| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 2,778,654 | 48,071,000 | 12.44% | ||
| 2 | FRANKLIN RESOURCES INC | 2,611,325 | 45,176,000 | 11.69% | ||
| 3 | Visium Asset Management, LP | 1,840,799 | 31,846,000 | 8.24% | ||
| 4 | ORACLE INVESTMENT MANAGEMENT INC | 1,267,126 | 21,921,280 | 5.67% | ||
| 5 | RA CAPITAL MANAGEMENT, L.P. | 1,219,381 | 21,095,000 | 5.46% | ||
| 6 | Sarissa Capital Management LP | 1,003,367 | 17,358,000 | 4.49% | ||
| 7 | FMR LLC | 994,928 | 17,212,000 | 4.45% | ||
| 8 | STATE STREET CORP | 921,128 | 15,937,000 | 4.12% | ||
| 9 | PFM Health Sciences, LP | 850,942 | 14,721,000 | 3.81% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 801,995 | 13,875,000 | 3.59% | ||
| 11 | JANUS HENDERSON INVESTORS US LLC | 790,264 | 13,672,000 | 3.54% | ||
| 12 | FARALLON CAPITAL MANAGEMENT LLC | 700,000 | 12,110,000 | 3.13% | ||
| 13 | VANGUARD GROUP INC | 641,383 | 11,097,000 | 2.87% | ||
| 14 | DESTRIER CAPITAL MANAGEMENT LLC | 633,350 | 10,957,000 | 2.83% | ||
| 15 | BlackRock Fund Advisors | 584,747 | 10,116,000 | 2.62% | ||
| 16 | Lombard Odier Asset Management (USA) Corp | 450,000 | 7,785,000 | 2.01% | ||
| 17 | Invesco Ltd. | 378,408 | 6,547,000 | 1.69% | ||
| 18 | CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 330,000 | 5,709,000 | 1.48% | ||
| 19 | NORTHERN TRUST CORP | 295,771 | 5,118,000 | 1.32% | ||
| 20 | BANK OF AMERICA CORP /DE/ | 238,495 | 4,126,000 | 1.07% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 228,000 | 3,944,000 | 1.02% | Put | |
| 22 | J. Goldman & Co LP | 212,500 | 3,676,000 | 0.95% | Call | |
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 173,600 | 3,003,000 | 0.78% | Call | |
| 24 | GENERAL AMERICAN INVESTORS CO INC | 145,891 | 2,524,000 | 0.65% | ||
| 25 | BARCLAYS PLC | 142,647 | 2,425,000 | 0.63% | ||
| 26 | MORGAN STANLEY | 129,838 | 2,247,000 | 0.58% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 118,347 | 2,047,000 | 0.53% | ||
| 28 | Bank of New York Mellon Corp | 116,796 | 2,020,000 | 0.52% | ||
| 29 | Point72 Asset Management, L.P. | 100,268 | 1,735,000 | 0.45% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 99,829 | 1,727,000 | 0.45% | ||
| 31 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 92,318 | 1,596,000 | 0.41% | ||
| 32 | D. E. Shaw & Co., Inc. | 91,083 | 1,576,000 | 0.41% | ||
| 33 | BARCLAYS PLC | 81,100 | 1,379,000 | 0.36% | Call | |
| 34 | DRIEHAUS CAPITAL MANAGEMENT LLC | 74,035 | 1,281,000 | 0.33% | ||
| 35 | BlackRock Investment Management, LLC | 67,576 | 1,169,000 | 0.30% | ||
| 36 | SABBY MANAGEMENT, LLC | 65,978 | 1,141,000 | 0.30% | ||
| 37 | NOMURA HOLDINGS INC | 65,666 | 1,127,000 | 0.29% | ||
| 38 | BANK OF MONTREAL /CAN/ | 57,200 | 990,000 | 0.26% | Call | |
| 39 | Allianz Asset Management GmbH | 55,911 | 967,000 | 0.25% | ||
| 40 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 54,000 | 934,000 | 0.24% | ||
| 41 | CITIGROUP INC | 52,293 | 904,000 | 0.23% | ||
| 42 | GOLDMAN SACHS GROUP INC | 51,759 | 895,000 | 0.23% | ||
| 43 | Trellus Management Company, LLC | 50,000 | 865,000 | 0.22% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 45,909 | 794,000 | 0.21% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,089 | 728,000 | 0.19% | ||
| 46 | ALLIANCEBERNSTEIN L.P. | 35,900 | 621,000 | 0.16% | ||
| 47 | MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 34,701 | 600,000 | 0.16% | ||
| 48 | BARCLAYS PLC | 34,900 | 593,000 | 0.15% | Put | |
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 32,700 | 566,000 | 0.15% | ||
| 50 | Partner Investment Management, L.P. | 32,535 | 563,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
