| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,690,498 | 9,720,000 | 13.97% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 1,550,351 | 8,914,000 | 12.81% | ||
| 3 | Novo Holdings A/S | 1,318,448 | 7,581,000 | 10.89% | ||
| 4 | INTERWEST VENTURE MANAGEMENT CO | 1,080,272 | 6,212,000 | 8.93% | ||
| 5 | FMR LLC | 825,300 | 4,745,000 | 6.82% | ||
| 6 | Cormorant Asset Management, LP | 767,466 | 4,413,000 | 6.34% | ||
| 7 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 723,432 | 4,160,000 | 5.98% | ||
| 8 | RTW INVESTMENTS, LP | 454,900 | 2,616,000 | 3.76% | ||
| 9 | Lyon Street Capital, LLC | 394,439 | 2,268,000 | 3.26% | ||
| 10 | WELL DONE, LLC | 367,087 | 2,111,000 | 3.03% | ||
| 11 | VANGUARD GROUP INC | 344,632 | 1,981,000 | 2.85% | ||
| 12 | NEEDHAM INVESTMENT MANAGEMENT LLC | 320,139 | 1,841,000 | 2.65% | ||
| 13 | Cowen Prime Services LLC | 309,250 | 1,778,000 | 2.55% | ||
| 14 | DIALECTIC CAPITAL MANAGEMENT, LP | 235,000 | 1,351,000 | 1.94% | ||
| 15 | PFM Health Sciences, LP | 231,329 | 1,330,000 | 1.91% | ||
| 16 | Alyeska Investment Group, L.P. | 148,800 | 856,000 | 1.23% | ||
| 17 | Granite Investment Partners, LLC | 144,596 | 831,000 | 1.19% | ||
| 18 | Mitsubishi UFJ Asset Management Co., Ltd. | 116,700 | 671,000 | 0.96% | ||
| 19 | INTRINSIC EDGE CAPITAL MANAGEMENT LLC | 102,369 | 589,000 | 0.85% | ||
| 20 | DISCOVERY GROUP I, LLC | 102,290 | 588,000 | 0.84% | ||
| 21 | WEXFORD CAPITAL LP | 97,667 | 562,000 | 0.81% | ||
| 22 | AWM Investment Company, Inc. | 84,222 | 484,000 | 0.70% | ||
| 23 | WALL STREET ASSOCIATES | 75,001 | 431,000 | 0.62% | ||
| 24 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 75,000 | 431,000 | 0.62% | ||
| 25 | Fiera Capital Corp | 72,131 | 415,000 | 0.60% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 71,403 | 410,000 | 0.59% | ||
| 27 | AXIOM INVESTORS LLC /DE | 61,804 | 355,000 | 0.51% | ||
| 28 | Invesco Ltd. | 55,264 | 318,000 | 0.46% | ||
| 29 | Trexquant Investment LP | 31,914 | 184,000 | 0.26% | ||
| 30 | BlackRock Fund Advisors | 31,035 | 178,000 | 0.26% | ||
| 31 | CITADEL ADVISORS LLC | 27,267 | 157,000 | 0.23% | ||
| 32 | NORTHERN TRUST CORP | 27,125 | 156,000 | 0.22% | ||
| 33 | Integre Asset Management, LLC | 26,469 | 152,000 | 0.22% | ||
| 34 | ROYCE & ASSOCIATES LP | 22,180 | 128,000 | 0.18% | ||
| 35 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 21,418 | 123,000 | 0.18% | ||
| 36 | Dynamic Technology Lab Private Ltd | 15,135 | 87,000 | 0.13% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 14,246 | 82,000 | 0.12% | ||
| 38 | Bank of New York Mellon Corp | 12,759 | 73,000 | 0.10% | ||
| 39 | MILLENNIUM MANAGEMENT LLC | 12,479 | 72,000 | 0.10% | ||
| 40 | UBS Group AG | 8,606 | 49,000 | 0.07% | ||
| 41 | DEUTSCHE BANK AG\ | 7,964 | 45,000 | 0.06% | ||
| 42 | WELLS FARGO & COMPANY/MN | 6,200 | 36,000 | 0.05% | ||
| 43 | Tower Research Capital LLC (TRC) | 5,072 | 29,000 | 0.04% | ||
| 44 | Stanford Investment Group, Inc. | 3,700 | 21,000 | 0.03% | ||
| 45 | MORGAN STANLEY | 2,488 | 14,000 | 0.02% | ||
| 46 | BlackRock Investment Management, LLC | 2,222 | 13,000 | 0.02% | ||
| 47 | MCF Advisors LLC | 1,815 | 10,000 | 0.01% | ||
| 48 | PRELUDE CAPITAL MANAGEMENT, LLC | 1,713 | 10,000 | 0.01% | ||
| 49 | MSI Financial Services Inc | 700 | 4,000 | 0.01% | ||
| 50 | SEI INVESTMENTS CO | 759 | 4,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
