| 1 |
FMR LLC |
6,592,301 |
79,503,000 |
31.79% |
|
|
| 2 |
Capital World Investors |
4,601,000 |
55,488,000 |
22.19% |
|
|
| 3 |
Foresite Capital Management II, LLC |
1,761,567 |
21,244,000 |
8.50% |
|
|
| 4 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
850,000 |
10,251,000 |
4.10% |
|
|
| 5 |
Rock Springs Capital Management LP |
765,001 |
9,226,000 |
3.69% |
|
|
| 6 |
FIL Ltd |
753,740 |
9,090,000 |
3.64% |
|
|
| 7 |
QVT Financial LP |
665,566 |
8,027,000 |
3.21% |
|
|
| 8 |
WELLINGTON MANAGEMENT GROUP LLP |
580,173 |
6,997,000 |
2.80% |
|
|
| 9 |
JENNISON ASSOCIATES LLC |
486,948 |
5,873,000 |
2.35% |
|
|
| 10 |
ORBIMED ADVISORS LLC |
438,784 |
5,292,000 |
2.12% |
|
|
| 11 |
Iguana Healthcare Management, LLC |
353,161 |
4,259,000 |
1.70% |
|
|
| 12 |
MILLENNIUM MANAGEMENT LLC |
344,547 |
4,155,000 |
1.66% |
|
|
| 13 |
EverPoint Asset Management, LLC |
325,000 |
3,920,000 |
1.57% |
|
|
| 14 |
Tekla Capital Management LLC |
296,934 |
3,581,000 |
1.43% |
|
|
| 15 |
Abingworth LLP |
250,000 |
3,013,000 |
1.20% |
|
|
| 16 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
211,555 |
2,551,000 |
1.02% |
|
|
| 17 |
Ghost Tree Capital, LLC |
210,000 |
2,533,000 |
1.01% |
|
|
| 18 |
MARSHALL WACE, LLP |
140,983 |
1,700,000 |
0.68% |
|
|
| 19 |
Point72 Asset Management, L.P. |
130,200 |
1,570,000 |
0.63% |
|
|
| 20 |
Rathbones Group PLC |
200,525 |
1,514,000 |
0.61% |
|
|
| 21 |
Weiss Multi-Strategy Advisers LLC |
103,000 |
1,242,000 |
0.50% |
|
|
| 22 |
BAKER BROS. ADVISORS LP |
100,000 |
1,206,000 |
0.48% |
|
|
| 23 |
Vident Investment Advisory, LLC |
75,540 |
911,000 |
0.36% |
|
|
| 24 |
STATE STREET CORP |
65,800 |
794,000 |
0.32% |
|
|
| 25 |
RS INVESTMENT MANAGEMENT CO LLC |
62,980 |
760,000 |
0.30% |
|
|
| 26 |
FRED ALGER MANAGEMENT, LLC |
58,195 |
702,000 |
0.28% |
|
|
| 27 |
PUTNAM INVESTMENTS LLC |
51,481 |
621,000 |
0.25% |
|
|
| 28 |
GRATICULE ASIA MACRO ADVISORS LLC |
50,000 |
603,000 |
0.24% |
|
|
| 29 |
DAFNA Capital Management LLC |
48,100 |
580,000 |
0.23% |
|
|
| 30 |
Anson Funds Management LP |
30,737 |
371,000 |
0.15% |
|
|
| 31 |
RENAISSANCE TECHNOLOGIES LLC |
29,300 |
353,000 |
0.14% |
|
|
| 32 |
Quantitative Systematic Strategies LLC |
24,918 |
303,000 |
0.12% |
|
|
| 33 |
Cormorant Asset Management, LP |
25,000 |
302,000 |
0.12% |
|
|
| 34 |
State of New Jersey Common Pension Fund D |
24,000 |
289,000 |
0.12% |
|
|
| 35 |
Creative Planning |
22,550 |
272,000 |
0.11% |
|
|
| 36 |
A.R.T. Advisors, LLC |
22,000 |
265,000 |
0.11% |
|
|
| 37 |
NJ State Employees Deferred Compensation Plan |
16,000 |
193,000 |
0.08% |
|
|
| 38 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
10,844 |
131,000 |
0.05% |
|
|
| 39 |
Compagnie Lombard Odier SCmA |
7,560 |
91,000 |
0.04% |
|
|
| 40 |
RTW INVESTMENTS, LP |
6,923 |
83,000 |
0.03% |
|
|
| 41 |
UBS Group AG |
5,164 |
62,000 |
0.02% |
|
|
| 42 |
MORGAN STANLEY |
5,188 |
62,000 |
0.02% |
|
|
| 43 |
GLENMEDE TRUST CO NA |
3,100 |
37,000 |
0.01% |
|
|
| 44 |
OGOREK ANTHONY JOSEPH /NY/ /ADV |
1,000 |
12,000 |
0.00% |
|
|
| 45 |
D.A. DAVIDSON & CO. |
1,000 |
12,000 |
0.00% |
|
|
| 46 |
WELLS FARGO & COMPANY/MN |
600 |
7,000 |
0.00% |
|
|
| 47 |
BlackRock Finance, Inc. |
600 |
7,000 |
0.00% |
|
|
| 48 |
DEUTSCHE BANK AG\ |
500 |
6,000 |
0.00% |
|
|
| 49 |
Cubist Systematic Strategies, LLC |
7 |
0 |
0.00% |
|
|
