| 1 |
FMR LLC |
2,191,500 |
30,067,000 |
19.99% |
|
|
| 2 |
WELLINGTON MANAGEMENT GROUP LLP |
1,610,228 |
22,092,000 |
14.69% |
|
|
| 3 |
Novo Holdings A/S |
1,285,448 |
17,636,000 |
11.73% |
|
|
| 4 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,282,598 |
17,597,000 |
11.70% |
|
|
| 5 |
Cormorant Asset Management, LP |
767,466 |
10,530,000 |
7.00% |
|
|
| 6 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
464,150 |
6,368,000 |
4.23% |
|
|
| 7 |
VANGUARD GROUP INC |
446,555 |
6,126,000 |
4.07% |
|
|
| 8 |
RTW INVESTMENTS, LP |
392,838 |
5,390,000 |
3.58% |
|
|
| 9 |
NEXT CENTURY GROWTH INVESTORS LLC |
332,922 |
4,567,000 |
3.04% |
|
|
| 10 |
WALL STREET ASSOCIATES |
331,700 |
4,551,000 |
3.03% |
|
|
| 11 |
Venator Capital Management Ltd. |
275,521 |
3,780,000 |
2.51% |
|
|
| 12 |
Cowen Prime Services LLC |
257,950 |
3,539,000 |
2.35% |
|
|
| 13 |
Allianz Asset Management GmbH |
196,897 |
2,701,000 |
1.80% |
|
|
| 14 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
161,853 |
2,221,000 |
1.48% |
|
|
| 15 |
AWM Investment Company, Inc. |
150,000 |
2,058,000 |
1.37% |
|
|
| 16 |
Iguana Healthcare Management, LLC |
100,000 |
1,372,000 |
0.91% |
|
|
| 17 |
WEXFORD CAPITAL LP |
97,667 |
1,340,000 |
0.89% |
|
|
| 18 |
Coe Capital Management, LLC |
102,369 |
1,039,045 |
0.69% |
|
|
| 19 |
Fiera Capital Corp |
72,131 |
990,000 |
0.66% |
|
|
| 20 |
GEODE CAPITAL MANAGEMENT, LLC |
71,235 |
977,000 |
0.65% |
|
|
| 21 |
AXIOM INVESTORS LLC /DE |
61,654 |
846,000 |
0.56% |
|
|
| 22 |
Mitsubishi UFJ Asset Management Co., Ltd. |
60,000 |
823,000 |
0.55% |
|
|
| 23 |
NORTHERN TRUST CORP |
41,356 |
567,000 |
0.38% |
|
|
| 24 |
BlackRock Fund Advisors |
30,731 |
422,000 |
0.28% |
|
|
| 25 |
Spark Investment Management LLC |
23,613 |
323,000 |
0.21% |
|
|
| 26 |
MILLENNIUM MANAGEMENT LLC |
23,295 |
320,000 |
0.21% |
|
|
| 27 |
RENAISSANCE TECHNOLOGIES LLC |
23,100 |
317,000 |
0.21% |
|
|
| 28 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
20,888 |
287,000 |
0.19% |
|
|
| 29 |
WHITE PINE CAPITAL LLC |
18,500 |
254,000 |
0.17% |
|
|
| 30 |
Integre Asset Management, LLC |
18,431 |
253,000 |
0.17% |
|
|
| 31 |
TWO SIGMA INVESTMENTS, LP |
14,980 |
206,000 |
0.14% |
|
|
| 32 |
Manatuck Hill Partners, LLC |
15,000 |
206,000 |
0.14% |
|
|
| 33 |
GOLDMAN SACHS GROUP INC |
13,774 |
189,000 |
0.13% |
|
|
| 34 |
BANK OF AMERICA CORP /DE/ |
11,113 |
152,000 |
0.10% |
|
|
| 35 |
DEUTSCHE BANK AG\ |
7,334 |
100,000 |
0.07% |
|
|
| 36 |
WELLS FARGO & COMPANY/MN |
2,800 |
38,000 |
0.03% |
|
|
| 37 |
BlackRock Investment Management, LLC |
2,222 |
30,000 |
0.02% |
|
|
| 38 |
UBS Group AG |
2,215 |
30,000 |
0.02% |
|
|
| 39 |
Stanford Investment Group, Inc. |
2,000 |
27,000 |
0.02% |
|
|
| 40 |
MORGAN STANLEY |
850 |
12,000 |
0.01% |
|
|
| 41 |
MSI Financial Services Inc |
700 |
10,000 |
0.01% |
|
|
| 42 |
SEI INVESTMENTS CO |
501 |
7,000 |
0.00% |
|
|
| 43 |
Plante Moran Financial Advisors, LLC |
500 |
7,000 |
0.00% |
|
|
| 44 |
Carroll Financial Associates, Inc. |
500 |
6,000 |
0.00% |
|
|
