| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 1,140,325 | 23,274,000 | 25.08% | ||
| 2 | Broadfin Capital, LLC | 878,117 | 13,876,000 | 14.95% | ||
| 3 | FRANKLIN RESOURCES INC | 600,000 | 9,774,000 | 10.53% | ||
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 600,000 | 9,774,000 | 10.53% | ||
| 5 | SPHERA FUNDS MANAGEMENT LTD. | 316,448 | 5,324,000 | 5.74% | ||
| 6 | MILLENNIUM MANAGEMENT LLC | 287,390 | 4,682,000 | 5.05% | ||
| 7 | J. Goldman & Co LP | 283,000 | 4,610,000 | 4.97% | ||
| 8 | Ghost Tree Capital, LLC | 262,696 | 4,279,000 | 4.61% | ||
| 9 | First Light Asset Management, LLC | 258,606 | 4,213,000 | 4.54% | ||
| 10 | PURA VIDA INVESTMENTS, LLC | 194,461 | 3,146,000 | 3.39% | ||
| 11 | ACUTA CAPITAL PARTNERS, LLC | 169,616 | 2,763,000 | 2.98% | ||
| 12 | DAFNA Capital Management LLC | 94,824 | 1,730,000 | 1.86% | ||
| 13 | MONASHEE INVESTMENT MANAGEMENT LLC | 100,000 | 1,629,000 | 1.76% | PRN | |
| 14 | Riverloft Capital Management L.P. | 75,000 | 1,222,000 | 1.32% | ||
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 55,978 | 912,000 | 0.98% | ||
| 16 | CQS Cayman LP | 29,500 | 481,000 | 0.52% | ||
| 17 | SABBY MANAGEMENT, LLC | 19,303 | 314,000 | 0.34% | ||
| 18 | Alyeska Investment Group, L.P. | 15,000 | 244,000 | 0.26% | ||
| 19 | GLG LLC | 14,111 | 230,000 | 0.25% | ||
| 20 | DEUTSCHE BANK AG\ | 9,085 | 147,000 | 0.16% | ||
| 21 | BANK OF MONTREAL /CAN/ | 4,891 | 80,000 | 0.09% | ||
| 22 | UBS Group AG | 2,153 | 35,000 | 0.04% | ||
| 23 | BANK OF AMERICA CORP /DE/ | 2,071 | 34,000 | 0.04% | ||
| 24 | Tower Research Capital LLC (TRC) | 600 | 10,000 | 0.01% | ||
| 25 | TCI Wealth Advisors, Inc. | 500 | 8,000 | 0.01% | ||
| 26 | BARCLAYS PLC | 112 | 2,000 | 0.00% | ||
| 27 | TORONTO DOMINION BANK | 10 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
