| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ROYAL BANK OF CANADA | 2,586 | 6,000 | 0.01% | ||
| 2 | UBS Group AG | 4,067 | 9,000 | 0.02% | ||
| 3 | BANK OF AMERICA CORP /DE/ | 10,000 | 23,000 | 0.06% | ||
| 4 | NOMURA HOLDINGS INC | 11,000 | 25,000 | 0.06% | ||
| 5 | GEODE CAPITAL MANAGEMENT, LLC | 12,868 | 29,000 | 0.07% | ||
| 6 | Virtu KCG Holdings LLC | 14,639 | 33,000 | 0.08% | ||
| 7 | OPPENHEIMER & CO INC | 15,000 | 34,000 | 0.08% | ||
| 8 | HighTower Advisors, LLC | 15,000 | 34,000 | 0.08% | ||
| 9 | TFS CAPITAL LLC | 23,569 | 54,000 | 0.13% | ||
| 10 | Spark Investment Management LLC | 30,200 | 69,000 | 0.17% | ||
| 11 | EMERALD ADVISERS, LLC | 56,178 | 129,000 | 0.32% | ||
| 12 | SABBY MANAGEMENT, LLC | 75,208 | 172,000 | 0.42% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 159,352 | 365,000 | 0.90% | ||
| 14 | SPHERA FUNDS MANAGEMENT LTD. | 810,000 | 1,855,000 | 4.58% | ||
| 15 | Omega Fund Management, LLC | 2,483,949 | 5,688,000 | 14.05% | ||
| 16 | Lombard Odier Asset Management (USA) Corp | 2,848,804 | 6,524,000 | 16.11% | ||
| 17 | Tekla Capital Management LLC | 3,848,191 | 8,812,000 | 21.77% | ||
| 18 | ORBIMED ADVISORS LLC | 7,259,620 | 16,625,000 | 41.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
