| 1 |
ORBIMED ADVISORS LLC |
7,259,620 |
11,688,000 |
36.83% |
|
|
| 2 |
Tekla Capital Management LLC |
3,848,191 |
6,196,000 |
19.52% |
|
|
| 3 |
Lombard Odier Asset Management (USA) Corp |
3,166,915 |
5,099,000 |
16.07% |
|
|
| 4 |
Omega Fund Management, LLC |
2,262,832 |
3,643,000 |
11.48% |
|
|
| 5 |
SABBY MANAGEMENT, LLC |
1,615,992 |
2,602,000 |
8.20% |
|
|
| 6 |
SPHERA FUNDS MANAGEMENT LTD. |
810,000 |
1,304,000 |
4.11% |
|
|
| 7 |
BVF INC/IL |
241,352 |
389,000 |
1.23% |
|
|
| 8 |
DAFNA Capital Management LLC |
223,325 |
360,000 |
1.13% |
|
|
| 9 |
Frontier Wealth Management LLC |
85,000 |
137,000 |
0.43% |
|
|
| 10 |
BlackRock Fund Advisors |
70,132 |
113,000 |
0.36% |
|
|
| 11 |
BANK OF AMERICA CORP /DE/ |
15,000 |
24,000 |
0.08% |
|
|
| 12 |
OPPENHEIMER & CO INC |
15,000 |
24,000 |
0.08% |
|
|
| 13 |
MILLENNIUM MANAGEMENT LLC |
13,097 |
21,000 |
0.07% |
|
|
| 14 |
Virtu KCG Holdings LLC |
11,750 |
20,000 |
0.06% |
|
|
| 15 |
GEODE CAPITAL MANAGEMENT, LLC |
12,868 |
20,000 |
0.06% |
|
|
| 16 |
BlackRock Institutional Trust Company, N.A. |
11,880 |
19,000 |
0.06% |
|
|
| 17 |
TFS CAPITAL LLC |
10,416 |
17,000 |
0.05% |
|
|
| 18 |
LEBENTHAL ASSET MANAGEMENT, LLC |
10,000 |
16,000 |
0.05% |
|
|
| 19 |
Lebenthal Holdings,LLC |
10,000 |
16,000 |
0.05% |
|
|
| 20 |
BlackRock Investment Management, LLC |
5,174 |
8,000 |
0.03% |
|
|
| 21 |
Creative Planning |
5,000 |
8,000 |
0.03% |
|
|
| 22 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
2,635 |
4,000 |
0.01% |
|
|
| 23 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
2,400 |
4,000 |
0.01% |
|
|
| 24 |
Walleye Trading LLC |
1,800 |
3,000 |
0.01% |
|
|
| 25 |
WOLVERINE TRADING LP /BD |
1,180 |
1,947 |
0.01% |
|
|
| 26 |
Tower Research Capital LLC (TRC) |
461 |
1,000 |
0.00% |
|
|
| 27 |
MORGAN STANLEY |
100 |
0 |
0.00% |
|
|
