| 1 |
WELLINGTON MANAGEMENT GROUP LLP |
1,876,490 |
16,551,000 |
23.55% |
|
|
| 2 |
FMR LLC |
1,657,800 |
14,622,000 |
20.80% |
|
|
| 3 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,078,218 |
9,510,000 |
13.53% |
|
|
| 4 |
Novo Holdings A/S |
925,000 |
8,158,000 |
11.61% |
|
|
| 5 |
WEXFORD CAPITAL LP |
504,613 |
4,451,000 |
6.33% |
|
|
| 6 |
WALL STREET ASSOCIATES |
309,000 |
2,725,000 |
3.88% |
|
|
| 7 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
302,650 |
2,669,000 |
3.80% |
|
|
| 8 |
NORTHPOINTE CAPITAL LLC |
135,960 |
1,906,000 |
2.71% |
|
|
| 9 |
Napier Park Global Capital (US) LP |
210,900 |
1,860,000 |
2.65% |
|
|
| 10 |
RTW INVESTMENTS, LP |
202,808 |
1,789,000 |
2.55% |
|
|
| 11 |
AWM Investment Company, Inc. |
160,000 |
1,411,000 |
2.01% |
|
|
| 12 |
BlackRock Fund Advisors |
125,864 |
1,110,000 |
1.58% |
|
|
| 13 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
75,000 |
662,000 |
0.94% |
|
|
| 14 |
VANGUARD GROUP INC |
62,403 |
550,000 |
0.78% |
|
|
| 15 |
NORTHERN TRUST CORP |
43,039 |
379,000 |
0.54% |
|
|
| 16 |
STATE STREET CORP |
34,416 |
304,000 |
0.43% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
25,954 |
228,000 |
0.32% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
23,682 |
209,000 |
0.30% |
|
|
| 19 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
21,528 |
190,000 |
0.27% |
|
|
| 20 |
Spark Investment Management LLC |
14,100 |
124,000 |
0.18% |
|
|
| 21 |
RENAISSANCE TECHNOLOGIES LLC |
12,800 |
113,000 |
0.16% |
|
|
| 22 |
TWO SIGMA INVESTMENTS, LP |
12,760 |
113,000 |
0.16% |
|
|
| 23 |
Bank of New York Mellon Corp |
10,896 |
96,000 |
0.14% |
|
|
| 24 |
BlackRock Investment Management, LLC |
10,473 |
92,000 |
0.13% |
|
|
| 25 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
8,500 |
75,000 |
0.11% |
|
|
| 26 |
DEUTSCHE BANK AG\ |
8,751 |
75,000 |
0.11% |
|
|
| 27 |
NEW YORK STATE COMMON RETIREMENT FUND |
7,000 |
62,000 |
0.09% |
|
|
| 28 |
TEACHERS ADVISORS, LLC |
4,632 |
41,000 |
0.06% |
|
|
| 29 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
4,264 |
38,000 |
0.05% |
|
|
| 30 |
BANK OF AMERICA CORP /DE/ |
4,216 |
37,000 |
0.05% |
|
|
| 31 |
Nationwide Fund Advisors |
2,649 |
23,000 |
0.03% |
|
|
| 32 |
MORGAN STANLEY |
2,456 |
22,000 |
0.03% |
|
|
| 33 |
WHITTIER TRUST CO |
42,993 |
20,000 |
0.03% |
|
|
| 34 |
Tower Research Capital LLC (TRC) |
1,788 |
15,000 |
0.02% |
|
|
| 35 |
BLACKROCK ADVISORS LLC |
1,565 |
14,000 |
0.02% |
|
|
| 36 |
STRS OHIO |
1,500 |
13,000 |
0.02% |
|
|
| 37 |
CITIGROUP INC |
1,389 |
12,000 |
0.02% |
|
|
| 38 |
WELLS FARGO & COMPANY/MN |
809 |
7,000 |
0.01% |
|
|
| 39 |
MSI Financial Services Inc |
700 |
6,000 |
0.01% |
|
|
| 40 |
BNP PARIBAS FINANCIAL MARKETS |
428 |
3,775 |
0.01% |
|
|
