| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRANKLIN RESOURCES INC | 1,476,565 | 22,798,000 | 21.33% | ||
| 2 | ORBIMED ADVISORS LLC | 1,140,325 | 17,604,000 | 16.47% | ||
| 3 | Aisling Capital LLC | 1,021,381 | 15,617,000 | 14.61% | ||
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 650,000 | 9,939,000 | 9.30% | ||
| 5 | Broadfin Capital, LLC | 583,121 | 8,916,000 | 8.34% | ||
| 6 | ACUTA CAPITAL PARTNERS, LLC | 376,647 | 5,759,000 | 5.39% | ||
| 7 | First Light Asset Management, LLC | 296,072 | 4,527,000 | 4.23% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 261,702 | 4,001,000 | 3.74% | ||
| 9 | PURA VIDA INVESTMENTS, LLC | 194,461 | 3,013,000 | 2.82% | ||
| 10 | Tekla Capital Management LLC | 180,407 | 2,785,000 | 2.61% | ||
| 11 | Ghost Tree Capital, LLC | 151,630 | 2,318,000 | 2.17% | ||
| 12 | SPHERA FUNDS MANAGEMENT LTD. | 134,037 | 2,070,000 | 1.94% | ||
| 13 | Opaleye Management Inc. | 110,000 | 1,682,000 | 1.57% | ||
| 14 | J. Goldman & Co LP | 108,000 | 1,651,000 | 1.54% | ||
| 15 | CQS Cayman LP | 87,400 | 1,336,000 | 1.25% | ||
| 16 | SABBY MANAGEMENT, LLC | 58,610 | 905,000 | 0.85% | ||
| 17 | GILDER GAGNON HOWE & CO LLC | 48,421 | 740,000 | 0.69% | ||
| 18 | DAFNA Capital Management LLC | 46,629 | 722,000 | 0.68% | ||
| 19 | D. E. Shaw & Co., Inc. | 13,511 | 209,000 | 0.20% | ||
| 20 | Spark Investment Management LLC | 11,200 | 171,000 | 0.16% | ||
| 21 | BANK OF MONTREAL /CAN/ | 4,891 | 75,000 | 0.07% | ||
| 22 | BANK OF AMERICA CORP /DE/ | 1,536 | 23,000 | 0.02% | ||
| 23 | TCI Wealth Advisors, Inc. | 700 | 11,000 | 0.01% | ||
| 24 | Walleye Trading LLC | 600 | 9,000 | 0.01% | ||
| 25 | WELLS FARGO & COMPANY/MN | 500 | 8,000 | 0.01% | ||
| 26 | Creative Planning | 262 | 4,000 | 0.00% | ||
| 27 | BARCLAYS PLC | 100 | 2,000 | 0.00% | ||
| 28 | Tower Research Capital LLC (TRC) | 140 | 2,000 | 0.00% | ||
| 29 | TORONTO DOMINION BANK | 59 | 1,000 | 0.00% | ||
| 30 | MORGAN STANLEY | 21 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
