| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,641,425 | 27,056,000 | 23.46% | ||
| 2 | BAKER BROS. ADVISORS LP | 1,955,944 | 14,533,000 | 12.60% | ||
| 3 | Sarissa Capital Management LP | 1,132,367 | 8,413,000 | 7.29% | ||
| 4 | VANGUARD GROUP INC | 762,838 | 5,668,000 | 4.91% | ||
| 5 | MORGAN STANLEY | 724,961 | 5,386,000 | 4.67% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 541,611 | 4,024,000 | 3.49% | ||
| 7 | GENERAL AMERICAN INVESTORS CO INC | 509,060 | 3,782,000 | 3.28% | ||
| 8 | BANK OF AMERICA CORP /DE/ | 379,797 | 2,822,000 | 2.45% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 377,064 | 2,802,000 | 2.43% | ||
| 10 | J. Goldman & Co LP | 350,000 | 2,601,000 | 2.26% | Call | |
| 11 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 348,600 | 2,590,000 | 2.25% | Call | |
| 12 | DESTRIER CAPITAL MANAGEMENT LLC | 329,030 | 2,445,000 | 2.12% | ||
| 13 | Gruss Capital Management LP | 304,000 | 2,259,000 | 1.96% | ||
| 14 | BALYASNY ASSET MANAGEMENT L.P. | 300,000 | 2,229,000 | 1.93% | Call | |
| 15 | HIGHLAND CAPITAL MANAGEMENT LP | 248,318 | 1,845,000 | 1.60% | ||
| 16 | CQS Cayman LP | 240,000 | 1,783,000 | 1.55% | ||
| 17 | RTW INVESTMENTS, LP | 232,830 | 1,730,000 | 1.50% | ||
| 18 | PERCEPTIVE ADVISORS LLC | 220,000 | 1,635,000 | 1.42% | ||
| 19 | C WorldWide Group Holding A/S | 200,000 | 1,486,000 | 1.29% | ||
| 20 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 200,000 | 1,486,000 | 1.29% | Call | |
| 21 | EDMOND DE ROTHSCHILD (SUISSE) S.A. | 185,500 | 1,378,000 | 1.19% | ||
| 22 | EDMOND DE ROTHSCHILD HOLDING S.A. | 185,500 | 1,378,000 | 1.19% | ||
| 23 | GOLDMAN SACHS GROUP INC | 178,715 | 1,328,000 | 1.15% | ||
| 24 | FULLER & THALER ASSET MANAGEMENT, INC. | 168,800 | 1,254,000 | 1.09% | ||
| 25 | ROYCE & ASSOCIATES LP | 129,000 | 958,000 | 0.83% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 128,367 | 953,000 | 0.83% | ||
| 27 | BARCLAYS PLC | 132,013 | 924,000 | 0.80% | ||
| 28 | OXFORD ASSET MANAGEMENT LLP | 122,264 | 908,000 | 0.79% | ||
| 29 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 118,000 | 877,000 | 0.76% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 117,200 | 871,000 | 0.76% | Put | |
| 31 | D. E. Shaw & Co., Inc. | 110,239 | 819,000 | 0.71% | ||
| 32 | NORTHERN TRUST CORP | 108,848 | 809,000 | 0.70% | ||
| 33 | GUGGENHEIM CAPITAL LLC | 98,026 | 728,000 | 0.63% | ||
| 34 | Jefferies Group LLC | 77,700 | 577,000 | 0.50% | Call | |
| 35 | Opus Point Partners Management, LLC | 98,000 | 494,000 | 0.43% | Call | |
| 36 | BlackRock Fund Advisors | 60,239 | 448,000 | 0.39% | ||
| 37 | Bank of New York Mellon Corp | 54,010 | 401,000 | 0.35% | ||
| 38 | RENAISSANCE TECHNOLOGIES LLC | 44,900 | 334,000 | 0.29% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 38,875 | 289,000 | 0.25% | ||
| 40 | BALYASNY ASSET MANAGEMENT L.P. | 35,200 | 262,000 | 0.23% | ||
| 41 | Parallax Volatility Advisers, L.P. | 35,000 | 260,000 | 0.23% | Put | |
| 42 | PDT Partners, LLC | 33,762 | 251,000 | 0.22% | ||
| 43 | Trexquant Investment LP | 33,800 | 251,000 | 0.22% | ||
| 44 | DEUTSCHE BANK AG\ | 33,951 | 251,000 | 0.22% | ||
| 45 | BARCLAYS PLC | 31,900 | 223,000 | 0.19% | Call | |
| 46 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 23,965 | 178,000 | 0.15% | ||
| 47 | GOLDMAN SACHS GROUP INC | 20,600 | 153,000 | 0.13% | Call | |
| 48 | A.R.T. Advisors, LLC | 19,162 | 142,000 | 0.12% | ||
| 49 | SIMPLEX TRADING, LLC | 18,831 | 139,000 | 0.12% | ||
| 50 | STATE STREET CORP | 13,851 | 103,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
