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SYNERGY PHARMACEUTICALS DEL COM NEW
SYNERGY PHARMACEUTICALS DEL COM NEW. Institutional holdings reported to the SEC.

Institutional Holders (2015Q4)
Portfolio Summary: 138 Institutional holders with a total value of $368,544,644.
#
Manager Name
Shares
Value ($)
%
Options
Notes
1 PAULSON & CO. INC. 9,000,000 51,030,000 13.85%
2 VANGUARD GROUP INC 6,587,273 37,350,000 10.13%
3 BlackRock Fund Advisors 5,310,885 30,113,000 8.17%
4 STATE STREET CORP 3,815,852 21,634,000 5.87%
5 MILLENNIUM MANAGEMENT LLC 2,740,786 15,540,000 4.22%
6 BlackRock Institutional Trust Company, N.A. 2,584,484 14,654,000 3.98%
7 CITADEL ADVISORS LLC 2,493,970 14,141,000 3.84%
8 ORBIMED ADVISORS LLC 2,276,648 12,909,000 3.50%
9 Invesco Ltd. 2,128,801 12,071,000 3.28%
10 FRANKLIN RESOURCES INC 2,036,467 11,547,000 3.13%
11 GREAT POINT PARTNERS LLC 1,546,888 8,771,000 2.38%
12 Twin Securities, Inc. 1,445,732 8,197,000 2.22%
13 NORTHERN TRUST CORP 1,118,988 6,345,000 1.72%
14 JPMORGAN CHASE & CO 1,022,095 5,795,000 1.57%
15 Tourbillon Capital Partners, L.P. 980,931 5,562,000 1.51%
16 Allianz Asset Management GmbH 896,296 5,082,000 1.38%
17 CITIGROUP INC 850,207 4,821,000 1.31%
18 Bank of New York Mellon Corp 844,398 4,787,000 1.30%
19 DEUTSCHE BANK AG\ 718,450 4,073,000 1.11%
20 LORD, ABBETT & CO. LLC 714,132 4,049,000 1.10%
21 MOORE CAPITAL MANAGEMENT, LP 665,000 3,771,000 1.02%
22 GEODE CAPITAL MANAGEMENT, LLC 664,407 3,767,000 1.02%
23 Informed Momentum Co LLC 647,686 3,672,000 1.00%
24 Ghost Tree Capital, LLC 600,000 3,402,000 0.92%
25 SUSQUEHANNA INTERNATIONAL GROUP, LLP 504,700 2,862,000 0.78% Put
26 GOLDMAN SACHS GROUP INC 500,000 2,835,000 0.77% Call
27 DRIEHAUS CAPITAL MANAGEMENT LLC 489,127 2,773,000 0.75%
28 MORGAN STANLEY 423,520 2,401,000 0.65%
29 RENAISSANCE TECHNOLOGIES LLC 397,600 2,254,000 0.61%
30 Nicholas Investment Partners, LP 395,059 2,240,000 0.61%
31 PURA VIDA INVESTMENTS, LLC 372,800 2,114,000 0.57%
32 TIAA CREF INVESTMENT MANAGEMENT LLC 352,211 1,997,000 0.54%
33 BlackRock Investment Management, LLC 351,622 1,994,000 0.54%
34 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 342,232 1,941,000 0.53%
35 HIGHBRIDGE CAPITAL MANAGEMENT LLC 338,014 1,916,000 0.52%
36 GOLDMAN SACHS GROUP INC 336,483 1,908,000 0.52%
37 Point72 Asset Management, L.P. 320,400 1,817,000 0.49%
38 AMERIPRISE FINANCIAL INC 312,259 1,770,000 0.48%
39 UBS Group AG 311,998 1,769,000 0.48%
40 ASYMMETRY CAPITAL MANAGEMENT, L.P. 303,157 1,719,000 0.47%
41 DAFNA Capital Management LLC 294,563 1,670,000 0.45%
42 WADDELL & REED FINANCIAL INC 294,300 1,669,000 0.45%
43 WALL STREET ASSOCIATES 269,300 1,527,000 0.41%
44 Cambridge Investment Research Advisors, Inc. 248,289 1,408,000 0.38%
45 SUSQUEHANNA INTERNATIONAL GROUP, LLP 244,421 1,386,000 0.38%
46 KINGDON CAPITAL MANAGEMENT, L.L.C. 229,420 1,301,000 0.35%
47 CREDIT SUISSE AG/ 225,293 1,278,000 0.35%
48 AXA S.A. 220,380 1,250,000 0.34%
49 RUSSELL FRANK CO/ 214,079 1,218,000 0.33%
50 CHESAPEAKE PARTNERS MANAGEMENT CO INC/MD 208,100 1,180,000 0.32%
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From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.