127,698 | 24,269,000 | 0.43% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
