| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,238,465 | 217,396,000 | 46.11% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 961,076 | 39,032,000 | 8.28% | ||
| 3 | BLACKROCK ADVISORS LLC | 648,060 | 26,895,000 | 5.70% | ||
| 4 | Flagship Ventures 2007 General Partner LLC | 599,297 | 24,871,000 | 5.28% | ||
| 5 | TimesSquare Capital Management, LLC | 410,100 | 17,019,000 | 3.61% | ||
| 6 | JENNISON ASSOCIATES LLC | 390,000 | 16,185,000 | 3.43% | ||
| 7 | Capital World Investors | 375,000 | 15,563,000 | 3.30% | ||
| 8 | WADDELL & REED FINANCIAL INC | 301,290 | 12,503,000 | 2.65% | ||
| 9 | ORBIMED ADVISORS LLC | 246,645 | 10,236,000 | 2.17% | ||
| 10 | RA CAPITAL MANAGEMENT, L.P. | 246,645 | 10,236,000 | 2.17% | ||
| 11 | Rock Springs Capital Management LP | 207,215 | 8,599,000 | 1.82% | ||
| 12 | CITADEL ADVISORS LLC | 193,226 | 8,019,000 | 1.70% | ||
| 13 | BlackRock Group LTD | 192,800 | 8,001,000 | 1.70% | ||
| 14 | Artal Group S.A. | 160,057 | 6,642,000 | 1.41% | ||
| 15 | LORD, ABBETT & CO. LLC | 160,000 | 6,640,000 | 1.41% | ||
| 16 | BAKER BROS. ADVISORS LP | 125,000 | 5,188,000 | 1.10% | ||
| 17 | OXFORD ASSET MANAGEMENT LLP | 121,800 | 5,055,000 | 1.07% | ||
| 18 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 101,063 | 4,194,114 | 0.89% | ||
| 19 | MILLENNIUM MANAGEMENT LLC | 82,931 | 3,442,000 | 0.73% | ||
| 20 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 68,200 | 2,830,000 | 0.60% | ||
| 21 | JANUS HENDERSON INVESTORS US LLC | 62,073 | 2,576,000 | 0.55% | ||
| 22 | BlackRock Finance, Inc. | 55,100 | 2,287,000 | 0.49% | ||
| 23 | Cormorant Asset Management, LP | 50,000 | 2,075,000 | 0.44% | ||
| 24 | PERCEPTIVE ADVISORS LLC | 50,000 | 2,075,000 | 0.44% | ||
| 25 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 46,500 | 1,930,000 | 0.41% | ||
| 26 | EcoR1 Capital, LLC | 40,000 | 1,660,000 | 0.35% | ||
| 27 | Laurion Capital Management LP | 31,000 | 1,287,000 | 0.27% | ||
| 28 | Alyeska Investment Group, L.P. | 30,000 | 1,245,000 | 0.26% | ||
| 29 | JPMORGAN CHASE & CO | 24,800 | 1,030,000 | 0.22% | ||
| 30 | BlackRock Investment Management, LLC | 20,300 | 842,000 | 0.18% | ||
| 31 | VANGUARD GROUP INC | 20,000 | 830,000 | 0.18% | ||
| 32 | NORGES BANK | 20,000 | 830,000 | 0.18% | ||
| 33 | DEUTSCHE BANK AG\ | 19,474 | 808,000 | 0.17% | ||
| 34 | TUDOR INVESTMENT CORP ET AL | 15,000 | 623,000 | 0.13% | ||
| 35 | TD ASSET MANAGEMENT INC | 14,600 | 606,000 | 0.13% | ||
| 36 | Achievement Holdings L.P. | 13,000 | 540,000 | 0.11% | ||
| 37 | ArrowMark Colorado Holdings LLC | 10,000 | 415,000 | 0.09% | ||
| 38 | OMERS ADMINISTRATION Corp | 9,900 | 411,000 | 0.09% | ||
| 39 | Schonfeld Group Holdings LLC | 7,500 | 311,000 | 0.07% | ||
| 40 | Geduld E E | 5,000 | 208,000 | 0.04% | ||
| 41 | PLATINUM INVESTMENT MANAGEMENT LTD | 5,000 | 207,000 | 0.04% | ||
| 42 | MORGAN STANLEY | 2,500 | 104,000 | 0.02% | ||
| 43 | MAZAMA CAPITAL MANAGEMENT INC | 578 | 24,000 | 0.01% | ||
| 44 | INTEGRATED WEALTH MANAGEMENT | 300 | 12,000 | 0.00% | ||
| 45 | Chicago Partners Investment Group LLC | 100 | 4,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
