| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,326,969 | 144,528,000 | 9.49% | ||
| 2 | LORD, ABBETT & CO. LLC | 1,333,234 | 82,807,000 | 5.44% | ||
| 3 | BVF INC/IL | 1,146,300 | 71,197,000 | 4.68% | ||
| 4 | EAGLE ASSET MANAGEMENT INC | 1,145,767 | 71,163,000 | 4.67% | ||
| 5 | JENNISON ASSOCIATES LLC | 1,143,184 | 71,003,000 | 4.66% | ||
| 6 | JPMORGAN CHASE & CO | 1,112,817 | 69,115,000 | 4.54% | ||
| 7 | Callan Capital, LLC | 1,100,445 | 68,349,000 | 4.49% | ||
| 8 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 992,605 | 61,651,000 | 4.05% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 866,833 | 53,839,000 | 3.54% | ||
| 10 | Cormorant Asset Management, LP | 748,700 | 46,502,000 | 3.05% | ||
| 11 | FRANKLIN RESOURCES INC | 654,886 | 40,675,000 | 2.67% | ||
| 12 | BB BIOTECH AG | 636,773 | 39,550,000 | 2.60% | ||
| 13 | VANGUARD GROUP INC | 619,213 | 38,459,000 | 2.53% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 551,755 | 34,270,000 | 2.25% | ||
| 15 | STATE STREET CORP | 551,705 | 34,266,000 | 2.25% | ||
| 16 | CITADEL ADVISORS LLC | 469,415 | 29,156,000 | 1.91% | ||
| 17 | BlackRock Fund Advisors | 442,601 | 27,490,000 | 1.81% | ||
| 18 | Redmile Group, LLC | 439,878 | 27,321,000 | 1.79% | ||
| 19 | Tourbillon Capital Partners, L.P. | 417,000 | 25,900,000 | 1.70% | ||
| 20 | PointState Capital LP | 400,000 | 24,844,000 | 1.63% | ||
| 21 | FARALLON CAPITAL MANAGEMENT LLC | 350,000 | 21,739,000 | 1.43% | ||
| 22 | Visium Asset Management, LP | 324,189 | 20,136,000 | 1.32% | ||
| 23 | PERCEPTIVE ADVISORS LLC | 313,594 | 19,477,000 | 1.28% | ||
| 24 | Polar Capital LLP | 288,502 | 17,919,000 | 1.18% | ||
| 25 | CADIAN CAPITAL MANAGEMENT, LP | 266,988 | 16,583,000 | 1.09% | ||
| 26 | RS INVESTMENT MANAGEMENT CO LLC | 262,911 | 16,329,000 | 1.07% | ||
| 27 | PUTNAM INVESTMENTS LLC | 261,441 | 16,238,000 | 1.07% | ||
| 28 | APEX CAPITAL, LLC | 225,000 | 13,975,000 | 0.92% | ||
| 29 | NORTHERN TRUST CORP | 217,494 | 13,509,000 | 0.89% | ||
| 30 | LOOMIS SAYLES & CO L P | 212,862 | 13,221,000 | 0.87% | ||
| 31 | BLACKROCK ADVISORS LLC | 207,358 | 12,879,000 | 0.85% | ||
| 32 | BROWN ADVISORY INC | 197,329 | 12,257,000 | 0.80% | ||
| 33 | EverPoint Asset Management, LLC | 187,000 | 11,615,000 | 0.76% | ||
| 34 | VOYA INVESTMENT MANAGEMENT LLC | 179,256 | 11,134,000 | 0.73% | ||
| 35 | Capital International Investors | 175,700 | 10,913,000 | 0.72% | ||
| 36 | BARCLAYS PLC | 175,000 | 10,850,000 | 0.71% | Call | |
| 37 | ALLIANCEBERNSTEIN L.P. | 172,658 | 10,724,000 | 0.70% | ||
| 38 | CAPITAL GUARDIAN TRUST CO | 168,600 | 10,472,000 | 0.69% | ||
| 39 | MARSHALL WACE, LLP | 156,209 | 9,702,000 | 0.64% | ||
| 40 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 142,898 | 8,875,000 | 0.58% | ||
| 41 | Bank of New York Mellon Corp | 138,380 | 8,595,000 | 0.56% | ||
| 42 | DRIEHAUS CAPITAL MANAGEMENT LLC | 131,397 | 8,161,000 | 0.54% | ||
| 43 | GEODE CAPITAL MANAGEMENT, LLC | 126,978 | 7,886,000 | 0.52% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 124,076 | 7,706,000 | 0.51% | ||
| 45 | TURNER INVESTMENTS LLC | 121,690 | 7,558,000 | 0.50% | ||
| 46 | Tourbillon Capital Partners, L.P. | 110,000 | 6,832,000 | 0.45% | Call | |
| 47 | DIMENSIONAL FUND ADVISORS LP | 106,447 | 6,611,000 | 0.43% | ||
| 48 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 95,700 | 5,944,000 | 0.39% | ||
| 49 | WELLINGTON MANAGEMENT GROUP LLP | 90,683 | 5,632,000 | 0.37% | ||
| 50 | Point72 Asset Management, L.P. | 82,500 | 5,124,000 | 0.34% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
