| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 9,880,999 | 69,661,000 | 31.93% | ||
| 2 | FMR LLC | 7,065,180 | 49,809,000 | 22.83% | ||
| 3 | Capital World Investors | 4,601,000 | 32,437,000 | 14.87% | ||
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,157,049 | 8,157,000 | 3.74% | ||
| 5 | BAILLIE GIFFORD & CO | 920,984 | 6,493,000 | 2.98% | ||
| 6 | FIL Ltd | 753,740 | 5,314,000 | 2.44% | ||
| 7 | ORBIMED ADVISORS LLC | 724,184 | 5,105,000 | 2.34% | ||
| 8 | QVT Financial LP | 722,233 | 5,092,000 | 2.33% | ||
| 9 | Rock Springs Capital Management LP | 675,000 | 4,759,000 | 2.18% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 646,490 | 4,558,000 | 2.09% | ||
| 11 | WELLINGTON MANAGEMENT GROUP LLP | 573,723 | 4,045,000 | 1.85% | ||
| 12 | Tekla Capital Management LLC | 566,368 | 3,993,000 | 1.83% | ||
| 13 | PUTNAM INVESTMENTS LLC | 447,181 | 3,153,000 | 1.45% | ||
| 14 | Rathbones Group PLC | 330,125 | 2,327,000 | 1.07% | ||
| 15 | RENAISSANCE TECHNOLOGIES LLC | 328,700 | 2,317,000 | 1.06% | ||
| 16 | Abingworth LLP | 250,000 | 1,763,000 | 0.81% | ||
| 17 | Artal Group S.A. | 200,000 | 1,410,000 | 0.65% | ||
| 18 | Iguana Healthcare Management, LLC | 150,000 | 1,058,000 | 0.48% | ||
| 19 | Zurcher Kantonalbank (Zurich Cantonalbank) | 117,234 | 826,000 | 0.38% | ||
| 20 | BAKER BROS. ADVISORS LP | 100,000 | 705,000 | 0.32% | ||
| 21 | D. E. Shaw & Co., Inc. | 82,307 | 580,000 | 0.27% | ||
| 22 | Vident Investment Advisory, LLC | 73,145 | 516,000 | 0.24% | ||
| 23 | STATE STREET CORP | 65,800 | 464,000 | 0.21% | ||
| 24 | Weiss Multi-Strategy Advisers LLC | 64,000 | 451,000 | 0.21% | ||
| 25 | Polar Capital LLP | 60,000 | 423,000 | 0.19% | ||
| 26 | Compagnie Lombard Odier SCmA | 57,560 | 406,000 | 0.19% | ||
| 27 | New Leaf Venture Partners, L.L.C. | 55,008 | 388,000 | 0.18% | ||
| 28 | ASCEND CAPITAL, LLC | 50,000 | 353,000 | 0.16% | ||
| 29 | Creative Planning | 29,500 | 208,000 | 0.10% | ||
| 30 | VIRTUS ETF ADVISERS LLC | 26,974 | 190,000 | 0.09% | ||
| 31 | Cormorant Asset Management, LP | 25,307 | 178,000 | 0.08% | ||
| 32 | State of New Jersey Common Pension Fund D | 24,000 | 169,000 | 0.08% | ||
| 33 | DEUTSCHE BANK AG\ | 23,349 | 164,000 | 0.08% | ||
| 34 | JPMORGAN CHASE & CO | 21,087 | 149,000 | 0.07% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 16,141 | 113,000 | 0.05% | ||
| 36 | NJ State Employees Deferred Compensation Plan | 16,000 | 112,000 | 0.05% | ||
| 37 | TLP GROUP LLC | 13,311 | 94,000 | 0.04% | ||
| 38 | GSA CAPITAL PARTNERS LLP | 11,803 | 83,000 | 0.04% | ||
| 39 | GLENMEDE TRUST CO NA | 9,998 | 70,000 | 0.03% | ||
| 40 | MORGAN STANLEY | 3,570 | 25,000 | 0.01% | ||
| 41 | UBS Group AG | 3,210 | 23,000 | 0.01% | ||
| 42 | GROUP ONE TRADING LLC | 2,500 | 18,000 | 0.01% | ||
| 43 | Tower Research Capital LLC (TRC) | 1,537 | 11,000 | 0.01% | ||
| 44 | WELLS FARGO & COMPANY/MN | 1,400 | 9,000 | 0.00% | ||
| 45 | OGOREK ANTHONY JOSEPH /NY/ /ADV | 1,000 | 7,000 | 0.00% | ||
| 46 | Advisory Services Network, LLC | 400 | 3,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
