| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRANKLIN RESOURCES INC | 1,476,565 | 17,571,000 | 20.63% | ||
| 2 | ORBIMED ADVISORS LLC | 1,140,325 | 13,221,000 | 15.52% | ||
| 3 | Aisling Capital LLC | 1,021,381 | 12,154,000 | 14.27% | ||
| 4 | Visium Asset Management, LP | 750,000 | 8,925,000 | 10.48% | ||
| 5 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 650,000 | 7,735,000 | 9.08% | ||
| 6 | ACUTA CAPITAL PARTNERS, LLC | 590,530 | 7,027,000 | 8.25% | ||
| 7 | MILLENNIUM MANAGEMENT LLC | 237,376 | 2,825,000 | 3.32% | ||
| 8 | PURA VIDA INVESTMENTS, LLC | 194,461 | 2,359,000 | 2.77% | ||
| 9 | First Light Asset Management, LLC | 191,980 | 2,285,000 | 2.68% | ||
| 10 | Tekla Capital Management LLC | 180,407 | 2,147,000 | 2.52% | ||
| 11 | Ghost Tree Capital, LLC | 151,535 | 1,803,000 | 2.12% | ||
| 12 | SPHERA FUNDS MANAGEMENT LTD. | 134,037 | 1,595,000 | 1.87% | ||
| 13 | Opaleye Management Inc. | 121,000 | 1,440,000 | 1.69% | ||
| 14 | J. Goldman & Co LP | 73,800 | 878,000 | 1.03% | ||
| 15 | SABBY MANAGEMENT, LLC | 66,522 | 792,000 | 0.93% | ||
| 16 | DAFNA Capital Management LLC | 52,941 | 646,000 | 0.76% | ||
| 17 | GILDER GAGNON HOWE & CO LLC | 49,761 | 592,000 | 0.70% | ||
| 18 | CQS Cayman LP | 40,000 | 476,000 | 0.56% | ||
| 19 | NEXTHERA CAPITAL LP | 33,716 | 401,000 | 0.47% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15,734 | 187,000 | 0.22% | ||
| 21 | BANK OF MONTREAL /CAN/ | 4,891 | 58,000 | 0.07% | ||
| 22 | DEUTSCHE BANK AG\ | 1,000 | 11,000 | 0.01% | ||
| 23 | TCI Wealth Advisors, Inc. | 828 | 10,000 | 0.01% | ||
| 24 | UBS Group AG | 726 | 9,000 | 0.01% | ||
| 25 | WELLS FARGO & COMPANY/MN | 500 | 6,000 | 0.01% | ||
| 26 | Creative Planning | 262 | 3,000 | 0.00% | ||
| 27 | BANK OF AMERICA CORP /DE/ | 250 | 3,000 | 0.00% | ||
| 28 | MORGAN STANLEY | 120 | 1,000 | 0.00% | ||
| 29 | CITIGROUP INC | 17 | 0 | 0.00% | ||
| 30 | TORONTO DOMINION BANK | 24 | 0 | 0.00% | ||
| 31 | D'Orazio & Associates, Inc. | 62 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
