| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 2,778,654 | 49,293,000 | 12.47% | ||
| 2 | FRANKLIN RESOURCES INC | 2,351,225 | 41,711,000 | 10.55% | ||
| 3 | Visium Asset Management, LP | 1,840,799 | 32,656,000 | 8.26% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 1,439,048 | 25,529,000 | 6.46% | ||
| 5 | ORACLE INVESTMENT MANAGEMENT INC | 1,242,326 | 22,038,863 | 5.58% | ||
| 6 | PFM Health Sciences, LP | 1,114,462 | 19,771,000 | 5.00% | ||
| 7 | STATE STREET CORP | 1,086,636 | 19,279,000 | 4.88% | ||
| 8 | FMR LLC | 1,028,128 | 18,239,000 | 4.61% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 798,192 | 14,160,000 | 3.58% | ||
| 10 | JANUS HENDERSON INVESTORS US LLC | 791,064 | 14,033,000 | 3.55% | ||
| 11 | FARALLON CAPITAL MANAGEMENT LLC | 700,000 | 12,418,000 | 3.14% | ||
| 12 | BlackRock Fund Advisors | 648,330 | 11,501,000 | 2.91% | ||
| 13 | VANGUARD GROUP INC | 609,134 | 10,806,000 | 2.73% | ||
| 14 | Lombard Odier Asset Management (USA) Corp | 600,000 | 10,644,000 | 2.69% | ||
| 15 | Sarissa Capital Management LP | 560,600 | 9,945,000 | 2.52% | ||
| 16 | DESTRIER CAPITAL MANAGEMENT LLC | 412,726 | 7,322,000 | 1.85% | ||
| 17 | Invesco Ltd. | 371,064 | 6,583,000 | 1.67% | ||
| 18 | NORTHERN TRUST CORP | 319,293 | 5,664,000 | 1.43% | ||
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 253,500 | 4,497,000 | 1.14% | Put | |
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 247,800 | 4,396,000 | 1.11% | Call | |
| 21 | BANK OF AMERICA CORP /DE/ | 201,515 | 3,574,000 | 0.90% | ||
| 22 | QVT Financial LP | 176,417 | 2,964,000 | 0.75% | ||
| 23 | J. Goldman & Co LP | 147,500 | 2,617,000 | 0.66% | Call | |
| 24 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 147,618 | 2,613,000 | 0.66% | ||
| 25 | WEXFORD CAPITAL LP | 140,745 | 2,497,000 | 0.63% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 128,771 | 2,284,000 | 0.58% | ||
| 27 | Bank of New York Mellon Corp | 122,964 | 2,182,000 | 0.55% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 117,255 | 2,080,000 | 0.53% | ||
| 29 | D. E. Shaw & Co., Inc. | 113,310 | 2,010,000 | 0.51% | ||
| 30 | GENERAL AMERICAN INVESTORS CO INC | 102,500 | 1,818,000 | 0.46% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 100,875 | 1,790,000 | 0.45% | ||
| 32 | BARCLAYS PLC | 99,232 | 1,687,000 | 0.43% | ||
| 33 | GOLDMAN SACHS GROUP INC | 89,694 | 1,591,000 | 0.40% | ||
| 34 | DRIEHAUS CAPITAL MANAGEMENT LLC | 76,388 | 1,355,000 | 0.34% | ||
| 35 | BARCLAYS PLC | 74,100 | 1,260,000 | 0.32% | Call | |
| 36 | BANK OF MONTREAL /CAN/ | 67,200 | 1,192,000 | 0.30% | Call | |
| 37 | NOMURA HOLDINGS INC | 65,471 | 1,161,000 | 0.29% | ||
| 38 | BlackRock Investment Management, LLC | 63,692 | 1,130,000 | 0.29% | ||
| 39 | CITIGROUP INC | 59,151 | 1,049,000 | 0.27% | ||
| 40 | Allianz Asset Management GmbH | 56,225 | 997,000 | 0.25% | ||
| 41 | BANK OF MONTREAL /CAN/ | 51,200 | 908,000 | 0.23% | Put | |
| 42 | JANE STREET GROUP, LLC | 50,712 | 900,000 | 0.23% | ||
| 43 | Trellus Management Company, LLC | 50,000 | 887,000 | 0.22% | ||
| 44 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 54,000 | 854,000 | 0.22% | ||
| 45 | Partner Investment Management, L.P. | 44,115 | 783,000 | 0.20% | ||
| 46 | DEUTSCHE BANK AG\ | 43,236 | 766,000 | 0.19% | ||
| 47 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 41,789 | 741,000 | 0.19% | ||
| 48 | ALLIANCEBERNSTEIN L.P. | 35,900 | 637,000 | 0.16% | ||
| 49 | TEACHERS ADVISORS, LLC | 34,192 | 607,000 | 0.15% | ||
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 32,700 | 581,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
