| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PAULSON & CO. INC. | 24,088,655 | 146,700,000 | 20.47% | ||
| 2 | ORBIMED ADVISORS LLC | 18,241,398 | 111,090,000 | 15.50% | ||
| 3 | VANGUARD GROUP INC | 13,292,206 | 80,949,000 | 11.30% | ||
| 4 | BlackRock Fund Advisors | 9,881,438 | 60,178,000 | 8.40% | ||
| 5 | STATE STREET CORP | 6,283,669 | 38,270,000 | 5.34% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 5,026,056 | 30,609,000 | 4.27% | ||
| 7 | GREAT POINT PARTNERS LLC | 4,973,509 | 30,289,000 | 4.23% | ||
| 8 | NORTHERN TRUST CORP | 2,090,773 | 12,733,000 | 1.78% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 1,861,949 | 11,339,000 | 1.58% | ||
| 10 | ARMISTICE CAPITAL, LLC | 1,700,000 | 10,353,000 | 1.44% | ||
| 11 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,568,487 | 9,552,000 | 1.33% | ||
| 12 | Cormorant Asset Management, LP | 1,500,000 | 9,135,000 | 1.27% | ||
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 1,480,953 | 9,018,000 | 1.26% | ||
| 14 | JPMORGAN CHASE & CO | 1,277,775 | 7,782,000 | 1.09% | ||
| 15 | MORGAN STANLEY | 1,212,240 | 7,382,000 | 1.03% | ||
| 16 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,118,822 | 6,814,000 | 0.95% | ||
| 17 | Bank of New York Mellon Corp | 1,109,539 | 6,757,000 | 0.94% | ||
| 18 | GOLDMAN SACHS GROUP INC | 1,013,378 | 6,172,000 | 0.86% | ||
| 19 | GOLDMAN SACHS GROUP INC | 1,000,000 | 6,090,000 | 0.85% | Call | |
| 20 | HighTower Advisors, LLC | 824,949 | 5,022,000 | 0.70% | ||
| 21 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 778,899 | 4,744,000 | 0.66% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 724,455 | 4,412,000 | 0.62% | ||
| 23 | BlackRock Investment Management, LLC | 712,984 | 4,342,000 | 0.61% | ||
| 24 | CITADEL ADVISORS LLC | 587,925 | 3,580,000 | 0.50% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 561,700 | 3,421,000 | 0.48% | Put | |
| 26 | ASYMMETRY CAPITAL MANAGEMENT, L.P. | 555,085 | 3,380,000 | 0.47% | ||
| 27 | PERCEPTIVE ADVISORS LLC | 490,300 | 2,986,000 | 0.42% | ||
| 28 | GROUP ONE TRADING LLC | 456,477 | 2,780,000 | 0.39% | ||
| 29 | Allianz Asset Management GmbH | 446,795 | 2,721,000 | 0.38% | ||
| 30 | CITIGROUP INC | 417,210 | 2,541,000 | 0.35% | ||
| 31 | PALISADE CAPITAL MANAGEMENT, LP | 413,882 | 2,521,000 | 0.35% | ||
| 32 | EverPoint Asset Management, LLC | 400,000 | 2,436,000 | 0.34% | ||
| 33 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 374,144 | 2,279,000 | 0.32% | ||
| 34 | J. Goldman & Co LP | 371,900 | 2,265,000 | 0.32% | ||
| 35 | DRIEHAUS CAPITAL MANAGEMENT LLC | 336,327 | 2,048,000 | 0.29% | ||
| 36 | LORD, ABBETT & CO. LLC | 335,000 | 2,040,000 | 0.28% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 314,000 | 1,912,000 | 0.27% | Call | |
| 38 | INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 312,000 | 1,900,000 | 0.27% | ||
| 39 | TEACHERS ADVISORS, LLC | 298,781 | 1,820,000 | 0.25% | ||
| 40 | Swiss National Bank | 290,850 | 1,771,000 | 0.25% | ||
| 41 | Nationwide Fund Advisors | 276,716 | 1,685,000 | 0.24% | ||
| 42 | ALLIANCEBERNSTEIN L.P. | 269,530 | 1,641,000 | 0.23% | ||
| 43 | CREDIT SUISSE AG/ | 240,918 | 1,467,000 | 0.20% | ||
| 44 | AMERIPRISE FINANCIAL INC | 234,960 | 1,431,000 | 0.20% | ||
| 45 | PRELUDE CAPITAL MANAGEMENT, LLC | 223,436 | 1,361,000 | 0.19% | ||
| 46 | Clear Harbor Asset Management, LLC | 222,760 | 1,357,000 | 0.19% | ||
| 47 | NumerixS Investment Technologies Inc | 217,283 | 1,323,000 | 0.18% | ||
| 48 | D. E. Shaw & Co., Inc. | 216,238 | 1,317,000 | 0.18% | ||
| 49 | RHUMBLINE ADVISERS | 200,076 | 1,218,000 | 0.17% | ||
| 50 | UBS Group AG | 195,293 | 1,189,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
