| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 17,459,376 | 320,031,000 | 54.15% | ||
| 2 | ORBIMED ADVISORS LLC | 4,411,186 | 80,857,000 | 13.68% | ||
| 3 | Novo Holdings A/S | 1,761,567 | 32,290,000 | 5.46% | ||
| 4 | Foresite Capital Management II, LLC | 1,757,268 | 32,211,000 | 5.45% | ||
| 5 | Capital World Investors | 1,093,750 | 20,048,000 | 3.39% | ||
| 6 | PFM Health Sciences, LP | 965,515 | 17,698,000 | 2.99% | ||
| 7 | Rock Springs Capital Management LP | 905,000 | 16,589,000 | 2.81% | ||
| 8 | ARROWGRASS CAPITAL PARTNERS (US) LP | 478,854 | 8,777,000 | 1.49% | ||
| 9 | JENNISON ASSOCIATES LLC | 350,000 | 6,416,000 | 1.09% | ||
| 10 | QVT Financial LP | 350,000 | 6,415,000 | 1.09% | ||
| 11 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 300,000 | 5,499,000 | 0.93% | ||
| 12 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 260,100 | 4,768,000 | 0.81% | ||
| 13 | FARALLON CAPITAL MANAGEMENT LLC | 250,000 | 4,583,000 | 0.78% | ||
| 14 | LORD, ABBETT & CO. LLC | 249,533 | 4,574,000 | 0.77% | ||
| 15 | Achievement Holdings L.P. | 228,644 | 4,191,000 | 0.71% | ||
| 16 | Avoro Capital Advisors LLC | 183,900 | 3,371,000 | 0.57% | ||
| 17 | CITADEL ADVISORS LLC | 176,760 | 3,239,000 | 0.55% | ||
| 18 | Alyeska Investment Group, L.P. | 129,853 | 2,380,000 | 0.40% | ||
| 19 | Weiss Multi-Strategy Advisers LLC | 120,000 | 2,200,000 | 0.37% | ||
| 20 | MILLENNIUM MANAGEMENT LLC | 117,817 | 2,160,000 | 0.37% | ||
| 21 | BAKER BROS. ADVISORS LP | 100,000 | 1,833,000 | 0.31% | ||
| 22 | FIL Ltd | 86,849 | 1,592,000 | 0.27% | ||
| 23 | Ghost Tree Capital, LLC | 76,850 | 1,409,000 | 0.24% | ||
| 24 | WALL STREET ASSOCIATES | 60,000 | 1,100,000 | 0.19% | ||
| 25 | PUTNAM INVESTMENTS LLC | 51,481 | 944,000 | 0.16% | ||
| 26 | NORGES BANK | 40,000 | 733,000 | 0.12% | ||
| 27 | ACUTA CAPITAL PARTNERS, LLC | 30,000 | 550,000 | 0.09% | ||
| 28 | FRED ALGER MANAGEMENT, LLC | 28,445 | 521,000 | 0.09% | ||
| 29 | Tekla Capital Management LLC | 27,500 | 504,000 | 0.09% | ||
| 30 | Cormorant Asset Management, LP | 25,000 | 458,000 | 0.08% | ||
| 31 | BlackRock Group LTD | 24,665 | 452,000 | 0.08% | ||
| 32 | State of New Jersey Common Pension Fund D | 24,000 | 440,000 | 0.07% | ||
| 33 | RTW INVESTMENTS, LP | 20,000 | 367,000 | 0.06% | ||
| 34 | Partner Investment Management, L.P. | 18,194 | 333,000 | 0.06% | ||
| 35 | NJ State Employees Deferred Compensation Plan | 16,000 | 293,000 | 0.05% | ||
| 36 | D. E. Shaw & Co., Inc. | 15,232 | 279,000 | 0.05% | ||
| 37 | Virtu KCG Holdings LLC | 14,904 | 273,000 | 0.05% | ||
| 38 | CQS Cayman LP | 12,558 | 231,000 | 0.04% | ||
| 39 | MORGAN STANLEY | 11,517 | 211,000 | 0.04% | ||
| 40 | BlackRock Institutional Trust Company, N.A. | 5,165 | 95,000 | 0.02% | ||
| 41 | UBS Group AG | 2,155 | 40,000 | 0.01% | ||
| 42 | GLENMEDE TRUST CO NA | 1,825 | 33,000 | 0.01% | ||
| 43 | OGOREK ANTHONY JOSEPH /NY/ /ADV | 1,000 | 18,000 | 0.00% | ||
| 44 | BANK OF AMERICA CORP /DE/ | 200 | 4,000 | 0.00% | ||
| 45 | BlackRock Finance, Inc. | 170 | 3,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
