| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,844,546 | 173,233,000 | 42.22% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 959,010 | 27,816,000 | 6.78% | ||
| 3 | Flagship Ventures 2007 General Partner LLC | 599,297 | 17,763,000 | 4.33% | ||
| 4 | FEDERATED HERMES, INC. | 572,000 | 16,954,000 | 4.13% | ||
| 5 | WADDELL & REED FINANCIAL INC | 484,367 | 14,356,000 | 3.50% | ||
| 6 | VANGUARD GROUP INC | 480,165 | 14,232,000 | 3.47% | ||
| 7 | TimesSquare Capital Management, LLC | 445,000 | 13,190,000 | 3.21% | ||
| 8 | JENNISON ASSOCIATES LLC | 391,700 | 11,610,000 | 2.83% | ||
| 9 | BLACKROCK ADVISORS LLC | 338,428 | 10,031,000 | 2.44% | ||
| 10 | Capital World Investors | 287,500 | 8,522,000 | 2.08% | ||
| 11 | Cormorant Asset Management, LP | 250,000 | 7,410,000 | 1.81% | ||
| 12 | RA CAPITAL MANAGEMENT, L.P. | 246,645 | 7,311,000 | 1.78% | ||
| 13 | ORBIMED ADVISORS LLC | 246,645 | 7,311,000 | 1.78% | ||
| 14 | LORD, ABBETT & CO. LLC | 234,730 | 6,958,000 | 1.70% | ||
| 15 | BlackRock Fund Advisors | 204,769 | 6,069,000 | 1.48% | ||
| 16 | BRIDGER MANAGEMENT, LLC | 201,447 | 5,971,000 | 1.46% | ||
| 17 | Artal Group S.A. | 200,000 | 5,928,000 | 1.44% | ||
| 18 | BlackRock Group LTD | 192,800 | 5,715,000 | 1.39% | ||
| 19 | Rock Springs Capital Management LP | 180,000 | 5,335,000 | 1.30% | ||
| 20 | BlackRock Institutional Trust Company, N.A. | 158,859 | 4,709,000 | 1.15% | ||
| 21 | BAKER BROS. ADVISORS LP | 125,000 | 3,705,000 | 0.90% | ||
| 22 | OXFORD ASSET MANAGEMENT LLP | 121,800 | 3,610,000 | 0.88% | ||
| 23 | EVENTIDE ASSET MANAGEMENT, LLC | 107,530 | 3,187,000 | 0.78% | ||
| 24 | MILLENNIUM MANAGEMENT LLC | 103,253 | 3,060,000 | 0.75% | ||
| 25 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 101,008 | 2,994,000 | 0.73% | ||
| 26 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 95,445 | 2,829,000 | 0.69% | ||
| 27 | STATE STREET CORP | 93,511 | 2,774,000 | 0.68% | ||
| 28 | JPMORGAN CHASE & CO | 68,500 | 2,030,000 | 0.49% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 66,582 | 1,973,000 | 0.48% | ||
| 30 | SABBY MANAGEMENT, LLC | 64,775 | 1,920,000 | 0.47% | ||
| 31 | BlackRock Finance, Inc. | 55,100 | 1,633,000 | 0.40% | ||
| 32 | BlackRock Investment Management, LLC | 48,536 | 1,439,000 | 0.35% | ||
| 33 | GOLDMAN SACHS GROUP INC | 42,500 | 1,260,000 | 0.31% | Call | |
| 34 | CREDIT SUISSE AG/ | 29,178 | 865,000 | 0.21% | ||
| 35 | NORTHERN TRUST CORP | 28,739 | 852,000 | 0.21% | ||
| 36 | Alyeska Investment Group, L.P. | 25,954 | 769,000 | 0.19% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 25,459 | 755,000 | 0.18% | ||
| 38 | Bank of New York Mellon Corp | 20,129 | 597,000 | 0.15% | ||
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 15,610 | 463,000 | 0.11% | ||
| 40 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,600 | 462,000 | 0.11% | ||
| 41 | TD ASSET MANAGEMENT INC | 15,200 | 451,000 | 0.11% | ||
| 42 | GOLDMAN SACHS GROUP INC | 12,029 | 357,000 | 0.09% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 10,900 | 323,000 | 0.08% | Call | |
| 44 | RENAISSANCE TECHNOLOGIES LLC | 10,900 | 323,000 | 0.08% | ||
| 45 | MORGAN STANLEY | 10,377 | 307,000 | 0.07% | ||
| 46 | TEACHERS ADVISORS, LLC | 8,666 | 257,000 | 0.06% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 7,096 | 210,000 | 0.05% | ||
| 48 | CITIGROUP INC | 3,716 | 110,000 | 0.03% | ||
| 49 | BANK OF AMERICA CORP /DE/ | 3,554 | 105,000 | 0.03% | ||
| 50 | STRS OHIO | 2,800 | 82,000 | 0.02% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
