| 1 |
FMR LLC |
2,009,300 |
19,149,000 |
25.53% |
|
|
| 2 |
WELLINGTON MANAGEMENT GROUP LLP |
1,870,480 |
17,825,000 |
23.77% |
|
|
| 3 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,327,009 |
12,646,000 |
16.86% |
|
|
| 4 |
Novo Holdings A/S |
1,075,448 |
10,249,000 |
13.67% |
|
|
| 5 |
WALL STREET ASSOCIATES |
309,000 |
2,945,000 |
3.93% |
|
|
| 6 |
RTW INVESTMENTS, LP |
226,042 |
2,154,000 |
2.87% |
|
|
| 7 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
219,150 |
2,088,000 |
2.78% |
|
|
| 8 |
AWM Investment Company, Inc. |
150,000 |
1,429,000 |
1.91% |
|
|
| 9 |
VANGUARD GROUP INC |
115,244 |
1,098,000 |
1.46% |
|
|
| 10 |
WEXFORD CAPITAL LP |
97,667 |
931,000 |
1.24% |
|
|
| 11 |
Fiera Capital Corp |
72,131 |
687,000 |
0.92% |
|
|
| 12 |
Mitsubishi UFJ Asset Management Co., Ltd. |
65,000 |
619,000 |
0.83% |
|
|
| 13 |
Cowen Prime Services LLC |
61,000 |
581,000 |
0.77% |
|
|
| 14 |
Coe Capital Management, LLC |
57,974 |
552,493 |
0.74% |
|
|
| 15 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
40,000 |
381,000 |
0.51% |
|
|
| 16 |
Cormorant Asset Management, LP |
34,200 |
326,000 |
0.43% |
|
|
| 17 |
BlackRock Fund Advisors |
25,100 |
239,000 |
0.32% |
|
|
| 18 |
GEODE CAPITAL MANAGEMENT, LLC |
23,945 |
228,000 |
0.30% |
|
|
| 19 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
20,938 |
200,000 |
0.27% |
|
|
| 20 |
Paloma Partners Management Co |
18,835 |
179,000 |
0.24% |
|
|
| 21 |
MILLENNIUM MANAGEMENT LLC |
16,612 |
158,000 |
0.21% |
|
|
| 22 |
BANK OF AMERICA CORP /DE/ |
12,603 |
120,000 |
0.16% |
|
|
| 23 |
DEUTSCHE BANK AG\ |
8,762 |
82,000 |
0.11% |
|
|
| 24 |
WELLS FARGO & COMPANY/MN |
2,800 |
27,000 |
0.04% |
|
|
| 25 |
NEW YORK STATE COMMON RETIREMENT FUND |
2,100 |
20,000 |
0.03% |
|
|
| 26 |
Stanford Investment Group, Inc. |
2,000 |
19,000 |
0.03% |
|
|
| 27 |
MORGAN STANLEY |
1,801 |
17,000 |
0.02% |
|
|
| 28 |
BlackRock Investment Management, LLC |
1,814 |
17,000 |
0.02% |
|
|
| 29 |
Tower Research Capital LLC (TRC) |
1,332 |
13,000 |
0.02% |
|
|
| 30 |
MSI Financial Services Inc |
700 |
7,000 |
0.01% |
|
|
| 31 |
Plante Moran Financial Advisors, LLC |
500 |
5,000 |
0.01% |
|
|
| 32 |
BARCLAYS PLC |
432 |
4,000 |
0.01% |
|
|
