| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 9,880,999 | 40,018,000 | 33.14% | ||
| 2 | FMR LLC | 7,065,180 | 28,614,000 | 23.70% | ||
| 3 | Capital World Investors | 4,480,486 | 18,146,000 | 15.03% | ||
| 4 | BAILLIE GIFFORD & CO | 920,984 | 3,730,000 | 3.09% | ||
| 5 | FIL Ltd | 753,741 | 3,053,000 | 2.53% | ||
| 6 | ORBIMED ADVISORS LLC | 724,184 | 2,933,000 | 2.43% | ||
| 7 | Rock Springs Capital Management LP | 675,000 | 2,734,000 | 2.26% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 671,660 | 2,720,000 | 2.25% | ||
| 9 | QVT Financial LP | 657,258 | 2,662,000 | 2.20% | ||
| 10 | Tekla Capital Management LLC | 566,368 | 2,294,000 | 1.90% | ||
| 11 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 533,901 | 2,162,000 | 1.79% | ||
| 12 | WELLINGTON MANAGEMENT GROUP LLP | 518,523 | 2,100,000 | 1.74% | ||
| 13 | RENAISSANCE TECHNOLOGIES LLC | 445,100 | 1,803,000 | 1.49% | ||
| 14 | Artal Group S.A. | 300,000 | 1,215,000 | 1.01% | ||
| 15 | Abingworth LLP | 250,000 | 1,003,000 | 0.83% | ||
| 16 | Rathbones Group PLC | 200,525 | 812,000 | 0.67% | ||
| 17 | Vident Investment Advisory, LLC | 193,869 | 785,000 | 0.65% | ||
| 18 | Weiss Multi-Strategy Advisers LLC | 110,000 | 446,000 | 0.37% | ||
| 19 | Anson Funds Management LP | 103,282 | 418,000 | 0.35% | ||
| 20 | D. E. Shaw & Co., Inc. | 100,523 | 407,000 | 0.34% | ||
| 21 | Iguana Healthcare Management, LLC | 100,000 | 405,000 | 0.34% | ||
| 22 | BAKER BROS. ADVISORS LP | 100,000 | 405,000 | 0.34% | ||
| 23 | INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 96,419 | 387,000 | 0.32% | ||
| 24 | ALPS ADVISORS INC | 68,024 | 275,000 | 0.23% | ||
| 25 | STATE STREET CORP | 65,800 | 266,000 | 0.22% | ||
| 26 | Compagnie Lombard Odier SCmA | 57,560 | 233,000 | 0.19% | ||
| 27 | JPMORGAN CHASE & CO | 33,843 | 137,000 | 0.11% | ||
| 28 | Creative Planning | 30,500 | 124,000 | 0.10% | ||
| 29 | State of New Jersey Common Pension Fund D | 24,000 | 97,000 | 0.08% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 16,421 | 66,000 | 0.05% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15,941 | 65,000 | 0.05% | ||
| 32 | NJ State Employees Deferred Compensation Plan | 16,000 | 64,000 | 0.05% | ||
| 33 | Zurcher Kantonalbank (Zurich Cantonalbank) | 14,934 | 60,000 | 0.05% | ||
| 34 | WEDBUSH SECURITIES INC | 13,889 | 56,000 | 0.05% | ||
| 35 | GLENMEDE TRUST CO NA | 8,823 | 35,000 | 0.03% | ||
| 36 | OGOREK ANTHONY JOSEPH /NY/ /ADV | 1,000 | 7,000 | 0.01% | ||
| 37 | WELLS FARGO & COMPANY/MN | 1,400 | 6,000 | 0.00% | ||
| 38 | UBS Group AG | 774 | 3,000 | 0.00% | ||
| 39 | ACROSPIRE INVESTMENT MANAGEMENT LLC | 400 | 2,000 | 0.00% | ||
| 40 | Tower Research Capital LLC (TRC) | 288 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
