| 1 |
WELLINGTON MANAGEMENT GROUP LLP |
1,866,950 |
13,480,000 |
23.23% |
|
|
| 2 |
FMR LLC |
1,733,100 |
12,513,000 |
21.56% |
|
|
| 3 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,327,009 |
9,581,000 |
16.51% |
|
|
| 4 |
Novo Holdings A/S |
936,193 |
6,759,000 |
11.65% |
|
|
| 5 |
WALL STREET ASSOCIATES |
309,000 |
2,231,000 |
3.84% |
|
|
| 6 |
WEXFORD CAPITAL LP |
306,481 |
2,213,000 |
3.81% |
|
|
| 7 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
244,150 |
1,763,000 |
3.04% |
|
|
| 8 |
RTW INVESTMENTS, LP |
212,808 |
1,536,000 |
2.65% |
|
|
| 9 |
Napier Park Global Capital (US) LP |
210,900 |
1,523,000 |
2.62% |
|
|
| 10 |
AWM Investment Company, Inc. |
160,000 |
1,155,000 |
1.99% |
|
|
| 11 |
Granite Investment Partners, LLC |
119,967 |
866,000 |
1.49% |
|
|
| 12 |
BlackRock Fund Advisors |
119,282 |
861,000 |
1.48% |
|
|
| 13 |
VANGUARD GROUP INC |
110,103 |
795,000 |
1.37% |
|
|
| 14 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
75,000 |
542,000 |
0.93% |
|
|
| 15 |
Mitsubishi UFJ Asset Management Co., Ltd. |
65,000 |
469,000 |
0.81% |
|
|
| 16 |
NORTHERN TRUST CORP |
43,039 |
311,000 |
0.54% |
|
|
| 17 |
STATE STREET CORP |
36,116 |
259,000 |
0.45% |
|
|
| 18 |
GEODE CAPITAL MANAGEMENT, LLC |
25,912 |
187,000 |
0.32% |
|
|
| 19 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
21,528 |
155,000 |
0.27% |
|
|
| 20 |
BlackRock Institutional Trust Company, N.A. |
21,142 |
153,000 |
0.26% |
|
|
| 21 |
GOLDMAN SACHS GROUP INC |
13,919 |
100,000 |
0.17% |
|
|
| 22 |
BANK OF AMERICA CORP /DE/ |
12,257 |
88,000 |
0.15% |
|
|
| 23 |
Bank of New York Mellon Corp |
10,896 |
79,000 |
0.14% |
|
|
| 24 |
BlackRock Investment Management, LLC |
10,717 |
77,000 |
0.13% |
|
|
| 25 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
9,737 |
70,000 |
0.12% |
|
|
| 26 |
NEW YORK STATE COMMON RETIREMENT FUND |
7,000 |
51,000 |
0.09% |
|
|
| 27 |
TEACHERS ADVISORS, LLC |
4,632 |
33,000 |
0.06% |
|
|
| 28 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
4,264 |
31,000 |
0.05% |
|
|
| 29 |
DEUTSCHE BANK AG\ |
4,183 |
29,000 |
0.05% |
|
|
| 30 |
CITIGROUP INC |
3,259 |
24,000 |
0.04% |
|
|
| 31 |
Nationwide Fund Advisors |
2,649 |
19,000 |
0.03% |
|
|
| 32 |
AMERICAN INTERNATIONAL GROUP, INC. |
2,623 |
19,000 |
0.03% |
|
|
| 33 |
Tower Research Capital LLC (TRC) |
1,988 |
14,000 |
0.02% |
|
|
| 34 |
BLACKROCK ADVISORS LLC |
1,565 |
11,000 |
0.02% |
|
|
| 35 |
STRS OHIO |
1,500 |
10,000 |
0.02% |
|
|
| 36 |
WELLS FARGO & COMPANY/MN |
1,053 |
8,000 |
0.01% |
|
|
| 37 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
984 |
7,000 |
0.01% |
|
|
| 38 |
MSI Financial Services Inc |
700 |
5,000 |
0.01% |
|
|
| 39 |
Plante Moran Financial Advisors, LLC |
500 |
4,000 |
0.01% |
|
|
| 40 |
BANK OF MONTREAL /CAN/ |
178 |
1,000 |
0.00% |
|
|
| 41 |
BlackRock Finance, Inc. |
113 |
1,000 |
0.00% |
|
|
| 42 |
BNP PARIBAS FINANCIAL MARKETS |
76 |
549 |
0.00% |
|
|
